4.7 Article

Aflatoxin B1 impairs porcine oocyte quality via disturbing intracellular membrane system and ATP production

Related references

Note: Only part of the references are listed.
Article Developmental Biology

Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis

Meng-Meng Shan et al.

Summary: The study reveals an important role of the motor protein KIFC1 in mouse oocyte meiosis, where it is involved in spindle migration and actin dynamics. Depletion of KIFC1 leads to abnormal meiotic division, disrupted chromosome alignment, and disturbed endoplasmic reticulum distribution.

DEVELOPMENT (2022)

Article Reproductive Biology

Zearalenone exposure impairs organelle function during porcine oocyte meiotic maturation

Yue Wang et al.

Summary: The study showed that ZEN exposure disrupted organelle function in porcine oocyte meiotic maturation, affecting mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosome.

THERIOGENOLOGY (2022)

Article Pharmacology & Pharmacy

Nivalenol affects spindle formation and organelle functions during mouse oocyte maturation

Yue Wang et al.

Summary: Oocyte maturation is crucial for successful fertilization and embryo development. However, exposure to the mycotoxin NIV can disrupt this process by altering gene expression related to spindle formation and organelle function in mouse oocytes. Additionally, NIV exposure affects mitochondria, Golgi apparatus, and endoplasmic reticulum in oocytes. These findings highlight the toxic effects of NIV on mouse oocyte quality.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2022)

Article Cell Biology

Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome

Jianping Cao et al.

Summary: In this study, it was found that miR-143-3p and miR-155-5p antagonistically regulate glycolytic-mediated follicular dysplasia of granulosa cells (GCs) in polycystic ovary syndrome (PCOS), and HK2 is the mediator of this regulation.

CELL COMMUNICATION AND SIGNALING (2022)

Article Biochemistry & Molecular Biology

Dendrobium nobile Lindl polysaccharides improve testicular spermatogenic function in streptozotocin-induced diabetic rats

Xiaocan Lei et al.

Summary: Diabetes can lead to testicular injury and impaired reproductive function, but DNLP can protect the testis from damage by promoting proliferation, inhibiting cell apoptosis, and upregulating SIRT1 expression.

MOLECULAR REPRODUCTION AND DEVELOPMENT (2022)

Article Reproductive Biology

High-dose zearalenone exposure disturbs G2/M transition during mouse oocyte maturation

Yi-Ming Ji et al.

Summary: This study found that high dose zearalenone exposure disturbed oocyte meiosis resumption, leading to G2/M arrest, and affected the function of organelles and DNA damage repair, further activating DNA damage checkpoints.

REPRODUCTIVE TOXICOLOGY (2022)

Article Cell Biology

Nivalenol affects Cyclin B1 level and activates SAC for cell cycle progression in mouse oocyte meiosis

Ping-Shuang Lu et al.

Summary: This study demonstrates that exposure to NIV affects the cell cycle progression in mouse oocyte meiosis by disrupting Cyclin B1 expression and microtubule stability.

CELL PROLIFERATION (2022)

Review Biochemistry & Molecular Biology

Mitofusins: from mitochondria to fertility

Shanjiang Zhao et al.

Summary: The role of mitochondrial fusion regulators is essential for germ cell formation, embryonic development, and the occurrence of reproductive diseases.

CELLULAR AND MOLECULAR LIFE SCIENCES (2022)

Article Agriculture, Dairy & Animal Science

Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs

Chunhua Xing et al.

Summary: Exposure to glyphosate disrupts porcine oocyte maturation by affecting gene expression and organelle functions, such as mitochondrial distribution, ER stress, lysosome function, Golgi apparatus distribution, and ribosome function.

JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY (2022)

Review Food Science & Technology

Progress on the detoxification of aflatoxin B1 using natural anti-oxidants

Xiaoxuan Wang et al.

Summary: This review provides an overview of the latest research progress on the use of natural antioxidants as antidotes to aflatoxin poisoning, including their detoxification mechanisms and application prospects.

FOOD AND CHEMICAL TOXICOLOGY (2022)

Review Obstetrics & Gynecology

Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence

Dulama Richani et al.

Summary: Metabolism is crucial for oocyte quality, with glucose being essential for COC maturation and energy production. Mitochondria are the main ATP source in oocytes, while cumulus cells play a vital role in maintaining ATP levels. New insights in oocyte lipid metabolism and innovative strategies in IVM have shown positive effects on oocyte competence.

HUMAN REPRODUCTION UPDATE (2021)

Review Biochemistry & Molecular Biology

The lysosome as an imperative regulator of autophagy and cell death

Kewal Kumar Mahapatra et al.

Summary: Lysosomes are crucial organelles responsible for degrading cellular cargo and maintaining cellular homeostasis, playing a critical role in the connection between autophagy and endocytosis. Damage to the lysosomal membrane can lead to selective lysosomal degradation pathway and trigger lysophagy in severe cases.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Article Environmental Sciences

Fumonisin B1 exposure deteriorates oocyte quality by inducing organelle dysfunction and DNA damage in mice

Yue Wang et al.

Summary: This study found that exposure to FB1 affects the quality of mouse oocytes mainly by disrupting spindle structure, leading to dysfunction of mitochondria, lysosomes, and endoplasmic reticulum, and inducing oxidative stress, apoptosis, autophagy, and DNA damage in oocytes.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY (2021)

Article Materials Science, Multidisciplinary

Loss of Arf Guanine Nucleotide Exchange Factor GBF1 Activity Disturbs Organelle Dynamics in Mouse Oocytes

Yuan-Jing Zou et al.

Summary: This study demonstrates that GBF1 is stably expressed in mouse oocytes and plays a role in regulating organelle dynamics. Inhibiting GBF1 activity results in aberrant accumulation of the Golgi apparatus, condensation of GM130, abnormal ER distribution, ER stress, and altered mitochondrial functions.

MICROSCOPY AND MICROANALYSIS (2021)

Review Obstetrics & Gynecology

Mitochondria: their role in spermatozoa and in male infertility

Magalie Boguenet et al.

Summary: Mitochondria in sperm play essential roles in energy production, redox equilibrium, calcium regulation, and apoptotic pathways, which are crucial for sperm motility, capacitation, acrosome reaction, and gametic fusion. Alterations in mitochondrial functions can lead to decline in sperm quality and fertility, while the relationship between mitochondrial genome and sperm quality is complex and heterogeneous. Understanding the role of mitochondria in male infertility is of great importance in the context of declining sperm quality.

HUMAN REPRODUCTION UPDATE (2021)

Article Reproductive Biology

Exposure to nivalenol declines mouse oocyte quality via inducing oxidative stress-related apoptosis and DNA damage

Yue Wang et al.

Summary: The study revealed that exposure to NIV causes meiotic arrest and failure of polar body extrusion in mouse oocytes, possibly exerting wide toxicity on oocyte maturation through altering gene expressions, leading to oxidative stress and DNA damage. Treatment with melatonin significantly ameliorated the defects caused by NIV exposure.

BIOLOGY OF REPRODUCTION (2021)

Article Cell Biology

RAB14 GTPase is essential for actin-based asymmetric division during mouse oocyte maturation

Yuan-Jing Zou et al.

Summary: Our study investigated the roles of RAB14 during oocyte meiotic maturation, showing that depletion of RAB14 caused large polar bodies and defects in spindle migration. The regulation on actin-based spindle migration and Golgi apparatus distribution by RAB14 during mouse oocyte meiotic maturation was suggested by our results.

CELL PROLIFERATION (2021)

Article Obstetrics & Gynecology

The multiple roles of RAB GTPases in female and male meiosis

Meng-Meng Shan et al.

Summary: RAB GTPases play critical roles in female and male meiosis, participating in various intracellular processes. They are essential for the normal growth of offspring and successful fertilization.

HUMAN REPRODUCTION UPDATE (2021)

Review Toxicology

Pesticides induced oxidative stress and female infertility: a review

Jitender Kumar Bhardwaj et al.

TOXIN REVIEWS (2020)

Article Developmental Biology

Effect of aflatoxin B1 on bovine spermatozoa's proteome and embryo's transcriptome

Alisa Komsky-Elbaz et al.

REPRODUCTION (2020)

Article Developmental Biology

Impact of endoplasmic reticulum stress on oocyte aging mechanisms

Isao Takehara et al.

MOLECULAR HUMAN REPRODUCTION (2020)

Review Reproductive Biology

Actin cytoskeleton dynamics in mammalian oocyte meiosis

Xing Duan et al.

BIOLOGY OF REPRODUCTION (2019)

Review Food Science & Technology

Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods

Blake R. Rushing et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Review Food Science & Technology

Microbiological Safety of Dried Spices

Joshua B. Gurtler et al.

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 10 (2019)

Review Cell Biology

Effects of obesity and diabetes on the epigenetic modification of mammalian gametes

Xiang-Hong Ou et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Pharmacology & Pharmacy

Aflatoxin B1 impairs sperm quality and fertilization competence

A. Komsky-Elbaz et al.

TOXICOLOGY (2018)

Article Genetics & Heredity

Aflatoxin B1 is toxic to porcine oocyte maturation

Jun Liu et al.

MUTAGENESIS (2015)

Article Biochemistry & Molecular Biology

RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis

CY Jang et al.

FEBS LETTERS (2004)