4.6 Article

Evaluation of the analytical and clinical performance of a new high-sensitivity cardiac troponin I assay: hs-cTnI (CLIA) assay

Related references

Note: Only part of the references are listed.
Article Medical Laboratory Technology

Antibody-mediated interferences affecting cardiac troponin assays: recommendations from the IFCC Committee on Clinical Applications of Cardiac Biomarkers

Ola Hammarsten et al.

Summary: The IFCC C-CB provides educational materials to help interpret and use cardiac biomarkers in clinical laboratories and practice. Their aim is to improve understanding of key analytical and clinical aspects of cardiac biomarkers and their interplay. Two emerging analytical issues causing falsely high cTn concentrations are antibody-mediated assay interference (macrotroponin) and crosslinking antibodies (heterophilic antibodies). They provide an overview of these interference issues and recommendations on confirmation and interpretation of results.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Medical Laboratory Technology

Variability of cardiac troponin levels in normal subjects and in patients with cardiovascular diseases: analytical considerations and clinical relevance A consensus document by the Study Group on Cardiac Biomarkers from Italian Society of Biochemical Chemistry (SIBioC) and European Ligand Assay Society (ELAS)

Aldo Clerico et al.

Summary: In accordance with international guidelines, the use of high-sensitivity methods to measure the variation of cardiac troponins I and T (hs-cTnI and hs-cTnT) is recommended for detecting acute myocardial injury. These variations in circulating levels are important for diagnosing Acute Coronary Syndromes (ACS), evaluating cardiovascular risk in surgical and asymptomatic populations, and assessing cardiotoxicity caused by chemotherapy. This document examines the statistical and biological considerations of the intra-individual variability of hs-cTnI and hs-cTnT, as well as their clinical relevance in specific conditions. It proposes the evaluation of hs-cTnI and hs-cTnT variations over time for more accurate cardiovascular risk estimation in asymptomatic individuals.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2023)

Article Cardiac & Cardiovascular Systems

2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Jean-Philippe Collet et al.

EUROPEAN HEART JOURNAL (2021)

Article Medical Laboratory Technology

Discrepancy between Cardiac Troponin Assays Due to Endogenous Antibodies

Leo Lam et al.

CLINICAL CHEMISTRY (2020)

Letter Medical Laboratory Technology

Grossly Elevated False-Positive High-Sensitivity Troponin I Due to Heterophilic Antimouse IgG1 Antibodies

John G. Lewis et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2020)

Article Medicine, Research & Experimental

Trial design for assessing analytical and clinical performance of high-sensitivity cardiac troponin I assays in the United States: The HIGH-US study

R. H. Christenson et al.

CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS (2019)

Article Cardiac & Cardiovascular Systems

Fourth Universal Definition of Myocardial Infarction (2018)

Kristian Thygesen et al.

CIRCULATION (2018)

Review Medical Laboratory Technology

Application of Cardiac Troponin in Cardiovascular Diseases Other Than Acute Coronary Syndrome

Kai M. Eggers et al.

CLINICAL CHEMISTRY (2017)

Editorial Material Medical Laboratory Technology

Troponin Autoantibodies: From Assay Interferent to Mediator of Cardiotoxicity

Jason Y. Park et al.

CLINICAL CHEMISTRY (2017)

Review Medicine, General & Internal

Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin

Pankaj Garg et al.

INTERNAL AND EMERGENCY MEDICINE (2017)

Article Medical Laboratory Technology

High incidence of macrotroponin I with a high-sensitivity troponin I assay

Janet V. Warner et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2016)

Review Biophysics

Diagnostics on acute myocardial infarction: Cardiac troponin biomarkers

M. F. M. Fathil et al.

BIOSENSORS & BIOELECTRONICS (2015)

Article Medical Laboratory Technology

European multicenter analytical evaluation of the Abbott ARCHITECT STAT high sensitive troponin I immunoassay

Magdalena Krintus et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2014)

Article Endocrinology & Metabolism

Heterophilic antibody interference in immunometric assays

Nils Bolstad et al.

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

Review Biochemistry & Molecular Biology

Human cardiac troponin complex. Structure and functions

I. A. Katrukha

BIOCHEMISTRY-MOSCOW (2013)

Article Medical Laboratory Technology

Outliers as a Cause of False Cardiac Troponin Results: Investigating the Robustness of 4 Contemporary Assays

Carel J. Pretorius et al.

CLINICAL CHEMISTRY (2011)

Editorial Material Cardiac & Cardiovascular Systems

Recommendations for the use of cardiac troponin measurement in acute cardiac care(dagger)

Kristian Thygesen et al.

EUROPEAN HEART JOURNAL (2010)

Review Cardiac & Cardiovascular Systems

Anti-troponin autoantibodies and the cardiovascular system

U. Nussinovitch et al.

HEART (2010)

Review Pathology

Standardisation of cardiac troponin I measurement: past and present

Jillian R. Tate et al.

PATHOLOGY (2010)

Review Medical Laboratory Technology

Standardization of troponin I measurements: an update

Mauro Panteghini et al.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2008)