Journal
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
Volume -, Issue -, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/10408347.2023.2276294
Keywords
Analytical method; greenness assessment; GAPI tool; AGREE metric; analytical eco-scale
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The main difficulties in analyzing pharmaceutically active compounds in solid environmental samples are the complexity of the samples and the low concentration levels of such pollutants. This study applied the Analytical Eco-scale, Green Analytical Procedure Index (GAPI), and Analytical GREEnness metric (AGREE) to evaluate the greenness of nine analytical procedures. The results showed that the paper spray ionization method was the greenest procedure, while the use of internal standards had a contradictory environmental impact. The gaps in incorporating validation analytical features in greenness metrics were also discussed.
The main difficulties when analyzing pharmaceutically active compounds (PhACs) in solid environmental samples is the complexity of the samples and the low concentration levels of such pollutants. Most efforts are focused in achieving good analytical performance parameters such as high recoveries or low detection limits without considering if the methods are environmentally friendly. In this work, the main tools proposed for assessing the greenness of analytical methodologies (Analytical Eco-scale, Green Analytical Procedure Index (GAPI), and Analytical GREEnness metric (AGREE)) have been applied to nine analytical procedures that include recent important analytical tendencies. The three metrics identified the paper spray ionization method as the greenest procedure since it used untreated samples for direct mass spectrometry analysis. Using Analytical Eco-scale, most of the evaluated procedures were rated as acceptable green. However, the use of internal standards resulted key in the environmental impact of the method which provided contradictory results versus other metrics. GAPI found greenness similarities between most of selected methods, hindering a greenness classification. AGREE allowed the weighting of each evaluation criterion providing a greenness ranking. The application of each metric detecting their weaknesses and strengths was discussed. The incorporation of validation analytical features in greenness metrics was a gap revealed.
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