Model-Informed Dosing Regimen of Ticagrelor in Chinese Patients With Acute Coronary Syndrome

Article Medicine, Research & Experimental

Comparison of Net Clinical Benefit Between Clopidogrel and Ticagrelor Following Percutaneous Coronary Intervention in Patients in China With Acute Coronary Syndrome

Dandan Li et al.

Summary: In Chinese ACS patients undergoing PCI with second-generation DESs, outpatient use of clopidogrel dual antiplatelet therapy was associated with a reduction in NACCE and bleeding compared to ticagrelor therapy.

ADVANCES IN THERAPY (2022)

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Editorial Material Pharmacology & Pharmacy

Perspectives on Model-Informed Precision Dosing in the Digital Health Era: Challenges, Opportunities, and Recommendations

Franziska Kluwe et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Clinical Neurology

Association with CYP2C19 polymorphisms and Clopidogrel in treatment of elderly stroke patients

Changqing Li et al.

Summary: This retrospective analysis of elderly stroke patients aged over 75 years receiving 75 mg clopidogrel showed that a CYP2C19 genotype-guided strategy could reduce the occurrence of composite of stroke and myocardial infarction compared to a non-genotype-guided strategy.

BMC NEUROLOGY (2021)

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Review Pharmacology & Pharmacy

From Therapeutic Drug Monitoring to Model-Informed Precision Dosing for Antibiotic

Sebastian G. Wicha et al.

Summary: Therapeutic drug monitoring (TDM) and model-informed precision dosing (MIPD) are crucial for individualized dosing in critically ill patients with infections. The use of MIPD software and new technologies has the potential to revolutionize antibiotic dosing, but more clinical trials are needed to validate their effectiveness.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Pharmacology & Pharmacy

Mycophenolic Acid Exposure Prediction Using Machine Learning

Jean-Baptiste Woillard et al.

Summary: This study utilized machine learning models to accurately estimate the area under the curve (AUC) of mycophenolic acid (MPA) in organ transplant patients, showing better performance than Bayesian estimation and potential for routine exposure estimation and dose adjustment.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Article Multidisciplinary Sciences

Incidence and predictors of serious bleeding during long-term follow-up after acute coronary syndrome in a population-based cohort study

Anna Graipe et al.

Summary: Bleeding complications post ACS, particularly gastrointestinal bleeding, were frequent in this study. Older age, lower baseline hemoglobin, hypertension, and heart failure were predictive factors for bleeding events. Importantly, bleeding independently predicted increased mortality.

SCIENTIFIC REPORTS (2021)

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Editorial Material Pharmacology & Pharmacy

Machine Learning as a Novel Method to Support Therapeutic Drug Management and Precision Dosing

Teun van Gelder et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2021)

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Review Pharmacology & Pharmacy

Model-informed precision dosing to optimise immunosuppressive therapy in renal transplantation

Tom C. Zwart et al.

Summary: Immunosuppressive therapy is crucial for sustained allograft and patient survival after renal transplantation. However, variability in pharmacokinetics between patients and within patients poses challenges for optimal dosing, necessitating personalized dosing strategies to optimize outcomes. Pharmacometrics offers mathematical modeling to describe and quantify this variability, guiding dosing of immunosuppressants in modern renal transplantation.

DRUG DISCOVERY TODAY (2021)

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Review Pharmacology & Pharmacy