Journal
MEDICINAL CHEMISTRY RESEARCH
Volume 25, Issue 11, Pages 2680-2690Publisher
SPRINGER BIRKHAUSER
DOI: 10.1007/s00044-016-1629-4
Keywords
Phthalazine; 1,2,3, Triazole; Click chemistry; Antimicrobial activity; Antioxidant activity
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A new series of phthalazine-based 1,2,3-triazole derivatives (5a-h, 6a-f and 7a-d) were synthesized from the corresponding 2-(4-methyl/chloro benzyloxy) benzoic acid by multi-step reactions. Synthesized compounds were characterized by spectral studies and C, H, N analysis. The final compounds were screened for their antimicrobial, antifungal and antioxidant activity. Among them compounds 5c, 5g, 5h, 6b and 6e showed good antibacterial activity as compared to the standard drug streptomycin,whereas compounds 5g and 6d showed good antifungal activity comparable to the standard drug Fluconazole. Compounds 5a, 5f and 7c showed significant antioxidant property when compared with the standard butylated hydroxytoluene.
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