Synthesis of Difluoromethylated Alkenes via Copper-Catalyzed Protodefluorination of ss-(Trifluoromethyl)styrenes

Under typical copper-catalyzed hydroboration conditions, ss(trifluoromethyl)styrenes demonstrate unusal reactivities by forming difluoromethylated alkenes via a net protodefluorina- tion process. This is also distinct from trifluoromethyl alkenes with alkyl substituents where defluoroborylation products predominate.

Automated summary

Under typical copper-catalyzed hydroboration conditions, ss(trifluoromethyl)styrenes undergo protodefluorination to form difluoromethylated alkenes, which is distinct from trifluoromethyl alkenes with alkyl substituents that predominantly give defluoroborylation products.