4.7 Article

CircPTEN suppresses human clear cell renal carcinoma progression and resistance to mTOR inhibitors by targeting epigenetic modification

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

PTEN loss confers sensitivity to rapalogs in clear cell renal cell carcinoma

Xiao-lian Liu et al.

Summary: PTEN loss correlates with hypersensitivity to rapalogs in ccRCC cells and could be a marker for rapalog therapy selection in ccRCC patients.

ACTA PHARMACOLOGICA SINICA (2022)

Article Biochemistry & Molecular Biology

OTUD1 stabilizes PTEN to inhibit the PI3K/AKT and TNF-alpha/NF-kappaB signaling pathways and sensitize ccRCC to TKIs

Wentao Liu et al.

Summary: This study investigates the clinicopathological role of the OTUD family in ccRCC and identifies that the OTUD1-PTEN axis suppresses tumor growth and regulates the resistance of renal cancer to TKIs.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2022)

Review Oncology

The emerging roles of circRNAs in cancer and oncology

Lasse S. Kristensen et al.

Summary: Circular RNAs (circRNAs) are a novel class of primarily non-coding RNAs with increasingly recognized roles in cancer development and progression through diverse mechanisms of action. In this review, the authors summarize the current understanding of circRNA biogenesis, regulation, physiological functions and pathophysiological roles in cancer. They also discuss the clinical potential of circRNAs as biomarkers, therapeutic agents and drug targets in oncology, as well as the research controversies, technical issues, and biological knowledge gaps that need to be addressed.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

Article Biochemistry & Molecular Biology

Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma

Xin Ge et al.

Summary: This study reveals that fumarate can accumulate in cells lacking fumarate hydratase and activate PI3K/AKT signaling by inhibiting PTEN. Fumarate directly modifies PTEN and impairs its inhibitory effect on the PI3K/AKT pathway. Clinical analysis shows a positive correlation between PTEN modification levels and AKT activation in PRCC2.

MOLECULAR CELL (2022)

Review Pharmacology & Pharmacy

N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells

Zhihua Liu et al.

Summary: This study investigated the role of circQSOX1 in CRC tumorigenesis and in regulating Treg cell-mediated CRC immune escape. The results showed that high circQSOX1 expression was associated with tumor development and poor clinical outcomes in CRC patients. Additionally, circQSOX1 promoted CRC development by regulating the miR-326/miR-330-5p/PGAM1 axis, regulated glycolysis, promoted immune escape of CRC cells, and inhibited the response to anti-CTLA-4 therapy in patients.

DRUG RESISTANCE UPDATES (2022)

Review Urology & Nephrology

Epidemiology of Renal Cell Carcinoma: 2022 Update

Laura Bukavina et al.

Summary: The incidence and mortality rates of kidney cancer vary significantly globally, with variations across time, geography, and sex. Hypertension, obesity, and smoking are the most well-established risk factors. Recent advances in genetic characterization have improved our understanding of the mutations that predispose individuals to kidney cancer.

EUROPEAN UROLOGY (2022)

Article Oncology

Translation of noncoding RNAs and cancer

Bo Zhou et al.

Summary: This article summarizes the importance of noncoding RNAs (ncRNAs) and their encoded peptides/proteins in cancer research, introduces the methods, tools, and databases for identifying and validating these peptides/proteins, and discusses the future application prospects and challenges.

CANCER LETTERS (2021)

Article Gastroenterology & Hepatology

RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target

Huarong Chen et al.

Summary: The study revealed that the m(6)A regulatory enzyme METTL3 is upregulated in colorectal cancer (CRC) and predicts poor survival in patients. Inhibition of METTL3 suppresses tumorigenesis in CRC cells and organoids. METTL3 promotes CRC development by activating the m(6)A-GLUT1-mTORC1 axis.

GASTROENTEROLOGY (2021)

Article Oncology

CircRNA in cancer: Fundamental mechanism and clinical potential

Liang Chen et al.

Summary: Circular RNAs play crucial roles in tumorigenesis and tumor development by promoting or suppressing cancers through different molecular mechanisms. With advancements in nucleic acid-based therapeutic tools, circRNAs could be explored as targetable molecules in future cancer treatments.

CANCER LETTERS (2021)

Article Cell Biology

Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation

Haiping Song et al.

Summary: The study showed that long noncoding RNA HOTAIR plays a significant role in the development of chronic myelocytic leukemia (CML) by interacting with DNA methyltransferase 1 (DNMT1) to accelerate the methylation of the PTEN gene promoter. This interaction may influence disease progression.

CELL DEATH & DISEASE (2021)

Review Oncology

N6-methyladenosine methyltransferases: functions, regulation, and clinical potential

Wei Huang et al.

Summary: This review summarizes the role of N6-methyladenosine in the transcriptome and discusses the function of m6A methyltransferases in regulating cancer biology. The article highlights the use of m6A methyltransferases in mediating therapy resistance and discusses the clinical potential of targeted strategies.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Oncology

N6-Methyladenosine-Related RNA Signature Predicting the Prognosis of Ovarian Cancer

Jiao Jiao et al.

Summary: N6-Methyladenosine (m6A) RNA methylation plays a crucial role in mRNA modification and has been linked to cancer diagnosis and treatment. This study identified a 12-gene signature panel related to m6A that can serve as an independent prognostic indicator for ovarian cancer patients. The high risk score from this panel indicates poor survival outcomes.

RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY (2021)

Article Multidisciplinary Sciences

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer

Yizhe Sun et al.

Summary: PTEN is frequently mutated in human cancers and PTEN alpha, an isoform of PTEN, remains active in cancer bearing stop-gained PTEN mutations. Through counteraction of CD8(+) T cell-mediated cytotoxicity, PTEN alpha promotes T cell dysfunction and accelerates immune-resistant cancer progression. This suggests that PTEN alpha may be a potential target in antitumor immunotherapy.

NATURE COMMUNICATIONS (2021)

Article Medicine, Research & Experimental

Alcohol promotes renal fibrosis by activating Nox2/4-mediated DNA methylation of Smad7

Qin Yang et al.

CLINICAL SCIENCE (2020)

Review Biochemistry & Molecular Biology

Emerging role of tumor-related functional peptides encoded by lncRNA and circRNA

Pan Wu et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

The potential role of RNA N6-methyladenosine in Cancer progression

Tianyi Wang et al.

MOLECULAR CANCER (2020)

Review Oncology

Roles of METTL3 in cancer: mechanisms and therapeutic targeting

Chengwu Zeng et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Biochemistry & Molecular Biology

CircRNA inhibits DNA damage repair by interacting with host gene

Xiaolong Xu et al.

MOLECULAR CANCER (2020)

Review Biochemistry & Molecular Biology

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou et al.

MOLECULAR CANCER (2020)

Review Urology & Nephrology

Epidemiology of Renal Cell Carcinoma

Umberto Capitanio et al.

EUROPEAN UROLOGY (2019)

Review Oncology

Mechanisms of PTEN loss in cancer: It's all about diversity

Virginia Alvarez-Garcia et al.

SEMINARS IN CANCER BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Functions of N6-methyladenosine and its role in cancer

Liuer He et al.

MOLECULAR CANCER (2019)

Review Genetics & Heredity

The DNA methyltransferase family: a versatile toolkit for epigenetic regulation

Frank Lyko

NATURE REVIEWS GENETICS (2018)

Article Biotechnology & Applied Microbiology

A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1

Naifei Chen et al.

GENOME BIOLOGY (2018)

Editorial Material Urology & Nephrology

Setting Research Priorities for Kidney Cancer

Jennifer M. Jones et al.

EUROPEAN UROLOGY (2017)

Review Medicine, Research & Experimental

Prostate cancer, PI3K, PTEN and prognosis

Helen M. Wise et al.

CLINICAL SCIENCE (2017)

Article Biochemistry & Molecular Biology

CircInteractome: A web tool for exploring circular RNAs and their interacting proteins and microRNAs

Dawood B. Dudekulay et al.

RNA BIOLOGY (2016)

Review Biochemistry & Molecular Biology

The Warburg Effect: How Does it Benefit Cancer Cells?

Maria V. Liberti et al.

TRENDS IN BIOCHEMICAL SCIENCES (2016)

Review Biochemistry & Molecular Biology

Epigenetic regulation in human melanoma: past and future

Debina Sarkar et al.

EPIGENETICS (2015)

Review Urology & Nephrology

International Variations and Trends in Renal Cell Carcinoma Incidence and Mortality

Ariana Znaor et al.

EUROPEAN UROLOGY (2015)

Article Biotechnology & Applied Microbiology

Prognostic Significance of mTOR and PTEN in Patients with Esophageal Squamous Cell Carcinoma

Jianjun Lu et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Review Biochemistry & Molecular Biology

PTEN

Carolyn A. Worby et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)

Review Medicine, General & Internal

Renal cell carcinoma

Eric Jonasch et al.

BMJ-BRITISH MEDICAL JOURNAL (2014)

Article Biochemistry & Molecular Biology

Circular RNAs are abundant, conserved, and associated with ALU repeats

William R. Jeck et al.

Article Gastroenterology & Hepatology

Epigenetic Regulation of Cancer Stem Cell Marker CD133 by Transforming Growth Factor-β

Hanning You et al.

HEPATOLOGY (2010)