Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2023.2227258
Keywords
Obesity; vitamin A; retinoic acid; adipocyte size; energy expenditure; >
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The rising prevalence of obesity is a serious public health threat. Vitamin A promotes adipose tissue vascular development, increases the number of adipose progenitors, and stimulates the browning process in white adipocytes as well as the thermogenic activity in brown/beige adipocytes. Hence, vitamin A is a promising anti-obesity micronutrient.
The rising prevalence of obesity is a grave public health threat. In response to excessive energy intake, adipocyte hypertrophy impairs cellular function and leads to metabolic dysfunctions while de novo adipogenesis leads to healthy adipose tissue expansion. Through burning fatty acids and glucose, the thermogenic activity of brown/beige adipocytes can effectively reduce the size of adipocytes. Recent studies show that retinoids, especially retinoic acid (RA), promote adipose vascular development which in turn increases the number of adipose progenitors surrounding the vascular vessels. RA also promotes preadipocyte commitment. In addition, RA promotes white adipocyte browning and stimulates the thermogenic activity of brown/beige adipocytes. Thus, vitamin A is a promising anti-obesity micronutrient.
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