Should acetophenone azine be inserted in a baseline patch test series?

Article Allergy

Sensitization properties of acetophenone azine, a new skin sensitizer identified in textile

Isabelle Maniere et al.

Summary: Twelve case reports from Europe and North America confirmed that acetophenone azine, found in sports equipment, is suspected to cause skin allergies. In vitro and in vivo tests based on the Adverse Outcome Pathway (AOP) built for skin sensitization by OECD in 2012 were conducted to confirm its skin sensitization properties. The results showed positive reactions in the in vitro tests and negative reactions in the in vivo test. As a result, acetophenone azine was classified as a skin sensitizer under the CLP regulation.

CONTACT DERMATITIS (2023)

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Article Dermatology

Acetophenone Azine

Nadia Raison-Peyron et al.

Summary: Acetophenone azine, a potent allergen found in footwear with ethyl vinyl acetate foam, is likely a byproduct of reactions between additives during manufacturing. Patch testing with a concentration of 0.1% is recommended, but the compound is not currently available from suppliers. It should be included in shoe, plastics, and glues series for patch testing.

DERMATITIS (2021)

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Letter Dermatology