Estimating motor unit numbers from a CMAP scan: Repeatability study on three muscles at 15 centres

Article Clinical Neurology

MScanFit motor unit number estimation of human anconeus muscle

Ya Zong et al.

Summary: The aim of this study was to estimate the number of motor units in the anconeus muscle, and the results showed a relatively low motor unit number, which has not been comprehensively studied.

MUSCLE & NERVE (2022)

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Article Clinical Neurology

Automatic detection of F waves and F-MUNE in two types of motor neuron diseases

Emel Oguz-Akarsu et al.

Summary: This study assessed the sensitivity of F-MUNE values in motor neuron diseases using newly developed software. The results showed higher sMUAP amplitudes and lower F-MUNE values in patients compared to controls. F-MUNE values were able to distinguish patients from controls, and significant correlations were found between F-MUNE and MScanFit in the patient groups.

MUSCLE & NERVE (2022)

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Article Clinical Neurology

Assessing inter-rater reproducibility in MScanFit MUNE in a 6-subject, 12-rater Round Robin setup

Daniel Mosgaard Sorensen et al.

Summary: The study assessed the inter-rater reliability of MScanFit MUNE and found that it was high even with limited rater experience. The method was well tolerated by patients and showed potential as a reliable MUNE method and a biomarker in drug trials.

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY (2022)

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Article Clinical Neurology

Estimating the motor unit number of the flexor carpi ulnaris muscle with MScanFit MUNE

Halil Can Alaydin et al.

Summary: This study demonstrates that MScanFit MUNE is a feasible method with good reproducibility for motor unit number estimation (MUNE) of the flexor carpi ulnaris muscle.

MUSCLE & NERVE (2022)

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Article Clinical Neurology

Feasibility and reliability of MScanFit motor unit number estimation in peroneus longus muscle

Deniz Alp Tankisi et al.

Summary: The MScanFit method for estimating motor unit numbers in the peroneus longus muscle is feasible and highly reliable in healthy subjects. There is no significant correlation between MScanFit MUNE and CMAP amplitude, highlighting the need for further research on its sensitivity in disease states.

MUSCLE & NERVE (2022)

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Article Clinical Neurology

Changes in neuromuscular function in elders: Novel techniques for assessment of motor unit loss and motor unit remodeling with aging

A. Verschueren et al.

Summary: Functional muscle fiber denervation is a major contributor to the decline in physical function observed with aging, and it is also a recognized cause of sarcopenia. The relationship between muscle strength, motor unit number, and aging suggests that the loss of functional motor units may contribute to muscle weakness in seniors. The aging process involves a progression of motor unit loss, followed by adaptive and maladaptive sprouting, and a reduction in compensatory reinnervation capacity. In amyotrophic lateral sclerosis, older onset age predicts worse survival, possibly due to age-related depletion of the motor neuron pool. MUNE methods and MU-MRI technique are used to evaluate motor unit loss and remodeling. This review summarizes studies on neuromuscular function changes in aging and highlights the use of these two novel techniques.

REVUE NEUROLOGIQUE (2022)

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Article Geriatrics & Gerontology

MScanFit motor unit number estimation of abductor pollicis brevis: Findings from different experimental parameters

Ya Zong et al.

Summary: This study evaluated the effect of different CMAP scan settings on MScanFit motor unit number estimation (MUNE). The results showed that a shorter pulse width led to a higher MUNE, while the number of steps had no effect on MUNE. Additionally, the MUNE of participants in the China research center was significantly higher than that of participants in the US center, despite using the same pulse widths and steps. This difference is speculated to be partly related to the different electrode sizes used in the two centers.

FRONTIERS IN AGING NEUROSCIENCE (2022)

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Article Clinical Neurology

Advancing disease monitoring of amyotrophic lateral sclerosis with the compound muscle action potential scan

Boudewijn T. H. M. Sleutjes et al.

Summary: The study aimed to determine the most sensitive electrophysiological markers derived from CMAP scans for monitoring ALS progression, with MUNE showing potential as the most suitable marker. Results indicated that MUNE could increase clinical trial efficiency compared to traditional clinical endpoints.

CLINICAL NEUROPHYSIOLOGY (2021)

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Article Clinical Neurology