Exploring the role of gut microbiota in obesity and PCOS: Current updates and future prospects

Polycystic ovary syndrome (PCOS) is a common endocrine gynecological disorder, and the specific pathogenesis of PCOS has not been elucidated. Obesity is a current major public health problem, which is also vital to PCOS. It can exacerbate PCOS symptoms via insulin resistance and hyperandrogenemia. The treatment of PCOS patients depends on the prevailing symptoms. Lifestyle interventions and weight loss remain first-line treatments for women with PCOS. The gut microbiota, which is a current research hot spot, has a substantial influence on PCOS and is closely related to obesity. The present study aimed to elucidate the function of the gut microbiota in obesity and PCOS to provide new ideas for the treatment of PCOS.

Automated summary

Polycystic ovary syndrome (PCOS) is a common endocrine gynecological disorder with unclear pathogenesis. Obesity, a significant public health problem, plays a vital role in PCOS by worsening symptoms through insulin resistance and hyperandrogenemia. Lifestyle interventions and weight loss are the first-line treatments for PCOS, which is closely associated with the gut microbiota, a current research hotspot, and obesity. This study aims to explore the role of the gut microbiota in obesity and PCOS to offer novel insights for PCOS treatment.