Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 33, Pages 7242-7244Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cc00742a
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Funding
- National Institutes of Health [R01 GM098922, R01 GM106024, P30 GM103450, P20 GM103429, UL1TR000039]
- UAMS Research Council
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Using a G-quadruplex bait, we identified the transcription co-activator Sub1 as a G-quadruplex binding protein by quantitative LC-MS/MS and demonstrated in vivo G-quadruplex binding by ChIP. In vitro, Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes. This provides a possible mechanism by which G-quadruplexes can influence gene transcription.
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