Journal
CURRENT OPINION IN PLANT BIOLOGY
Volume 75, Issue -, Pages -Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.pbi.2023.102401
Keywords
Epigenetics; Chromatin; DNA replication; Histone modifications; Histone variants; Arabidopsis
Categories
Ask authors/readers for more resources
This study summarizes recent discoveries in plants regarding the role of H3.1 in chromatin replication, genomic stability, epigenetic inheritance, and its interaction with DNA polymerase epsilon.
The replication-dependent histone H3.1 variant, ubiquitous in multicellular eukaryotes, has been proposed to play key roles during chromatin replication due to its unique expression pattern restricted to the S phase of the cell cycle. Here, we describe recent discoveries in plants regarding molecular mechanisms and cellular pathways involving H3.1 that contribute to the maintenance of genomic and epigenomic in-formation. First, we highlight new advances concerning the contribution of the histone chaperone CAF-1 and the TSK-H3.1 DNA repair pathway in preventing genomic instability during replication. We then summarize the evidence connect-ing H3.1 to specific roles required for the mitotic inheritance of epigenetic states. Finally, we discuss the recent identification of a specific interaction between H3.1 and DNA polymerase epsilon and its functional implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available