Journal
COMPARATIVE MEDICINE
Volume 73, Issue 4, Pages 311-322Publisher
AMER ASSOC LABORATORY ANIMAL SCIENCE
DOI: 10.30802/AALAS-CM-22-000097
Keywords
-
Categories
Ask authors/readers for more resources
In this study, a porcine cholecystic extracellular matrix was used to treat nonfatal myocardial infarction in rats. The graft-assisted healing reduced fibrosis and promoted regenerative reaction and angiogenesis.
Fibrosis that occurs after nonfatal myocardial infarction (MI) is an irreversible reparative cardiac tissue remodeling process characterized by progressive deposition of highly cross-linked type I collagen. No currently available therapeutic strategy prevents or reverses MI-associated fibrotic scarring of myocardium. In this study, we used an epicardial graft prepared of porcine cholecystic extracellular matrix to treat experimental nonfatal MI in rats. Graft-assisted healing was characterized by reduced fibrosis, with scanty deposition of type I collagen. Histologically, the tissue response was associated with a favorable regenerative reaction predominated by CD4-positive helper T lymphocytes, enhanced angiogenesis, and infiltration of proliferating cells. These observations indicate that porcine cholecystic extracellular matrix delayed the fibrotic reaction and support its use as a potential biomaterial for mitigating fibrosis after MI. Delaying the progression of cardiac tissue remodeling may widen the therapeutic window for management of scarring after MI.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available