Journal
CLINICAL CANCER RESEARCH
Volume 29, Issue 18, Pages 3560-3562Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-23-1389
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CD49d, the alpha chain of VLA-4 integrin, has a negative impact in CLL patients treated with BTK inhibitors. Evaluating CD49d expression can improve prognostic stratification.
CD49d, the alpha chain of the very late antigen- 4 (VLA-4) integrin, has a negative prognostic impact in chronic lymphocytic leukemia treated with the Bruton's tyrosine kinase (BTK) inhibitors, ibrutinib and acalabrutinib. Despite BTK inhibition, VLA-4 remains inside-out activated via B-cell receptor, an activation dampened by phosphoinositide 3-kinase inhibitors. Evaluation of CD49d expression in patients starting BTK inhibitor therapy may improve their prognostic stratification.
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