Monitoring Biologic Therapy in Asthma Using Functional Imaging

Article Critical Care Medicine

CT Mucus Score and 129Xe MRI Ventilation Defects After 2.5 Years Anti-IL-5Ra in Eosinophilic Asthma '

Marrissa J. McIntosh et al.

Summary: In patients with poorly controlled eosinophilic asthma, early MRI VDP responses at 28 days post-benralizumab persisted 2.5 years later, along with significantly improved mucus scores. The ACQ-6 score improved after 1 year and 2.5 years, and the mucus score showed significant improvement at 2.5 years.

CHEST (2023)

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Review Respiratory System

Development of Core Outcome Measures sets for paediatric and adult Severe Asthma (COMSA)

Ekaterina Khaleva et al.

Summary: The COMSA Working Group developed two Core Outcome Measures (COM) sets for paediatric and adult severe asthma, including FEV1 as z-scores, frequency of severe exacerbations and oral corticosteroid use. These COM sets will inform future clinical trials, enhance comparability of biological therapies' efficacy and effectiveness, and assess their socioeconomic value.

EUROPEAN RESPIRATORY JOURNAL (2023)

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Article Critical Care Medicine

Mucus Plugs Persist in Asthma, and Changes in Mucus Plugs Associate with Changes in Airflow over Time

Monica Tang et al.

Summary: This study found that mucus plugs can serve as a persistent phenotype of asthma, and both subjects and bronchopulmonary segments are susceptible to mucus plugs. The relationship between changes in mucus plug scores and changes in airflow over time supports the causal role of mucus plugs in mechanisms of airflow obstruction in asthma.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Mucus Plugs in Asthma at CT Associated with Regional Ventilation Defects at 3He MRI

David G. Mummy et al.

Summary: This study assessed the relationship between airway mucus plugs and ventilation defects observed at hyperpolarized helium 3 MRI in asthma patients. The results showed a significant association between mucus plugs and ventilation defects, suggesting that mucus plugging may be an important cause of ventilation abnormalities in asthma.

RADIOLOGY (2022)

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Article Critical Care Medicine

Asthma Control, Airway Mucus, and 129Xe MRI Ventilation After a Single Benralizumab Dose

Marrissa J. McIntosh et al.

Summary: This study demonstrates that Xe-129 MRI can detect improved airway functional responses in asthma patients after a single dose of benralizumab, and this improvement is associated with airway mucus occlusions.

CHEST (2022)

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Article Respiratory System

Xenon ventilation MRI in difficult asthma: initial experience in a clinical setting

Grace T. Mussell et al.

Summary: Hyperpolarised gas MRI is a useful tool in assessing ventilation patterns in clinical care, showing correlation with spirometry measures in severe asthma patients. Discordance between MRI imaging and clinical metrics may indicate the need for diagnostic re-evaluation in some cases.

ERJ OPEN RESEARCH (2021)

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Article Critical Care Medicine