Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 43, Pages 8958-8961Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01676b
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Funding
- Ministerio de Economia y Competitividad (MINECO-Gobierno de Espana)
- FEDER (EU) [CTQ2013-47494-P]
- Generalitat Valenciana [ISIC2012/001]
- MINECO
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The conjugate diynylation of alpha,beta-unsaturated trifluoromethyl ketones is carried out in the presence of a low catalytic load (2.5 mol%) of a copper(I)-MeOBIPHEP complex, triethylamine and a terminal 1,3-diyne. Pre-metalation of the terminal 1,3-diyne with stoichiometric or higher amounts of dialkylzinc reagent is not required. The corresponding internal diynes bearing a propargylic stereogenic center are obtained with good yields and excellent enantioselectivities.
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