Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 36, Pages 7626-7628Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc01309g
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Funding
- ERC
- BBSRC [BBS/E/J/000CA512] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/J/000CA512] Funding Source: researchfish
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Here we report the discovery of a cytochrome P450 that is required for the biosynthesis of vindoline, a plant-derived natural product used for semi-synthesis of several anti-cancer drugs. This enzyme catalyzes the formation of an epoxide that can undergo rearrangement to yield the vincamine-eburnamine backbone, thereby providing evidence for the long-standing hypothesis that the aspidosperma- and eburnamine-type alkaloids are biosynthetically related.
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