False-Positive Ga-68-DOTATATE Uptake in a Uterine Subserosal Fibroid Mimicking Mesenteric Neuroendocrine Tumor A Case Study

Ga-68-DOTATATE PET/CT is a highly sensitive and specific imaging modality in detecting neuroendocrine tumors. False-positive DOTATATE uptake poses diagnostic challenges. False-positive uptake in a uterine fibroid is the third most common location. We report the case of a 45-year-old woman with clinical concern for possible neuroendocrine tumor showing moderate focal DOTATATE uptake, which was initially thought of to be localized to mesentery on PET/CT images but was subsequently localized to a subserosal uterine fibroid following MRI. Patient underwent hysterectomy, further confirming that the uterine myometrial uptake is within the subserosal fibroid.

Automated summary

Ga-68-DOTATATE PET/CT is a sensitive and specific imaging method for detecting neuroendocrine tumors. False-positive uptake in a uterine fibroid is a common issue. We present a case of a 45-year-old woman with focal DOTATATE uptake initially thought to be in the mesentery but later localized to a subserosal uterine fibroid on MRI. Hysterectomy further confirmed that the uterine myometrial uptake was within the fibroid.