Abnormalities in the face primary motor cortex in oromandibular dystonia

Objective: To comprehensively investigate excitability in face and hand M1 and sensorimotor integration in oromandibular dystonia (OMD) patients.Methods: Short-interval intracortical inhibition (SICI), intracortical facilitation (ICF), short (SAI) and long (LAI) afferent inhibition were investigated in face and hand M1 using transcranial magnetic stimulation protocols in 10 OMD patients. Data were compared with those obtained in 10 patients with focal hand dystonia (FHD), in 10 patients with blepharospasm (BSP), and 10 matched healthy subjects (HS).Results: Results demonstrated that in OMD patients SICI was reduced in face M1 (p < 0.001), but not in hand M1, compared to HS. In FHD, SICI was significantly impaired in hand M1 (p = 0.029), but not in face M1. In BSP, SICI was normal in both face and hand M1 while ICF and LAI were normal in all patient groups and cortical area tested. SAI was significantly reduced (p = 0.003) only in the face M1 of OMD patients.Conclusions: In OMD, SICI and SAI were significantly reduced. These abnormalities are specific to the motor cortical area innervating the muscular district involved in focal dystonia.Significance: In OMD, the integration between sensory inflow and motor output seem to be disrupted at cortical level with topographic specificity.& COPY; 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.

Automated summary

The objective of this study was to investigate excitability in face and hand motor cortex and sensorimotor integration in patients with oromandibular dystonia (OMD). The results demonstrated that abnormalities in short-interval intracortical inhibition (SICI) and short afferent inhibition (SAI) were specific to the motor cortical area innervating the muscular district involved in focal dystonia. These findings suggest disrupted integration between sensory inflow and motor output at the cortical level in OMD patients.