Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 46, Pages 9543-9546Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc02594j
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Funding
- Chinese National Key Basic Research and Development (973) Program [2013CB127200]
- NSFC-Shandong Joint Fund for Marine Science Research Centers [U1406402]
- National Natural Science Foundation of China [NSFC21171154]
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We report the discovery of a promising NDM-1 inhibitor, ebselen, through a cell-based screening approach. Enzymatic kinetic study and ESI-MS analysis suggested that ebselen could bind to NDM-1 by forming a S-Se bond with the Cys(221) residue at the active site, thereby exhibiting a new inhibition mechanism with broad spectrum inhibitory potential.
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