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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
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BMC CARDIOVASCULAR DISORDERS (2010)
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EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
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EUROPEAN JOURNAL OF PHARMACOLOGY (2010)
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JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
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JOURNAL OF NEUROSCIENCE (2010)
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NATURE NEUROSCIENCE (2010)
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INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY (2008)
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management
Arthur Gomtsyan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Stereospecific high-affinity TRPV1 antagonists:: Chiral N-(2-benzyl-3-pivaloyloxypropyl) 2-[4-(methylsulfonylamino)phenyl]propionamide analogues
HyungChul Ryu et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
The TRPV1 receptor is associated with preferential stress in large dorsal root ganglion neurons in early diabetic sensory neuropathy
Shuangsong Hong et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Short Interfering RNA against Transient Receptor Potential Vanilloid 1 Attenuates Cisplatin-Induced Hearing Loss in the Rat
Debashree Mukherjea et al.
JOURNAL OF NEUROSCIENCE (2008)
Antihyperalgesic effects of (R,E)-N-(2-hydroxy-2,3-dihydro-1H-inden-4-yl)-3-(2-(piperidin-1-yl)-4-(trifluoromethyl)phenyl)acrylamide (AMG8562), a novel transient receptor potential vanilloid type 1 modulator that does not cause hyperthermia in rats
Sonya G. Lehto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) blocks polymodal activation of transient receptor potential vanilloid 1 receptors in vitro and heat-evoked firing of spinal dorsal horn neurons in vivo
Carol S. Surowy et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2008)
Influence of TRPVI on diabetes-induced alterations in thermal pain sensitivity
Reddy M. Pabbidi et al.
MOLECULAR PAIN (2008)
TRPV1 shows dynamic ionic selectivity during agonist stimulation
Man-Kyo Chung et al.
NATURE NEUROSCIENCE (2008)
Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150
Xuming Zhang et al.
NEURON (2008)
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors
Nikita B. Ruparel et al.
PAIN (2008)
Lack of TRPV1 inhibits cystitis-induced increased mechanical sensitivity in mice
Zun-Yi Wang et al.
PAIN (2008)
Structure of TRPV1 channel revealed by electron cryomicroscopy
Vera Y. Moiseenkova-Bell et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1
Narender R. Gavva
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
The emerging role of TRPV1 in diabetes and obesity
Anish Suri et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2008)
Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways
Katarzyna Starowicz et al.
JOURNAL OF NEUROSCIENCE (2007)
TRPM8 mechanism of cold allodynia after chronic nerve injury
Hong Xing et al.
JOURNAL OF NEUROSCIENCE (2007)
The effects of the TRPV1 antagonist SB-705498 on TRPV1 receptor-mediated activity and inflammatory hyperalgesia in humans
Boris A. Chizh et al.
PAIN (2007)
Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
Alexander M. Binshtok et al.
NATURE (2007)
'Sensing' autoimmunity in type 1 diabetes
Hubert Tsui et al.
TRENDS IN MOLECULAR MEDICINE (2007)
The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis
A. Miranda et al.
NEUROSCIENCE (2007)
Bone cancer increases transient receptor potential vanilloid subfamily 1 expression within distinct subpopulations of dorsal root ganglion neurons
Y. Niiyama et al.
NEUROSCIENCE (2007)
Expression of transient receptor potential vanilloid 1 (TRPV1) in synovial fibroblasts from patients with osteoarthritis and rheumatoid arthritis
Andrea Engler et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Nonthermal activation of transient receptor potential vanilloid-1 channels in abdominal viscera tonically inhibits autonomic cold-defense effectors
Alexandre A. Steiner et al.
JOURNAL OF NEUROSCIENCE (2007)
The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity
Polina V. Lishko et al.
NEURON (2007)
Differential expression of the capsaicin receptor TRPV1 and related novel receptors TRPV3, TRPV4 and TRPM8 in normal human tissues and changes in traumatic and diabetic neuropathy
Paul Facer et al.
BMC NEUROLOGY (2007)
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
Arpad Szallasi et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Activation of transient receptor potential vanilloid type-1 channel prevents adipogenesis and obesity
Li Li Zhang et al.
CIRCULATION RESEARCH (2007)
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation
Narender R. Gavva et al.
JOURNAL OF NEUROSCIENCE (2007)
Expression of transient receptor potential vanilloid 1 (TRPV1) and 2 (TRPV2) in human peripheral blood
Cassandra I. M. Saunders et al.
MOLECULAR IMMUNOLOGY (2007)
TRPV1+ sensory neurons control β cell stress and islet inflammation in autoimmune diabetes
Rozita Razavi et al.
CELL (2006)
Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane
Alexander T. Stein et al.
JOURNAL OF GENERAL PHYSIOLOGY (2006)
The TRPV1 receptor and nociception
David C. Immke et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2006)
Expression of capsaicin receptor immunoreactivity in human peripheral nervous system and in painful neuropathies
Giuseppe Lauria et al.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2006)
Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development
HK Rami et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)
Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain
AJ Culshaw et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Relative roles of protein kinase A and protein kinase C in modulation of transient receptor potential vanilloid type 1 receptor responsiveness in rat sensory neurons in vitro and peripheral nociceptors in vivo
A. Varga et al.
NEUROSCIENCE (2006)
Immunohistochemical co-localization of transient receptor potential vanilloid (TRPV)1 and sensory neuropeptides in the guinea-pig respiratory system
N. Watanabe et al.
NEUROSCIENCE (2006)
Attenuation of acid induced oesophagitis in VR-1 deficient mice
K Fujino et al.
GUT (2006)
NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels
XM Zhang et al.
EMBO JOURNAL (2005)
Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis
J Fernihough et al.
NEUROSCIENCE LETTERS (2005)
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice
K Bölcskei et al.
PAIN (2005)
Involvement of transient receptor potential vanilloid 1 in the vascular and hyperalgesic components of joint inflammation
J Keeble et al.
ARTHRITIS AND RHEUMATISM (2005)
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism
HX Xu et al.
JOURNAL OF NEUROSCIENCE (2005)
5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro
I Shimizu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats
P Honore et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid
R El Kouhen et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Functional recovery from desensitization of vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol 4,5-bisphosphate
BY Liu et al.
JOURNAL OF NEUROSCIENCE (2005)
Regulation of Ca2+-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase
DP Mohapatra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties
NR Gavva et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist
DM Swanson et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain
JR Ghilardi et al.
JOURNAL OF NEUROSCIENCE (2005)
A proinflarnmatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1
N Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: Structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties
A Gomtsyan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
SS Hong et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Inflammatory mediators convert anandamide into a potent activator of the vanilloid type 1 transient receptor potential receptor in nociceptive primary sensory neurons
AS Tahim et al.
NEUROSCIENCE (2005)
Phosphorylation of vanilloid receptor 1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid binding
JY Jung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
N-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists:: analysis of structure-activity relationships for the 'C-Region'
JW Lee et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2004)
[3H]resiniferatoxin autoradiography in the CNS of wild-type and TRPV1 null mice defines TRPV1 (VR-1) protein distribution
JC Roberts et al.
BRAIN RESEARCH (2004)
TRPV1 and the gut: from a tasty receptor for a painful vanilloid to a key player in hyperalgesia
P Holzer
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet β cells modulates insulin secretion in rats
Y Akiba et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Modulation of TRPV1 by nonreceptor tyrosine kinase, c-Src kinase
XC Jin et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2004)
Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors
SA Golech et al.
MOLECULAR BRAIN RESEARCH (2004)
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses
CJ Woodbury et al.
JOURNAL OF NEUROSCIENCE (2004)
Forty years in capsaicin research for sensory pharmacology and physiology
J Szolcsányi
NEUROPEPTIDES (2004)
Protease-activated receptors: protease signaling in the gastrointestinal tract
S Amadesi et al.
CURRENT OPINION IN PHARMACOLOGY (2004)
Synthesis and evaluation of pyridazinylpiperazines as vanilloid receptor 1 antagonists
L Tafesse et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity
C Morenilla-Palao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Molecular determinants of vanilloid sensitivity in TRPV1
NR Gavva et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels
S Mandadi et al.
CELL CALCIUM (2004)
Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages
CW Chen et al.
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
G Bhave et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues:: Novel potent and high affinity antagonists and partial antagonists of the vanilloid receptor
J Lee et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of Corti
JF Zheng et al.
JOURNAL OF NEUROPHYSIOLOGY (2003)
N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl) tetrahydropyrazine-1(2H)-carbox-amide(BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties:: I.: In vitro characterization and pharmacokinetic properties
KJ Valenzano et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Capsaicinoids cause inflammation and epithelial cell death through activation of vanilloid receptors
CA Reilly et al.
TOXICOLOGICAL SCIENCES (2003)
Expression profile of the transient receptor potential (TRP) family in neutrophil granulocytes:: evidence for currents through long TRP channel 2 induced by ADP-ribose and NAD
I Heiner et al.
BIOCHEMICAL JOURNAL (2003)
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia
CJ Chu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Selective increase of tumour necrosis factor-alpha in injured and spared myelinated primary afferents after chronic constrictive injury of rat sciatic nerve
M Schäfers et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
The VR1 antagonist capsazepine reverses mechanical hyperalgesia in models of inflammatory and neuropathic pain
KM Walker et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Activation of epidermal vanilloid receptor-1 induces release of proinflammatory mediators in human keratinocytes
MD Southall et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Anandamide and vanilloid TRPV1 receptors
RA Ross
BRITISH JOURNAL OF PHARMACOLOGY (2003)
Voltage-dependent priming of rat vanilloid receptor: effects of agonist and protein kinase C activation
GP Ahern et al.
JOURNAL OF PHYSIOLOGY-LONDON (2002)
p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
RR Ji et al.
NEURON (2002)
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
LA Birder et al.
NATURE NEUROSCIENCE (2002)
Cloning and functional characterization of the guinea pig vanilloid receptor 1
J Savidge et al.
NEUROPHARMACOLOGY (2002)
VR1, but not P2X3, increases in the spared L4 DRG in rats with L5 spinal nerve ligation
T Fukuoka et al.
PAIN (2002)
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
SM Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Direct phosphorylation of capsaicin receptor VR1 by protein Kinase Cε and identification of two target serine residues
M Numazaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Vanilloid receptor 1 expression in the rat urinary tract
A Avelino et al.
NEUROSCIENCE (2002)
Administration of capsiate, a non-pungent capsaicin analog, promotes energy metabolism and suppresses body fat accumulation in mice
K Ohnuki et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2001)
Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells
LA Birder et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Distinct potassium channels on pain-sensing neurons
MN Rasband et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
V Vellani et al.
JOURNAL OF PHYSIOLOGY-LONDON (2001)
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
HH Chuang et al.
NATURE (2001)
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia
M Tominaga et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
LJ Hudson et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
The vanilloid receptor (VR1)-mediated effects of anandamide are potently enhanced by the cAMP-dependent protein kinase
L De Petrocellis et al.
JOURNAL OF NEUROCHEMISTRY (2001)
Ligand-induced dynamic membrane changes and cell deletion conferred by vanilloid receptor 1
Z Olah et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Induction of vanilloid receptor channel activity by protein kinase C
LS Premkumar et al.
NATURE (2000)
Cloning and functional expression of a human orthologue of rat vanilloid receptor-1
P Hayes et al.
PAIN (2000)
Acid potentiation of the capsaicin receptor determined by a key extracellular site
SE Jordt et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
SW Hwang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
JB Davis et al.
NATURE (2000)
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
MJ Caterina et al.
SCIENCE (2000)
The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
D Smart et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
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