US Guidelines Fall Short on Short-Course Tuberculosis-Preventive Therapy

The provision of tuberculosis-preventive therapy (TPT) to vulnerable populations is critical for global control. Shorter-course TPT regimens are highly effective and improve completion rates. Despite incorporation of 1 month of rifapentine and isoniazid into global guidelines, current US TPT guidelines do not include this as a recommended regimen, but should.

Automated summary

In the global control of tuberculosis, providing tuberculosis-preventive therapy (TPT) to vulnerable populations is crucial. Shorter-course TPT regimens are highly effective and improve completion rates. Despite the inclusion of one month of rifapentine and isoniazid in global guidelines, current US TPT guidelines do not recommend this regimen, but they should.