For One Night Only Are Single-Night Studies Sufficient to Predict Risk of Hypertension in OSA?

Article Critical Care Medicine

Single-Night Diagnosis of Sleep Apnea Contributes to Inconsistent Cardiovascular Outcome Findings

Bastien Lechat et al.

Summary: Multinight quantification of OSA severity provides more precise estimates of associations with incident hypertension compared to single-night quantification. It allows for better assessment of hypertension risk and has important implications for clinical care and OSA trial design.

CHEST (2023)

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Article Critical Care Medicine

Multinight Prevalence, Variability, and Diagnostic Misclassification of Obstructive Sleep Apnea

Bastien Lechat et al.

Summary: Recent studies suggest that the severity of obstructive sleep apnea (OSA) can vary significantly from night to night, which has important implications for diagnosis and management. This study used a novel under-mattress sleep analyzer to assess OSA prevalence from multinight in-home recordings in a large community sample. The findings reveal a global prevalence of moderate to severe OSA of approximately 20%, and approximately 20% of people diagnosed with a single-night study may be misclassified. These findings emphasize the importance of considering night-to-night variation in OSA diagnosis and management.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Critical Care Medicine

Assessing the Physiologic Endotypes Responsible for REM- and NREM-Based OSA

Simon A. Joosten et al.

Summary: This study is the first to link the commonly seen polysomnographic patterns of OSA to underlying physiologic differences, showing that patients with NREMOSA have higher loop gain in NREM sleep, while patients with REMOSA have a worsening of Vpassive in REM sleep.

CHEST (2021)

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Review Respiratory System