Post-stroke Headache

Purpose of ReviewStroke is a major health concern and a leading cause of long-term disability. Persistent post-stroke headache (PPSH) is a common complication of stroke yet little is known about its specific characteristics or optimal management. The purpose of this review is to discuss the epidemiology, presentation, and hypothesized pathophysiology of PPSH. Acute and preventive treatment options, as well as specific concerns regarding triptans and the newer CGRP antagonists, will be discussed in detail as well.Recent FindingsThe 2018 International Classification of Headache Disorders, 3rd edition (ICHD-3) was the first headache diagnostic manual to include criteria for PPSH and defines this disorder as an acute headache that develops in close temporal relation to stroke and persists beyond 3 months. Recent literature estimates the prevalence of PPSH to be somewhere between 1 and 23% of patients post-stroke. Presentation is variable, but most often mimics tension-type headache. There are no evidence-based guidelines on the optimal treatment of PPSH.SummaryPPSH is a common but poorly understood complication of stroke. Given the significant disability burden that PPSH carries, the epidemiology and pathophysiology of PPSH, as well as the efficacy and safety of potential treatment options, warrant further investigation.

Automated summary

This review discusses the epidemiology, presentation, and pathophysiology of persistent post-stroke headache (PPSH), as well as the acute and preventive treatment options. The 2018 International Classification of Headache Disorders, 3rd edition (ICHD-3) includes criteria for diagnosing PPSH. Further investigation is needed to understand the burden of PPSH and to explore the efficacy and safety of potential treatment options.