Noncoding RNA as an influential epigenetic modulator with promising roles in cancer therapeutics

The epigenetic landscape has an important role in cellular homeostasis and its deregulation leads to cancer. Noncoding (nc)RNA networks function as major regulators of cellular epigenetic hallmarks via regulation of vital processes, such as histone modification and DNA methylation. They are integral intracellular components affecting multiple oncogenic pathways. Thus, it is important to elucidate the effects of ncRNA networks on epigenetic programming that lead to the initiation and progression of cancer. In this review, we summarize the effects of epigenetic modification influenced by ncRNA networks and crosstalk between diverse classes of ncRNA, which could aid the development of patient-specific cancer therapeutics targeting ncRNAs, thereby altering cellular epigenetics.

Automated summary

The epigenetic landscape plays a crucial role in cellular homeostasis and its disruption can lead to cancer. Noncoding RNA networks, through regulation of processes like histone modification and DNA methylation, are key intracellular components involved in controlling cellular epigenetic characteristics. Understanding the effects of these RNA networks on epigenetic programming is important for the development of targeted cancer therapeutics.