Food matrix-flavonoid interactions and their effect on bioavailability

Flavonoid compounds exhibit a wide range of health benefits as plant-derived dietary components. Typically, co-consumed with the food matrix,they must be released from the matrix and converted into an absorbable form (bioaccessibility) before reaching the small intestine, where they are eventually absorbed and transferred into the bloodstream (bioavailability) to exert their biological activity. However, a large number of studies have revealed the biological functions of individual flavonoid compounds in different experimental models, ignoring the more complex but common relationships established in the diet. Besides, it has been appreciated that the gut microbiome plays a crucial role in the metabolism of flavonoids and food substrates, thereby having a significant impact on their interactions, but much progress still needs to be made in this area. Therefore, this review intends to comprehensively investigate the interactions between flavonoids and food matrices, including lipids, proteins, carbohydrates and minerals, and their effects on the nutritional properties of food matrices and the bioaccessibility and bioavailability of flavonoid compounds. Furthermore, the health effects of the interaction of flavonoid compounds with the gut microbiome have also been discussed.

Automated summary

Flavonoid compounds play a significant role in promoting health, but current research focuses mainly on their individual functions rather than their complex relationships in food. The gut microbiome is also important in the metabolism of flavonoids, but more progress is needed in this area. This review examines the interactions between flavonoids and food matrices, and their effects on the nutritional properties and bioavailability of flavonoid compounds. The health effects of the interaction between flavonoids and the gut microbiome are also discussed.