4.7 Review

Toward the bioactive potential of myricitrin in food production: state-of-the-art green extraction and trends in biosynthesis

Related references

Note: Only part of the references are listed.
Review Food Science & Technology

Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?

Yao Chen et al.

Summary: This article reviews the potential benefits of polyphenolic compounds derived from edible parts of fruits in preventing and treating diabetes, and summarizes the signal pathways of characteristic polyphenols in reducing high blood glucose and intervening diabetic complications.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Review Food Science & Technology

Extraction of functional extracts from berries and their high quality processing: a comprehensive review

Tianlin Feng et al.

Summary: This paper presents a critical overview of novel extraction methods applicable to berries, discusses their combined use with conventional methods, introduces high quality processing technology for functional extracts, and describes the progress of their applications in the food industry.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Review Engineering, Chemical

Effect of cold plasma on different polyphenol compounds: A review

Sitesh Kumar et al.

Summary: Thermal processing is commonly used in the food industry but has negative effects. Cold plasma is a promising non-thermal method for inactivating microorganisms and affecting polyphenol compounds.

JOURNAL OF FOOD PROCESS ENGINEERING (2023)

Review Biochemistry & Molecular Biology

Recent Advances in Supercritical CO2 Extraction of Pigments, Lipids and Bioactive Compounds from Microalgae

Soultana Tzima et al.

Summary: Supercritical CO2 extraction is an environmentally friendly method that combines economic advantages. Microalgae, as a readily available biomass, can provide a wide range of valuable compounds for various industries such as food, cosmetics, pharmaceuticals, and biofuels. This study extensively examines the literature on supercritical fluid extraction (SFE) of microalgae, with a focus on the recovery of carotenoids, chlorophylls, lipids, and fatty acids, as well as the bioactivity of the extracts. The study also includes kinetic models for describing SFE processes, experimental design, biomass pretreatment methods before SFE, and comparison with other extraction techniques.

MOLECULES (2023)

Article Plant Sciences

The R2R3-MYB-SG7 transcription factor CaMYB39 orchestrates surface phenylpropanoid metabolism and pathogen resistance in chickpea

Samiksha Saxena et al.

Summary: Flavonoids play important roles in plants as pigments and defense compounds. This study investigates the transcriptional regulation of flavonoid biosynthesis by the R2R3-MYB transcription factor CaMYB39 in chickpea. Overexpression of CaMYB39 affects the phenylpropanoid pathway and leads to increased levels of isoflavonoids. CaMYB39 activates the transcription of early flavonoid biosynthetic genes, particularly FLAVONOL SYNTHASE2, explaining the preferential accumulation of kaempferol derivatives in chickpea. Additionally, CaMYB39 overexpression enhances trichome density, induces defense gene expression, and reduces symptoms of the fungal pathogen Ascochyta rabiei, providing resistance against Ascochyta blight.

NEW PHYTOLOGIST (2023)

Article Plant Sciences

RNA-Seq reveals the key pathways and genes involved in the light-regulated flavonoids biosynthesis in mango (Mangifera indica L.) peel

Minjie Qian et al.

Summary: Light is an essential environmental factor regulating flavonoids biosynthesis in mango peel. Bagging treatment inhibits the accumulation of flavonols and anthocyanins but promotes proanthocyanidins accumulation. Through RNA-seq analysis, 16 flavonoids biosynthetic genes were identified as crucial for different flavonoids compositions biosynthesis in mango under bagging treatment. MYB, bHLH, ERF, WRKY, and bZIP were the most important transcription factors involved in the light-regulated flavonoids biosynthesis in mango.

FRONTIERS IN PLANT SCIENCE (2023)

Review Pharmacology & Pharmacy

Advances in Oral Drug Delivery Systems: Challenges and Opportunities

Jie Lou et al.

Summary: The oral route is preferred for drug delivery but faces challenges due to the harsh gastrointestinal environment. Innovative approaches including nanoparticulate formulations, biomimetic drug formulations, and microfabricated devices have been explored for improved targeting and bioavailability. This review discusses anatomical, biochemical, and physiological factors influencing oral drug delivery and highlights recent advances in conventional and novel approaches. The challenges and opportunities of oral drug delivery systems are also addressed.

PHARMACEUTICS (2023)

Review Food Science & Technology

Natural Deep Eutectic Solvents (NADESs) Combined with Sustainable Extraction Techniques: A Review of the Green Chemistry Approach in Food Analysis

Ciro Cannavacciuolo et al.

Summary: Usual extraction processes for analyzing foods, supplements, and nutraceutical products involve massive amounts of organic solvents causing negative impact on the environment and human health. Natural deep eutectic solvents (NADES), a new class of green solvents, are sustainable, biodegradable, non-toxic and cost-effective, making them a valid alternative to conventional solvents. This review provides an overview of NADES, including their classification, preparation methods, physicochemical properties, toxicity, and their potential application as extractants of bioactive compounds in food analysis.

FOODS (2023)

Review Plant Sciences

Advances of non-conventional green technologies for phyto-saccharides extraction: current status and future perspectives

Jawaher AlYammahi et al.

Summary: This review focuses on the application of five advanced non-conventional green techniques in the extraction of saccharides. It introduces the principles, advantages, limitations, and operating parameters of these techniques, and discusses the recent progress and trends in the field. The review also comments on the modifications and integration aspects of extraction techniques, and highlights the challenges and future research prospects for lignocellulosic biomass extraction.

PHYTOCHEMISTRY REVIEWS (2023)

Review Food Science & Technology

Beneficial effects of phenolic compounds: native phenolic compounds vs metabolites and catabolites

Lidija Jakobek et al.

Summary: This paper reviews the current understanding of the beneficial effects of native phenolic compounds and their metabolites on the health of the digestive system, including gastrointestinal and urinary tract disorders and liver health. The studies mainly link the benefits in the gastrointestinal and urinary tract to whole foods rich in phenolics or the amount of phenolic compounds/antioxidants in food. However, the bioactivity of parent phenolic compounds in the digestive tract and their impact on gut microbiota should not be ignored. The influence of metabolites and catabolites may be more important for the liver and urinary tract.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Review Food Science & Technology

Green and sustainable extraction of lignin by deep eutectic solvent, its antioxidant activity, and applications in the food industry

Man Zhou et al.

Summary: Lignin, an amorphous biomacromolecule abundant in plants, has various bioactivities and is renewable. Deep eutectic solvent (DES) has been recognized as an environmentally friendly medium for efficiently extracting lignin. This article reviews recent advances in DES extraction of lignin, explores factors influencing lignin's antioxidant activity and its structure relationship, and discusses lignin's applications in the food industry.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2023)

Article Plant Sciences

Photoprotective role of plant secondary metabolites: Biosynthesis, photoregulation, and prospects of metabolic engineering for enhanced protection under excessive light

Maneesh Lingwan et al.

Summary: Light is essential for plants, but excessive light can be harmful. Plants have developed adaptations to protect themselves from harmful radiation, such as the production of secondary metabolites like flavonoids and carotenoids. Light regulates the accumulation of these metabolites through various molecular mechanisms. Understanding these mechanisms and using metabolic engineering can help enhance the production of beneficial metabolites and create climate-resilient plants. Optimum artificial lighting can also increase the production of these metabolites, which have nutritional and medicinal benefits.

ENVIRONMENTAL AND EXPERIMENTAL BOTANY (2023)

Review Chemistry, Applied

Pulsed electric field as a promising technology for solid foods processing: A review

Cheng Zhang et al.

Summary: This article reviews the application of PEF in solid food processing and its impact on food quality, discusses the evaluation techniques for PEF-treated tissues and characteristics of PEF treatment chambers, and explores the effects of other pre-treatments used in conjunction with PEF. The main obstacles and prospects of PEF in solid food processing are also examined.

FOOD CHEMISTRY (2023)

Article Green & Sustainable Science & Technology

Application of pressurized liquid extraction to grape by-products as a circular economy model to provide phenolic compounds enriched ingredient

Matteo Perra et al.

Summary: The aim of this study was to optimize the recovery of phenolic compounds from Cannonau grape pomaces using Pressurized Liquid Extraction (PLE). Response Surface Methodology (RSM) based on a Central Composite Design 23 model was used to perform PLE experiments. The results showed that the optimum values for phenolics extraction were 130 degrees C, 55% ethanol, and 22 min. The proposed experimental model proved to be a valuable alternative method for the extraction of bioactive compounds from wine-making by-products.

JOURNAL OF CLEANER PRODUCTION (2023)

Article Plant Sciences

Campomanesia lineatifolia Ruiz & Pavon (Myrtaceae): Isolation of major and minor compounds of phenolic-rich extract by high-speed countercurrent chromatography and anti-inflammatory evaluation

Nivea Cristina Vieira Neves et al.

Summary: The leaves of Campomanesia lineatifolia, an edible plant in the Brazilian Forest, have been traditionally used for treating gastrointestinal disorders. The phenolic-rich ethanol extract (PEE) from C. lineatifolia leaves showed significant anti-inflammatory activity. The study aimed to identify the chemical composition of PEE and evaluate its potential in treating gastrointestinal disorders.

JOURNAL OF ETHNOPHARMACOLOGY (2023)

Article Chemistry, Analytical

Ultra-high-performance liquid chromatography-Quadrupole-Exactive-Orbitrap-tandem mass spectrometry-based putative identification for Eucommiae Folium (Duzhongye) and its quality-marker candidate for pharmacopeia

Shuqin Liu et al.

Summary: This study used ultra-high-performance liquid chromatography coupled with hybrid quadrupole-orbitrap tandem mass spectrometry to identify 26 bioactive compounds in Eucommiae Folium (Duzhongye), including flavonoids, caffeoylquinic acids, alkaloids, lignans, xanthones, and steroids. The flavonoid isoquercitrin was recommended as a new pharmacopeia quality-marker candidate.

JOURNAL OF SEPARATION SCIENCE (2023)

Review Biochemistry & Molecular Biology

Supercritical Carbon Dioxide Technology for Recovering Valuable Phytochemicals from Cannabis sativa L. and Valorization of Its Biomass for Food Applications

Ana Carolina de Aguiar et al.

Summary: This review explores the potential of integrating high-pressure supercritical CO2 technology into the Cannabis sativa L. processing chain to extract phytochemical compound-rich extracts for health-promoting purposes. The study reviews the cannabis plant, cannabinoids, and endocannabinoid system to understand their therapeutic and side effects, and presents supercritical fluid extraction as an alternative method for producing cannabis bioproducts. It also examines the impact of extraction conditions on different parts of the cannabis plant and discusses the opportunities of using non-thermal supercritical CO2 processing for industrial hemp valorization.

MOLECULES (2023)

Review Biochemistry & Molecular Biology

Pressurized Liquid Extraction for the Recovery of Bioactive Compounds from Seaweeds for Food Industry Application: A Review

Ana Perez-Vazquez et al.

Summary: Seaweeds are gaining attention in the food industry due to their composition of various nutrients and bioactive compounds. Pressurized liquid extraction (PLE) is a green technique used to extract these components from seaweeds efficiently. By optimizing parameters such as solvent, temperature, pressure, extraction time, and number of cycles, PLE can extract target analytes in a short time period while using less solvent. Combining PLE with other techniques, such as PLE-SFE-CO2, is the best option for obtaining a high yield and economic feasibility. The compounds extracted from seaweeds can be incorporated into food packaging, food products, and animal feed to improve their nutritional and technological properties.

ANTIOXIDANTS (2023)

Review Food Science & Technology

Pressurized Liquid Extraction: A Powerful Tool to Implement Extraction and Purification of Food Contaminants

Laura Barp et al.

Summary: Pressurized liquid extraction (PLE) is an advanced extraction technique aimed at saving time and reducing solvent in comparison to traditional extraction processes. It is commonly used for solid and semi-solid samples, employing solvent extraction at elevated temperatures and pressures. The use of specific pressure and temperature conditions changes the physicochemical properties of the extraction solvent, allowing deeper penetration into the matrix to be extracted. By combining extraction and clean-up steps, PLE becomes a versatile and selective technique. This review focuses on recent applications of PLE in the field of food contaminants.

FOODS (2023)

Review Food Science & Technology

Polyphenol-Dietary Fiber Conjugates from Fruits and Vegetables: Nature and Biological Fate in a Food and Nutrition Perspective

Ana Fernandes et al.

Summary: In recent years, many studies have explored the relationship between polyphenol intake and the prevention of chronic diseases. Most research focuses on extractable polyphenols found in plant-derived foods, while non-extractable polyphenols, associated with dietary fibers, are often ignored. However, these non-extractable polyphenols may have longer-lasting bioactivities and are of interest in the food industry for their potential technological functionalities. Limited research has been conducted on these conjugates, and this review aims to examine their nutritional and biological effects, as well as their functional properties.

FOODS (2023)

Article Plant Sciences

Functional analysis of flavanone 3-hydroxylase (F3H) from Dendrobium officinale , which confers abiotic stress tolerance

Can Si et al.

Summary: This study characterized a key flavonoid biosynthesis gene, flavanone 3-hydroxylase (F3H), from Dendrobium officinale and found that it was involved in the biosynthesis of flavonoids. The DoF3H protein showed high homology with F3H proteins from other plant species and its mRNA levels were induced by salt and cold stresses. Heterologous expression of DoF3H in Escherichia coli conferred higher tolerance to salt and cold stresses.

HORTICULTURAL PLANT JOURNAL (2023)

Article Chemistry, Multidisciplinary

Separation of flavonoids with significant biological activity from Acacia mearnsii leaves

Cuihua Wu et al.

Summary: This study separated and purified myricitrin (W3) and myricetin-3-O-glucoside (W1) from Acacia mearnsii leaves, and evaluated their antioxidant and hypoglycemic activities. The results showed that A. mearnsii leaves can serve as a potential source for producing antioxidants and type II diabetes inhibitors.

RSC ADVANCES (2023)

Article Food Science & Technology

Separation of three flavonoid glycosides from Polygonum multiflorum Thunb. leaves using HSCCC and their antioxidant activities

Ming-yuan Cao et al.

Summary: In this study, three flavonoid glycosides were successfully separated and characterized from Polygonum multiflorum Thunb. The antioxidant activities of these compounds were evaluated and myricitrin and quercitrin were found to have strong antioxidant potential, indicating the pharmaceutical potential of P. multiflorum as natural antioxidant agents.

EUROPEAN FOOD RESEARCH AND TECHNOLOGY (2022)

Article Food Science & Technology

Perspectives on the design of microbial cell factories to produce prenylflavonoids

Daniela Gomes et al.

Summary: Prenylflavonoids are bioactive compounds with limited natural sources. Using microorganisms as cell factories is a faster and cheaper alternative for their production. Saccharomyces cerevisiae and Escherichia coli can be used as suitable chassis, but challenges remain in terms of yield and titer.

INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY (2022)

Article Plant Sciences

α-glucosidase inhibitors from Syzygium polyanthum (Wight) Walp leaves as revealed by metabolomics and in silico approaches

Mohamad Ana Syabana et al.

Summary: Metabolomics was used to identify myricitrin and EGCG as alpha-glucosidase inhibitors from Syzygium polyanthum leaves, with docking analysis confirming their inhibitory activity, justifying the traditional use of the plant as an antidiabetic herbal remedy.

JOURNAL OF ETHNOPHARMACOLOGY (2022)

Article Chemistry, Applied

Ovicidal activity of the hydroalcoholic extract of Brazilian peppertree (Schinus terebinthifolia Raddi) against Ancylostoma spp. from naturally parasitized dogs

Debora de Campos Anana et al.

Summary: The study demonstrated that the hydroalcoholic extract of Schinus terebinthifolia shows promising ovicidal activity against Ancylostoma spp., even after being stored for 36 months. LC-MS analysis identified ethyl gallate, myricitrin, and gallic acid as major compounds in the extract.

NATURAL PRODUCT RESEARCH (2022)

Review Food Science & Technology

Extraction of bioactive compounds from plant materials using combination of various novel methods: A review

Avinash Kumar Jha et al.

Summary: The first step in isolating and purifying bioactive compounds from plant material is extraction. Conventional extraction methods have been replaced by innovative technologies, which improve extraction rates, reduce impurities, preserve thermo-sensitive compounds, and are environmentally friendly. This review evaluates the efficiency of different conventional, novel, and combined novel technologies in the extraction of bioactive compounds from plant materials.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2022)

Article Environmental Sciences

Bioactivities and phenolic composition of Limonium boitardii Maire and L. cercinense Brullo & Erben (Plumbaginaceae): two Tunisian strict endemic plants

Ons Sefi et al.

Summary: This study investigated for the first time the antioxidant, anti-inflammatory, and enzyme inhibitory activities of the Tunisian endemic plants L. boitardii and L. cercinense. The results showed that L. cercinense exhibited strong antioxidant and anti-inflammatory effects, with both species showing high activity in tyrosinase and alpha-glucosidase inhibition tests, particularly L. cercinense. These two plants are valuable new natural sources for cosmetic and pharmacological applications.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH (2022)

Article Biotechnology & Applied Microbiology

High efficient production of plant flavonoids by microbial cell factories: Challenges and opportunities

Jiachen Sun et al.

Summary: Plant flavonoids are secondary metabolites with various physiological and pharmacological activities. Current production methods from plants or chemicals do not meet the requirements of green and sustainable development. Microbial synthesis of flavonoids has shown potential for large-scale production, but challenges such as metabolic flux imbalance and conflict between cell growth and production hinder commercialization of microbial cell factories. Strategies discussed in this article, combined with protein structure prediction, de novo protein design, artificial intelligence, biocatalytic retrosynthesis, and intelligent stress resistance, provide insights for efficient production of plant flavonoids and other natural products in microbial cell factories.

METABOLIC ENGINEERING (2022)

Review Plant Sciences

Intensification of supercritical fluid in the extraction of flavonoids: A comprehensive review

U. G. Vinitha et al.

Summary: Supercritical CO2 extraction, with its high compressibility and physiological compatibility, has replaced organic solvents in the extraction process. This review summarizes research on the extraction of flavonoids using supercritical fluids, including the parameters affecting the process and optimization methods.

PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY (2022)

Review Chemistry, Analytical

Green solvents and approaches recently applied for extraction of natural bioactive compounds

Beshare Hashemi et al.

Summary: The consumption of toxic organic solvents in chemical processes can lead to health and environmental issues, so the importance of green chemistry is increasing. Various sustainable solvents have been introduced and explored for the extraction of natural bioactive compounds. Common sustainable extraction techniques and chemometric approaches are also discussed.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2022)

Review Agricultural Engineering

Microbial cell factories for the production of flavonoids-barriers and opportunities

Hongbiao Li et al.

Summary: Flavonoids, natural plant products with important nutritional value, health-promoting benefits, and therapeutic potential, can be efficiently produced by microbial cell factories. This review compares microbial biosynthesis of flavonoids with the traditional plant extract approach and discusses its pharmaceutical applications. It summarizes approaches for effective biosynthesis of flavonoids from microorganisms, and discusses the challenges and prospects of microbial flavonoid biosynthesis. The barriers and strategies for industrial bio-production of flavonoids are highlighted, providing guidance for creating robust microbial cell factories for producing flavonoids and other relevant chemicals.

BIORESOURCE TECHNOLOGY (2022)

Review Food Science & Technology

Modulation of integrin receptor by polyphenols: Downstream Nrf2-Keap1/ARE and associated cross-talk mediators in cardiovascular diseases

Sajad Fakhri et al.

Summary: Integrin receptors play a role in cardiovascular diseases and modulation of the integrin pathway can trigger downstream antioxidant pathways for cardioprotection. Plant polyphenols, as safe and effective phytochemicals, have the potential to treat cardiovascular diseases.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2022)

Review Food Science & Technology

Ultrasound-Assisted Extraction and the Encapsulation of Bioactive Components for Food Applications

Nitin Mehta et al.

Summary: There is a rich potential of underutilized bioactive components in nature, and ultrasound-assisted extraction and encapsulation techniques have promising applications in the food industry to reduce costs, operational time, and energy consumption.

FOODS (2022)

Review Food Science & Technology

The emerging role of dark berry polyphenols in human health and nutrition

Jerome Higbee et al.

Summary: This review examines the chemical compositions of several dark berries and their impact on the ADME process, their implication in host health effects, and the potential of these emerging species to suggest areas for future research.

FOOD FRONTIERS (2022)

Article Biochemistry & Molecular Biology

Hyperglycemia-induced oxidative stress in isolated proximal tubules of mouse: the in vitro effects of myricitrin and its solid lipid nanoparticle

Akram Ahangarpour et al.

Summary: The study demonstrated that Myricitrin and its solid lipid nanoparticles can alleviate oxidative stress, inflammation, and apoptosis induced by hyperglycemia in kidney tubular cells. These findings suggest the potential of Myricitrin and its solid lipid nanoparticles in preventing and treating hyperglycemia-induced damage in proximal tubules.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY (2021)

Review Food Science & Technology

Recent advances in continuous extraction of bioactive ingredients from food-processing wastes by pulsed electric fields

Jun Xi et al.

Summary: PEF continuous extraction is a novel extraction technology that shows great potential in extracting active ingredients from food-processing wastes with high efficiency and low temperature. Compared to traditional methods, this technology has many remarkable potential applications in the food-processing industries.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2021)

Article Chemistry, Medicinal

Myricitrin fromCombretum lanceolatumExhibits Inhibitory Effect on DNA-Topoisomerase Type IIαand Protective Effect AgainstIn VivoDoxorubicin-Induced Mutagenicity

Renata Trentin Perdomo et al.

Summary: This study evaluated the antiproliferative potential of myricitrin obtained from Combretum lanceolatum against different cancer cell lines, showing strong inhibitory effects on HL-60 cells and weak activity on other cell lines. In addition, the results suggested that the antiproliferative activity of myricitrin is likely mediated through the inhibition of topoisomerase II alpha.

JOURNAL OF MEDICINAL FOOD (2021)

Article Chemistry, Applied

Isolation and characterization of flavonoids fromTapirira guianensisleaves with vasodilatory and myeloperoxidase-inhibitory activities

Laura L. Calassara et al.

Summary: The study focused on isolating and characterizing vasodilatory flavonoids from Tapirira guianensis leaves, with myricitrin and quercetin identified as the main contributors to vasodilatory effects and myeloperoxidase inhibition. These flavonoids appear to be responsible for the cardiovascular effects of Tapirira guianensis.

NATURAL PRODUCT RESEARCH (2021)

Article Chemistry, Medicinal

Insulin-Mimic Components in Acer truncatum Leaves: Bio-Guided Isolation, Annual Variance Profiling and Regulating Pathway Investigated by Omics

Xiao-Yue Zhang et al.

Summary: The study on Acer truncatum leaves revealed myricitrin as a key active component that can promote glucose uptake and potentially has anti-diabetic functions. Analysis of genes and metabolites in Zebrafish showed that myricitrin regulates glucose uptake by affecting toll-like receptors signaling pathways.

PHARMACEUTICALS (2021)

Article Cell Biology

Myricitrin ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor

Yang Gao et al.

Summary: The study investigated the effect of Myricitrin on cognitive deficits post-cerebral ischemic stroke in rats and found that it improved memory by modulating the expression of BDNF and Syn-I as well as histone acetylation levels.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Review Agriculture, Multidisciplinary

Review on Extraction of Phenolic Compounds from Natural Sources Using Green Deep Eutectic Solvents

Ali Ali Redha

Summary: This literature review discusses the extraction of phenolic compounds using green deep eutectic solvents, including their composition, factors affecting extraction, and extraction conditions.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2021)

Article Biotechnology & Applied Microbiology

Effects of metabolic pathway gene copy numbers on the biosynthesis of (2S)-naringenin in Saccharomyces cerevisiae

Hongbiao Li et al.

Summary: Flavonoids have notable biological activities and are widely used in various industries. This study successfully integrated multiple flavonoid pathway genes in a single-step integration method in yeast, significantly improving the production of naringenin. Optimizing the supply of donor DNA and utilizing a high titer p-coumaric acid strain as a chassis were key factors in enhancing flavonoid production.

JOURNAL OF BIOTECHNOLOGY (2021)

Article Biochemistry & Molecular Biology

Myricitrin, a Glycosyloxyflavone in Myrica esculenta Bark Ameliorates Diabetic Nephropathy via Improving Glycemic Status, Reducing Oxidative Stress, and Suppressing Inflammation

Tarun K. Dua et al.

Summary: The study demonstrated that Myricitrin has therapeutic potential in diabetic nephropathy by improving glucose uptake, alleviating toxicity induced by high glucose, attenuating oxidative stress and inflammation, and inhibiting apoptosis and fibrosis in renal cells. Additionally, in silico analysis predicted the drug-likeness of Myricitrin, suggesting it as a potential therapeutic agent for diabetic nephropathy.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L.

Iva Rukavina et al.

Summary: Natural deep eutectic solvents (NADES) composed of choline chloride, sucrose, fructose, glucose, and xylose were used to extract antioxidants from sea knotgrass in this study. The NADES extracts showed higher antioxidant activity compared to conventional solvents, with ChCl:fructose being the most efficient in the radical scavenging assay. The phenolic composition of NADES extracts was less complex but contained similar proportions of major antioxidants like flavonols and flavan-3-ols compared to conventional extracts.

MOLECULES (2021)

Article Chemistry, Medicinal

HPLC Determination of Myricitrin in Juglans nigra L. Bark

V. A. Kurkin et al.

Summary: An HPLC method was developed for quantitative determination of myricitrin in black walnut bark, with the content of the dominant flavonoid myricitrin ranging from 3.10% to 3.18% in J. nigra bark. The error of a single determination of myricitrin in the bark was +/- 5.81% with a confidence probability of 95%.

PHARMACEUTICAL CHEMISTRY JOURNAL (2021)

Article Engineering, Chemical

Recovering phenolic compounds from Eugenia calycina Cambess employing high-intensity ultrasound treatments: A comparison among its leaves, fruit pulp, and seed as promising sources of bioactive compounds

Nayara Macedo Peixoto Araujo et al.

Summary: This study aimed to evaluate the recovery of phenolic compounds from different parts of Eugenia calycina using high-intensity ultrasound. The results showed that high-power short-time treatment was more efficient in extracting phenolic compounds, with leaves containing the highest content of phenolic compounds and antioxidant activity.

SEPARATION AND PURIFICATION TECHNOLOGY (2021)

Review Immunology

Natural Polyphenols as Targeted Modulators in Colon Cancer: Molecular Mechanisms and Applications

Jing Long et al.

Summary: Natural polyphenols, valued for their anti-inflammatory and antioxidant properties, have shown to play a key role in the prevention and treatment of colon cancer by maintaining a balance between gut microbes and hosts.

FRONTIERS IN IMMUNOLOGY (2021)

Review Food Science & Technology

Conventional versus green extraction techniques - a comparative perspective

Carene Picot-Allain et al.

Summary: The revolutionary development of green technology has significantly influenced the recovery of natural compounds for the food industry, with novel extraction methods and the use of green solvents. While green extraction techniques are environmentally friendly and consider health and safety aspects, challenges such as capital investment and running costs are major barriers to their implementation.

CURRENT OPINION IN FOOD SCIENCE (2021)

Review Nutrition & Dietetics

Nutrients and Dietary Approaches in Patients with Type 2 Diabetes Mellitus and Cardiovascular Disease: A Narrative Review

Carlos Jimenez-Cortegana et al.

Summary: CVD is the leading cause of morbidity and mortality in developed countries, especially prevalent in patients with T2DM, who can benefit from lifestyle changes, including dietary modifications. Various diets and supplements have shown beneficial effects in T2DM and CVD, but further research, guidelines, and recommendations are needed for patients with both conditions.

NUTRIENTS (2021)

Review Chemistry, Multidisciplinary

Basics and properties of deep eutectic solvents: a review

Tracy El Achkar et al.

Summary: Deep eutectic solvents, emerging in green chemistry only seventeen years ago, have led to a plethora of publications covering various research areas and diverse fields of application. They are seen as promising alternatives to conventional organic solvents due to their straightforward preparation using highly accessible and natural compounds, as well as high tunability in properties. The physicochemical properties of these solvents, such as phase behavior, density, viscosity, ionic conductivity, surface tension, and polarity, can be controlled by factors like the choice of forming compounds, molar ratio, temperature, and water content.

ENVIRONMENTAL CHEMISTRY LETTERS (2021)

Article Biochemistry & Molecular Biology

Insights of Phenolic Pathway in Fruits: Transcriptional and Metabolic Profiling in Apricot (Prunus armeniaca)

Helena Gomez-Martinez et al.

Summary: This study investigated the phenolic pathway and the roles of key gene enzymes in synthesizing polyphenols in apricots. It identified key genes and enzymes that play important roles in polyphenol accumulation, providing a foundation for further research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Chemistry, Analytical

qNMR quantification of phenolic compounds in dry extract of Myrcia multiflora leaves and its antioxidant, anti-AGE, and enzymatic inhibition activities

Edinilze S. C. Oliveira et al.

Summary: The extract from Myrcia multiflora leaves contains a variety of phenolic compounds with antidiabetic, antioxidant activities, and no cytotoxicity. These compounds can be used as chemical markers in this matrix.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2021)

Review Plant Sciences

Natural Deep Eutectic Solvents (NADES): Phytochemical Extraction Performance Enhancer for Pharmaceutical and Nutraceutical Product Development

Ni Putu Ermi Hikmawanti et al.

Summary: The selection of extracting solvent is crucial for the extraction of natural products from plants. The pharmacological properties of plant extracts are related to their solubility, stability, and bioavailability. Deep eutectic solvents have the potential to improve the extraction performance of plant metabolites and can be used in pharmaceutical formulations development.

PLANTS-BASEL (2021)

Article Biochemistry & Molecular Biology

Secondary metabolites from Hypericum trichocaulon Boiss. & Heldr., growing wild in the island of crete

Artemis Daskalaki et al.

Summary: Eleven compounds were isolated from the aerial parts of Hypericum trichocaulon Boiss. & Heldr., including a previously undescribed prenylated phloroglycinol derivative and ten known compounds. The structures were established by NMR and MS analysis. Myricitrin, a specialized metabolite, was found in high amounts and serves as a marker for this species.

BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2021)

Review Medicine, Research & Experimental

Adipose-derived stem cells in ovarian cancer progression, metastasis, and chemoresistance

Wenjing Zhang et al.

Summary: Ovarian cancer, the deadliest gynecological malignancy, is influenced by the interactions between adipose-derived stem cells and cancer cells in the tumor microenvironment, leading to tumor progression and chemoresistance.

EXPERIMENTAL BIOLOGY AND MEDICINE (2021)

Article Biochemistry & Molecular Biology

Apoptotic mechanisms of myricitrin isolated from Madhuca longifolia leaves in HL-60 leukemia cells

Monaj Kumar Sarkar et al.

Summary: Myricitrin induces apoptosis in HL-60 leukemia cells by reducing mitochondrial membrane potential, increasing DNA fragmentation, inhibiting cell survival proteins, and inducing pro-apoptotic proteins.

MOLECULAR BIOLOGY REPORTS (2021)

Article Biochemistry & Molecular Biology

Antioxidant and Anticholinesterase Activities of Extracts and Phytochemicals of Syzygium antisepticum Leaves

Supachoke Mangmool et al.

Summary: Bioassay-guided separation of young leaves extracts of Syzygium antisepticum led to the isolation of various natural compounds from ethyl acetate and methanol extracts. These compounds showed strong antioxidant and anticholinesterase activities, indicating their potential as sources of antioxidants and anticholinesterase agents.

MOLECULES (2021)

Article Plant Sciences

Characterization of phenolic compounds by UHPLC-QTOF-MS/MS and functional properties of Syzygium malaccense leaves

Anaclara Prasniewski et al.

Summary: The study identified the chemical composition and nutritional value of Syzygium malaccense leaves, revealing various flavonoid derivatives and phenolic compounds, as well as demonstrating anti-inflammatory activity.

SOUTH AFRICAN JOURNAL OF BOTANY (2021)

Article Cell Biology

Tumor Necrosis Factor Alpha Signaling and Organogenesis

Kai You et al.

Summary: TNF-alpha plays various roles in organogenesis, including immune regulation, tumor inhibition, and interference with normal developmental processes. Inflammatory TNF-alpha also has significant regulatory effects on organogenesis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Chemistry, Medicinal

Antimicrobial and α-Amylase Inhibitory Activities of Constituents from Elaeocarpus floribundus

Ayorinde Victor Ogundele et al.

Summary: Elaeocarpus floribundus, traditionally used for treating diabetes, dysentery, and inflamed gums, yielded five known compounds from its leaf extract. Among them, myricitrin exhibited the highest inhibitory activity against alpha-amylase.

REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY (2021)

Review Andrology

Oxidative Stress, Diet and Prostate Cancer

Bee Ling Tan et al.

Summary: Prostate cancer, the second leading cancer in men worldwide, is influenced by reactive oxygen species (ROS) balance mediated by androgen. While conventional therapy is effective in localized prostate cancer, dietary habits rich in antioxidants can modulate oxidative stress and prostate cancer risk. Further discussion on the interactions and mechanisms of ROS-mediated oxidative stress in prostate cancer is warranted.

WORLD JOURNAL OF MENS HEALTH (2021)

Article Integrative & Complementary Medicine

Anti-influenza A virus activity of two Newtonia species and the isolated compound myricetin-3-o-rhamnoside

Katlego E. Motlhatlego et al.

Summary: The study found that the leaf extracts of Newtonia hildebrandtii and N. buchananii had significant antiviral activity against the H1N1 influenza virus. Myricitrin in the extracts was most effective in inhibiting viral attachment and entry stages. These findings support further research on these plants and compounds for controlling viral infections.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2021)

Article Andrology

Effects of Myricitrin and Solid Lipid Nanoparticle-Containing Myricitrin on Reproductive System Disorders Induced by Diabetes in Male Mouse

Ali Akbar Oroojan et al.

Summary: The study showed that myricitrin and solid lipid nanoparticles containing myricitrin can improve reproductive system issues in type 2 diabetic male mice, with a stronger effect observed at higher doses. These treatments can increase testis weight and volume, enhance antioxidant capacity, and restore hormone levels and sperm count.

WORLD JOURNAL OF MENS HEALTH (2021)

Review Food Science & Technology

Combination of emerging technologies for the extraction of bioactive compounds

Le Wen et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Review Food Science & Technology

Targeting NF-κB signaling pathway in cancer by dietary polyphenols

Haroon Khan et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

Article Biochemistry & Molecular Biology

The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis

Hongming Lv et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2020)

Article Urology & Nephrology

Myricitrin protects against cisplatin-induced kidney injury by eliminating excessive reactive oxygen species

Ruiqian Li et al.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2020)

Article Agricultural Engineering

Comparison of chemical composition of lipophilic extracts from Acacia mearnsii De Wild. wood of different ages

Gliciane Ramos Azevedo Oliveira et al.

INDUSTRIAL CROPS AND PRODUCTS (2020)

Article Biochemistry & Molecular Biology

Myricitrin Ameliorates Hyperglycemia, Glucose Intolerance, Hepatic Steatosis, and Inflammation in High-Fat Diet/Streptozotocin-Induced Diabetic Mice

Do Yeon Kim et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biotechnology & Applied Microbiology

Advances on the in vivo and in vitro glycosylations of flavonoids

Yuan Ji et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2020)

Article Immunology

The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study

Zijian Yan et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Medicine, Research & Experimental

Myricitrin inhibits vascular endothelial growth factor-induced angiogenesis of human umbilical vein endothelial cells and mice

Zhipeng Hu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Review Agricultural Engineering

Metabolic engineering for increased lipid accumulation in Yarrowia lipolytica -A Review

Jinpeng Wang et al.

BIORESOURCE TECHNOLOGY (2020)

Review Biochemistry & Molecular Biology

Recent Advances in Supercritical Fluid Extraction of Natural Bioactive Compounds from Natural Plant Materials

Pascaline Aimee Uwineza et al.

MOLECULES (2020)

Article Immunology

Myricitrin pretreatment ameliorates mouse liver ischemia reperfusion injury

Yuntai Shen et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

Article Food Science & Technology

LC-MS/MS screening and identification of bioactive compounds in leaves, pulp and seed from Eugenia calycina Cambess

Nayara Macedo Peixoto Araujo et al.

FOOD RESEARCH INTERNATIONAL (2020)

Article Integrative & Complementary Medicine

Inhibitory effect of Newtonia extracts and myricetin-3-o-rhamnoside (myricitrin) on bacterial biofilm formation

Katlego E. Motlhatlego et al.

BMC COMPLEMENTARY MEDICINE AND THERAPIES (2020)

Article Food Science & Technology

Enhancement of phenolic compounds extraction from grape pomace by high voltage atmospheric cold plasma

Yiwen Bao et al.

LWT-FOOD SCIENCE AND TECHNOLOGY (2020)

Article Tropical Medicine

Enzyme-treated date plum leave extract ameliorates atopic dermatitis-like skin lesion in hairless mice

Byoung Ok Cho et al.

ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE (2020)

Article Biochemistry & Molecular Biology

Myricitrin regulates proliferation, apoptosis and inflammation of chondrocytes treated with IL-1β

Tao Sun et al.

CELLULAR AND MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Inhibition of African swine fever virus protease by myricetin and myricitrin

Seri Jo et al.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2020)

Article Agricultural Engineering

Evaluation antithrombotic activity and action mechanism of myricitrin

Nan He et al.

INDUSTRIAL CROPS AND PRODUCTS (2019)

Article Pharmacology & Pharmacy

Effects of myricetin-3-O-α-rhamnoside (myricitrin) treatment on urinary parameters of Wistar rats

Adrielli Tenfen et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2019)

Review Chemistry, Multidisciplinary

Deep Eutectic Solvents as Extraction Media for Valuable Flavonoids from Natural Sources

Dimitris Skarpalezos et al.

APPLIED SCIENCES-BASEL (2019)

Article Food Science & Technology

Economic Feasibility of Soybean Oil Production by Enzyme-Assisted Aqueous Extraction Processing

Ming-Hsun Cheng et al.

FOOD AND BIOPROCESS TECHNOLOGY (2019)

Review Biochemistry & Molecular Biology

The Research Progress of Chalcone Isomerase (CHI) in Plants

Yan-chao Yin et al.

MOLECULAR BIOTECHNOLOGY (2019)

Article Public, Environmental & Occupational Health

Pouteria campechiana leaf extract and its bioactive compound myricitrin are mosquitocidal against Aedes aegypti and Culex quinquefasciatus

Raju Sangeetha et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2019)

Article Cell Biology

Antioxidant effect of myricitrin on hyperglycemia-induced oxidative stress in C2C12 cell

Akram Ahangarpour et al.

CELL STRESS & CHAPERONES (2018)

Article Food Science & Technology

Extraction of phenolic compounds from olive pomace by using natural deep eutectic solvents and innovative extraction techniques

Sofia Chanioti et al.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2018)

Review Chemistry, Physical

Strategies to improve micelle stability for drug delivery

Yang Lu et al.

NANO RESEARCH (2018)

Review Food Science & Technology

High intensity pulsed electric field as an innovative technique for extraction of bioactive compounds-A review

Liang-Gong Yan et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

Review Food Science & Technology

The role of dietary polyphenols in the moderation of the inflammatory response in early stage colorectal cancer

C. H. Little et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2017)

Article Food Science & Technology

Gastrointestinal stability of dihydromyricetin, myricetin, and myricitrin: an in vitro investigation

Dong Xiang et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION (2017)

Article Biochemical Research Methods

At-line hyphenation of high-speed countercurrent chromatography with Sephadex LH-20 column chromatography for bioassay-guided separation of antioxidants from vine tea (Ampelopsis grossedentata)

Ruyi Ma et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2017)

Article Plant Sciences

The isolation and functional characterization of three liverwort genes encoding cinnamate 4-hydroxylase

Xin-Yan Liu et al.

PLANT PHYSIOLOGY AND BIOCHEMISTRY (2017)

Review Oncology

Strategies for the evaluation of DNA damage and repair mechanisms in cancer

Gabriela Figueroa-Gonzalez et al.

ONCOLOGY LETTERS (2017)

Article Biotechnology & Applied Microbiology

Antithrombotic Effect and Mechanism of Radix Paeoniae Rubra

Pingyao Xie et al.

BIOMED RESEARCH INTERNATIONAL (2017)

Article Food Science & Technology

Antithrombotic mechanism of polysaccharides in Blackberry (Rubus spp.) seeds

Jinmei Wang et al.

FOOD & NUTRITION RESEARCH (2017)

Review Biochemistry & Molecular Biology

Induced dopaminergic neurons: A new promise for Parkinson's disease

Zhimin Xu et al.

REDOX BIOLOGY (2017)

Article Behavioral Sciences

Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice

Erika Meyer et al.

BEHAVIOURAL BRAIN RESEARCH (2017)

Article Medicine, Research & Experimental

Taraxerol, a pentacyclic triterpenoid, from Abroma augusta leaf attenuates diabetic nephropathy in type 2 diabetic rats

Ritu Khanra et al.

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Agricultural Engineering

Metabolic engineering of yeast for fermentative production of flavonoids

Angelica Rodriguez et al.

BIORESOURCE TECHNOLOGY (2017)

Review Food Science & Technology

Green Extraction Methods for Polyphenols from Plant Matrices and Their Byproducts: A Review

Kashif Ameer et al.

COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY (2017)

Article Chemistry, Multidisciplinary

Recovery of flavonoids from grape skins by enzyme-assisted extraction

Ivana Tomaz et al.

SEPARATION SCIENCE AND TECHNOLOGY (2016)

Review Biotechnology & Applied Microbiology

Recent developments in the enzymatic O-glycosylation of flavonoids

Bernd Hofer

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2016)

Article Gastroenterology & Hepatology

Pathogenesis and Management of Alcoholic Liver Disease

M. Omar Farooq et al.

DIGESTIVE DISEASES (2016)

Article Biochemistry & Molecular Biology

Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice

Robert Domitrovic et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2015)

Article Chemistry, Applied

Safety assessment and single-dose toxicokinetics of the flavouring agent myricitrin in Sprague-Dawley rats

Robert R. Maronpot et al.

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT (2015)

Article Food Science & Technology

Genotoxicity evaluation of the flavonoid, myricitrin, and its aglycone, myricetin

Cheryl A. Hobbs et al.

FOOD AND CHEMICAL TOXICOLOGY (2015)

Article Food Science & Technology

Influence of high-intensity pulsed electric field processing parameters on antioxidant compounds of broccoli juice

Rogelio Sanchez-Vega et al.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2015)

Review Gastroenterology & Hepatology

Alcoholic liver disease: mechanisms of injury and targeted treatment

Alexandre Louvet et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2015)

Article Biochemistry & Molecular Biology

Molecular cloning and characterization of the CHS gene family in turmeric (Curcuma longa Linn.)

Sirinrat Wannapinpong et al.

JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY (2015)

Review Biotechnology & Applied Microbiology

Advances in the biotechnological glycosylation of valuable flavonoids

Jianbo Xiao et al.

BIOTECHNOLOGY ADVANCES (2014)

Article Biochemistry & Molecular Biology

Improvement of Regio-Specific Production of Myricetin-3-O-α-l-Rhamnoside in Engineered Escherichia coli

Nguyen Huy Thuan et al.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2013)

Article Biochemistry & Molecular Biology

Synthesis of flavonol 3-O-glycoside by UGT78D1

Guangxiang Ren et al.

GLYCOCONJUGATE JOURNAL (2012)

News Item Biotechnology & Applied Microbiology

Toll-like receptor blocker slows beta cell death in type 1 diabetes

Susan Aldridge

NATURE BIOTECHNOLOGY (2012)

Review Chemistry, Analytical

Pressurized liquid extraction as a green approach in food and herbal plants extraction: A review

Arwa Mustafa et al.

ANALYTICA CHIMICA ACTA (2011)

Article Chemistry, Applied

Anti-allergic effect of the flavonoid myricitrin from Myrica rubra leaf extracts in vitro and in vivo

Shunsuke Shimosaki et al.

NATURAL PRODUCT RESEARCH (2011)

Review Clinical Neurology

Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models

M. Pereira et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2011)

Review Food Science & Technology

Microwave assisted extraction of secondary metabolites from plants: Current status and future directions

Hua-Feng Zhang et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2011)

Editorial Material Pharmacology & Pharmacy

Inflammation: Novel arrows for an ancient target

Cyril Sobolewski et al.

BIOCHEMICAL PHARMACOLOGY (2010)

Article Nutrition & Dietetics

Berry flavonoids and phenolics: bioavailability and evidence of protective effects

Daniele Del Rio et al.

BRITISH JOURNAL OF NUTRITION (2010)

Article Biotechnology & Applied Microbiology

The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells

Miguel Lopez-Lazaro et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2010)

Article Biochemical Research Methods

Measurement of superoxide dismutase, catalase and glutathione peroxidase in cultured cells and tissue

Christine J. Weydert et al.

NATURE PROTOCOLS (2010)

Article Biochemistry & Molecular Biology

The Flavonoid Glycosides, Myricitrin, Gossypin and Naringin Exert Anxiolytic Action in Mice

Sebastian P. Fernandez et al.

NEUROCHEMICAL RESEARCH (2009)

Article Psychiatry

Protein kinase C inhibition in the treatment of mania

Ayseguel Yildiz et al.

ARCHIVES OF GENERAL PSYCHIATRY (2008)

Review Biochemistry & Molecular Biology

Cell cycle control as a basis for cancer chemoprevention through dietary agents

Syed Musthapa Meeran et al.

FRONTIERS IN BIOSCIENCE-LANDMARK (2008)

Article Agriculture, Multidisciplinary

Online RP-HPLC-DPPH screening method for detection of radical-scavenging phytochemicals from flowers of Acacia confusa

Jyh-Horng Wu et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2008)

Article Pharmacology & Pharmacy

Involvement of p38MAPK on the antinociceptive action of myricitrin in mice

Flavia Carla Meotti et al.

BIOCHEMICAL PHARMACOLOGY (2007)

Article Pharmacology & Pharmacy

Antinociceptive action of myricitrin:: Involvement of the K+ and Ca2+ channels

Flavia Carla Meotti et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2007)

Article Pharmacology & Pharmacy

Anti-allodynic property of flavonoid myricitrin in models of persistent inflammatory and neuropathic pain in mice

Flavia Carla Meotti et al.

BIOCHEMICAL PHARMACOLOGY (2006)

Review Pharmacology & Pharmacy

Natural flavonoids targeting deregulated cell cycle progression in cancer cells

RP Singh et al.

CURRENT DRUG TARGETS (2006)

Review Psychiatry

The many faces of nitric oxide in schizophrenia. A review

HG Bernstein et al.

SCHIZOPHRENIA RESEARCH (2005)

Article Pharmacology & Pharmacy

The role of nitric oxide on glutaminergic modulation of dopaminergic activation

JT Hong et al.

PHARMACOLOGICAL RESEARCH (2005)

Article Plant Sciences

Absorption, bioavailability, and metabolism of flavonoids

PCH Hollman

PHARMACEUTICAL BIOLOGY (2004)

Article Plant Sciences

Bioactive novel polyphenols from the fruit of Manilkara zapota (Sapodilla)

J Ma et al.

JOURNAL OF NATURAL PRODUCTS (2003)

Article Engineering, Chemical

Estimation of characteristic damage time of food materials in pulsed-electric fields

NI Lebovka et al.

JOURNAL OF FOOD ENGINEERING (2002)

Article Agriculture, Multidisciplinary

Polyphenolic antioxidants from the fruits of Chrysophyllum cainito L. (star apple)

XD Luo et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2002)