Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 48, Pages 9833-9836Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02907d
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Funding
- National Institutes of Health [R01GM080295]
- Royal Institute of Technology
- China Scholarship Council
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM080295] Funding Source: NIH RePORTER
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A stimuli-responsive drug delivery system based on fluorescent, lectin-gated, mesoporous glyconanoparticles has been developed and evaluated in normal- and cancer lung epithelial cells. The gating process proved efficient, exhibiting good sealing properties in the absence of the glutathione redox trigger, avoiding premature release in normal cells. In the presence of higher levels of glutathione in cancer cells, the lectin gate was rapidly opened and the anticancer drug released.
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