4.7 Article

The copper-catalyzed synthesis of beta-trifluoromethylated acrylonitriles and trifluoromethyl-substituted 2H-azirines

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 67, Pages 13209-13212

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc05066a

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Funding

  1. National Natural Science Foundation [NSF 21472074, 21472073]
  2. Program for Changjiang Scholars, and innovative Research Team in University [IRT1138]

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The direct assembly of acrylonitriles and valuable 2H-azirines from readily available starting materials is described. This novel alkyne difunctionalization reaction proceeded under mild reaction conditions. Considering the versatile roles of 2H-azirines, this work paves the way for further modification into various heterocycles.

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