Uncertainty in measurement and the renal tubular reabsorption of phosphate

Editorial Material Medical Laboratory Technology

Commentary on Severe Hypophosphatemia: The Hidden Truth

Amish Chinoy et al.

CLINICAL CHEMISTRY (2023)

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Editorial Material Medical Laboratory Technology

Severe Hypophosphatemia: The Hidden Truth

Farzahna Mohamed et al.

CLINICAL CHEMISTRY (2023)

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Article Urology & Nephrology

Assessment of Proximal Tubular Function by Tubular Maximum Phosphate Reabsorption Capacity in Heart Failure

Johanna E. Emmens et al.

Summary: By studying 2085 patients with heart failure, we found that proximal tubular function is frequently reduced in these patients, and this reduction is associated with an increased risk of plasma NGAL doubling and worse clinical outcomes, independent of glomerular function. In addition, inhibition of SGLT2 by empagliflozin and improvement of TmP/GFR may have a positive effect in patients with heart failure.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2022)

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Article Transplantation

Tubular phosphate handling: references from child to adulthood in the era of standardized serum creatinine

Laurence Derain Dubourg et al.

Summary: This study retrospectively analyzed the TmP/GFR values of 2051 subjects with normal GFR, phosphate, and calcium levels, ranging from children under 19 years old to adults. Results showed a gradual decrease in plasma phosphate and TmP/GFR during puberty in both genders, with levels stabilizing after the age of 19 until 55, slightly lower in men than in women.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2022)

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Letter Medical Laboratory Technology

Measurement uncertainty estimation for derived biological quantities

Raul Rigo-Bonnin et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Editorial Material Medical Laboratory Technology

Measurement uncertainty and the importance of correlation

Ian Farrance et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Article Endocrinology & Metabolism

Renal Phosphate Handling: Independent Effects of Circulating FGF23, PTH, and Calcium

Malachi J. McKenna et al.

Summary: This study investigated the effects of FGF23, PTH, and calcium on TmP/GFR, finding that hypoparathyroidism can ameliorate the effects of FGF23 excess. The analysis revealed complex relationships among these physiological indicators, particularly during PTH deficiency.

JBMR PLUS (2021)

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Article Medical Laboratory Technology