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CD1 displays its own negative regulators

CURRENT OPINION IN IMMUNOLOGY (2023)

Related references

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Article Immunology

Staphylococcal phosphatidylglycerol antigens activate human T cells via CD1a

Gwennaelle C. Monnot et al.

Summary: CD1a presents a range of self-lipid antigens found within the skin. The study identifies CD1a-dependent T cell responses to bacterial membrane phospholipids and suggests a link between PG-based lipid-activated T cells and atopic dermatitis pathogenesis. The expansion of CD4(+) CD1a-(lysyl)PG tetramer(+) T cells in patients with atopic dermatitis supports the involvement of bacteria-associated lipids in the development of this condition.

NATURE IMMUNOLOGY (2023)

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Article Immunology

Phospholipase activity of acyloxyacyl hydrolase induces IL-22-producing CD1a-autoreactive T cells in individuals with psoriasis

Randeep Singh et al.

Summary: Psoriasis is a chronic inflammatory skin disease characterized by Th17 responses. Langerhans cells and the lipase AOAH play important roles in its pathogenesis. AOAH is involved in generating antigens that activate CD1a-restricted T cells, contributing to the inflammatory response in psoriasis.

EUROPEAN JOURNAL OF IMMUNOLOGY (2022)

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Article Multidisciplinary Sciences

CD1a promotes systemic manifestations of skin inflammation

Clare S. Hardman et al.

Summary: Inflammatory skin conditions are associated with systemic inflammation, and CD1a plays an important role in linking cutaneous and systemic inflammation. CD1a-blocking antibodies can ameliorate the exacerbated inflammation, suggesting a potential therapeutic target for controlling the systemic spread of cutaneous inflammation.

NATURE COMMUNICATIONS (2022)

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Article Multidisciplinary Sciences

Atypical sideways recognition of CD1a by autoreactive γδ T cell receptors

Marcin Wegrecki et al.

Summary: In this study, the authors reveal a novel geometrically alternate sideways mode of recognition of the antigen-presenting molecule CD1a by a gamma delta T cell receptor. The gamma delta TCR binds CD1a in a lipid-independent manner and induces clustering of TCRs and T cell signaling.

NATURE COMMUNICATIONS (2022)

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Article Immunology

Sortase A-Cleavable CD1d Identifies Sphingomyelins as Major Class of CD1d-Associated Lipids

Maren Rudolph et al.

Summary: Researchers have developed a novel system to analyze CD1d-bound lipids in mammalian cells and have gained new insights into the spectrum of CD1d-associated lipids, with important functional implications for NKT cell activation.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Medicine, Research & Experimental

Human skin is colonized b T cells that recognize CD1a independently of lipid

Rachel N. Cotton et al.

Summary: CD1a-autoreactive T cells play a role in skin disease, with the antigenic target being CD1a itself. T cells can bind various lipid ligands carried by CD1a proteins, and CD1a-specific T cells are a normal component of the human skin T cell repertoire, making CD1a tetramers a simple method to track them in tissues and clinical diseases.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Immunology

CD1a selectively captures endogenous cellular lipids that broadly block T cell response

Rachel N. Cotton et al.

Summary: The study indicates that cellular CD1a protein preferentially captures specific endogenous lipids that block its binding to T cell receptors, suggesting that this inhibitory effect may play a key role in the intrinsic autoreactivity and negative regulation of the CD1a system.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Immunology

CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules

Nicholas A. Gherardin et al.

Summary: This study identified members of the CD36 family as ligands for CD1c, CD1b, and CD1d proteins, with CD36 being responsible for non-TCR-mediated CD1c tetramer staining of blood cells. Blocking CD36 clarified the identification of CD1c-restricted T cells and enhanced the detection of CD1b- and CD1d-restricted T cells. The technique developed in this study allowed for the characterization of diverse phenotypic features, TCR repertoire, and antigen-specific subsets of CD1c-restricted T cells, facilitating further research in the biology of CD1 and human CD1-restricted T cells.

SCIENCE IMMUNOLOGY (2021)

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Article Immunology

Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products

Sarah Nicolai et al.

SCIENCE IMMUNOLOGY (2020)

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Article Immunology

CD1b Tetramers Broadly Detect T Cells That Correlate With Mycobacterial Exposure but Not Tuberculosis Disease State

Kattya Lopez et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Human γδ T cells recognize CD1b by two distinct mechanisms

Josephine F. Reijneveld et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Immunology

Control of CD1d-restricted antigen presentation and inflammation by sphingomyelin

Espen Melum et al.

NATURE IMMUNOLOGY (2019)

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A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Adam Shahine et al.

NATURE COMMUNICATIONS (2019)

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T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Kwok S. Wun et al.

NATURE IMMUNOLOGY (2018)

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Article Immunology

Elevated and cross-responsive CD1a-reactive T cells in bee and wasp venom allergic individuals

Sumithra Subramaniam et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

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Article Immunology

Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

Ka Lun Cheung et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

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Article Immunology

Molecular Analysis of Lipid-Reactive Vδ1 γδ T Cells Identified by CD1c Tetramers

Sobhan Roy et al.

JOURNAL OF IMMUNOLOGY (2016)

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Article Immunology

CD1a on Langerhans cells controls inflammatory skin disease

Ji Hyung Kim et al.

NATURE IMMUNOLOGY (2016)

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Article Cell Biology

Filaggrin inhibits generation of CD1a neolipid antigens by house dust mite-derived phospholipase

Rachael Jarrett et al.

SCIENCE TRANSLATIONAL MEDICINE (2016)

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Review Immunology

Activation of human T cells by CD1 and self-lipids

Annemieke de Jong

IMMUNOLOGICAL REVIEWS (2015)

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Bee venom processes human skin lipids for presentation by CD1a

Elvire A. Bourgeois et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2015)

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αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

Richard W. Birkinshaw et al.

NATURE IMMUNOLOGY (2015)

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Biology of CD1-and MR1-Restricted T Cells

Mariolina Salio et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

Annemieke de Jong et al.

NATURE IMMUNOLOGY (2014)

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Crystal Structure of Vδ1 T Cell Receptor in Complex with CD1d-Sulfatide Shows MHC-like Recognition of a Self-Lipid by Human γδ T Cells

Adrienne M. Luoma et al.

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A conserved human T cell population targets mycobacterial antigens presented by CD1b

Ildiko Van Rhijn et al.

NATURE IMMUNOLOGY (2013)

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CD1d-lipid antigen recognition by the γδ TCR

Adam P. Uldrich et al.

NATURE IMMUNOLOGY (2013)

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High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells

Claudia de Lalla et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2011)

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A Molecular Basis for NKT Cell Recognition of CD1d-Self-Antigen

Thierry Mallevaey et al.

IMMUNITY (2011)

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CD1b tetramers bind αβ T cell receptors to identify a mycobacterial glycolipid-reactive T cell repertoire in humans

Anne G. Kasmar et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire

Annemieke de Jong et al.

NATURE IMMUNOLOGY (2010)

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CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor

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Cellular lipidomics

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A comprehensive classification system for lipids

E Fahy et al.

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Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography

A Karadimitris et al.

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Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers

JL Matsuda et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

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In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers

K Benlagha et al.

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