Journal
CHEMPHYSCHEM
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.202200809
Keywords
core-shell; gold nanostars; photothermal therapy; plasmonics; SERS
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A multifunctional core-shell nanostructure of silicon oxide@noble metal was synthesized and demonstrated to have dual applications in SERS enhancement and photothermal annihilation of breast cancer cells.
Core-shell nanostructures of silicon oxide@noble metal have drawn a lot of interest due to their distinctive characteristics and minimal toxicity with remarkable biocompatibility. Due to the unique property of localized surface plasmon resonance (LSPR), plasmonic nanoparticles are being used as surface-enhanced Raman scattering (SERS) based detection of pollutants and photothermal (PT) agents in cancer therapy. Herein, we demonstrate the synthesis of multifunctional silica core - Au nanostars shell (SiO2@Au NSs) nanostructures using surfactant free aqueous phase method. The SERS performance of the as-synthesized anisotropic core-shell NSs was examined using Rhodamine B (RhB) dye as a Raman probe and resulted in strong enhancement factor of 1.37x106. Furthermore, SiO2@Au NSs were also employed for PT killing of breast cancer cells and they exhibited a concentration-dependent increase in the photothermal effect. The SiO2@Au NSs show remarkable photothermal conversion efficiency of up to 72 % which is unprecedented. As an outcome, our synthesized NIR active SiO2@Au NSs are of pivotal importance to have their dual applications in SERS enhancement and PT effect. The synthesis of multifunctional silica core-Au nanostars shell and its application in SERS enhancement and photothermal annihilation of breast cancer cells is reported.image
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