Journal
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408398.2023.2266842
Keywords
Colonic targeting; polyphenols; controlled release; construction principles; delivery assessment
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This paper mainly introduces the research on colon-targeted controlled release of polyphenols, discusses the physiological features affecting the dissolution, release and absorption of polyphenol-loaded delivery systems in the colon, describes the types of colon-targeted carriers with different release mechanisms, and summarizes the colon-targeting assessment models that have been studied so far and their advantages and limitations. Based on the current research on polyphenols colon-targeting, outlook and reflections are proposed to inspire strategic development of new colon-targeted therapeutics.
Polyphenols have received considerable attention for their promotive effects on colonic health. However, polyphenols are mostly sensitive to harsh gastrointestinal environments, thus, must be protected. It is necessary to design and develop a colon-targeted delivery system to improve the stability, colon-targeting and bioavailability of polyphenols. This paper mainly introduces research on colon-targeted controlled release of polyphenols. The physiological features affecting the dissolution, release and absorption of polyphenol-loaded delivery systems in the colon are first discussed. Simultaneously, the types of colon-targeted carriers with different release mechanisms are described, and colon-targeting assessment models that have been studied so far and their advantages and limitations are summarized. Based on the current research on polyphenols colon-targeting, outlook and reflections are proposed, with the goal of inspiring strategic development of new colon-targeted therapeutics to ensure that the polyphenols reach the colon with complete bioactivity.
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