Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.202300714
Keywords
Boron; Indole; Indoline; Hydroboration; Lewis acid-base pair
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A metal-free and sustainable method has been developed for the reduction of unprotected indoles. The catalytic system, consisting of B(C6F5)3 and THF as a Lewis acid-base pair, can activate the B-H bond of pincolborane. The catalytic system shows a broad substrate scope. Control experiments were conducted to understand the possible catalytic intermediates involved.
A sustainable and metal-free protocol has been described for the reduction of unprotected indoles. The catalytic system consists of B(C6F5)3 and THF as a Lewis acid-base pair that can activate the B-H bond of pincolborane (HBpin). The catalytic system encompasses a broad substrate scope. Control experiments were conducted to understand the possible catalytic intermediates involved during the present protocol. Metal-free reduction: A sustainable and cost-effective protocol has been developed for the hydroboration of unprotected indoles. The present catalytic system contains B(C6F5)3 and THF as a Lewis pair, which can activate the B-H bond of pincolborane followed by hydroboration of unprotected indoles.image
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