Therapeutic strategies targeting metabolic characteristics of cancer cells

Metabolic reprogramming is one of the important characteristics of cancer and is a key process leading to malignant proliferation, tumor development and treatment resistance. A variety of therapeutic drugs targeting metabolic reaction enzymes, transport receptors, and special metabolic processes have been developed. In this review, we investigate the characteristics of multiple metabolic changes in cancer cells, including glycolytic pathways, lipid metabolism, and glutamine metabolism changes, describe how these changes promote tumor development and tumor resistance, and summarize the progress and challenges of therapeutic strategies targeting various links of tumor metabolism in combination with current study data.

Automated summary

Metabolic reprogramming is a crucial process in cancer, contributing to malignant proliferation, tumor development, and treatment resistance. Various therapeutic drugs targeting metabolic reactions, transport receptors, and specific metabolic processes have been developed. This review explores the characteristics of metabolic changes in cancer cells, such as alterations in glycolytic pathways, lipid metabolism, and glutamine metabolism, and discusses how these changes promote tumor development and resistance. The progress and challenges of therapeutic strategies targeting different aspects of tumor metabolism, based on current research, are summarized.