☆ 4.7 Article

CDK2 and CDK4 targeted liensinine inhibits the growth of bladder cancer T24 cells

CHEMICO-BIOLOGICAL INTERACTIONS (2023)

Related references

Note: Only part of the references are listed.

Article Cell Biology

DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer

Yan Li et al.

Summary: This study found that 7-dehydrocholesterol reductase (DHCR7) is upregulated in bladder cancer (BCa) and is associated with tumor grade and stage, resulting in poor prognosis. Further investigation revealed that DHCR7 overexpression promotes tumor cell proliferation, inhibits apoptosis, enhances invasion and migration, and induces epithelial-mesenchymal transition (EMT) through the PI3K/AKT/mTOR signaling pathway in vitro and in vivo. DHCR7 deficiency significantly decreases tumorigenesis. These findings suggest that DHCR7 may serve as a potential molecular target for the diagnosis and treatment of BCa.

CELLULAR SIGNALLING (2023)

Add to Collection

Article Oncology

microRNA-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer by targeting SMARCD1

Motoki Tamai et al.

Summary: MiR-99a-5p induces cellular senescence in gemcitabine-resistant bladder cancer cells by targeting SMARCD1, thereby inhibiting cell growth and restoring sensitivity to gemcitabine.

MOLECULAR ONCOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Therapeutic target database update 2022: facilitating drug discovery with enriched comparative data of targeted agents

Ying Zhou et al.

Summary: Drug discovery relies not only on knowledge of drugs and targets, but also on understanding comparative agents and targets. This study introduces a major update to the Therapeutic Target Database, providing valuable data on poor binders, non-binders, prodrug-drug pairs, co-targets, and drug-like properties, as well as additional features for advanced search and cross-links to target structures. The database is accessible without login requirement at: https://idrblab.org/ttd/.

NUCLEIC ACIDS RESEARCH (2022)

Add to Collection

Article Cell Biology

Liensinine Inhibits Osteosarcoma Growth by ROS-Mediated Suppression of the JAK2/STAT3 Signaling Pathway

Fei Jia et al.

Summary: The study found that liensinine can inhibit the growth of osteosarcoma and induce cell apoptosis. Liensinine exerts its anti-tumor activity by increasing intracellular reactive oxygen species production, altering the glutathione/glutathione disulfide ratio, and inducing mitochondrial membrane potential loss. Furthermore, liensinine can suppress the activation of the JAK2/STAT3 pathway to inhibit the growth of osteosarcoma.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2022)

Add to Collection

Review Pharmacology & Pharmacy

Network pharmacology: curing causal mechanisms instead of treating symptoms

Cristian Nogales et al.

Summary: For complex diseases, the traditional approach of drug discovery is highly ineffective. The shift towards systems and network medicine, along with the use of network pharmacology, revolutionizes the way we define, diagnose, and treat diseases. This approach focuses on causal, multitarget signaling modules, allowing for precise and effective therapeutic intervention through drug repurposing.

TRENDS IN PHARMACOLOGICAL SCIENCES (2022)

Add to Collection

Article Immunology

Liensinine alleviates high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) through suppressing oxidative stress and inflammation via regulating TAK1/AMPK signaling

Liping Liang et al.

Summary: This study explores the regulatory effects of liensinine (LIEN) on the progression of nonalcoholic fatty liver disease (NAFLD). The results show that LIEN can improve fatty liver by activating AMPK, reducing ROS production, and inhibiting inflammation. These findings suggest that LIEN could be a promising therapeutic strategy for NAFLD.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

Add to Collection

Article Oncology

TEAD4 functions as a prognostic biomarker and triggers EMT via PI3K/AKT pathway in bladder cancer

Ming Chi et al.

Summary: This study identified BLCA-related genes and found that TEAD4 plays an important role in EMT dysregulation. Overexpression of TEAD4 is associated with poor prognosis, invasion, and metastasis of BLCA, mediated through the regulation of the PI3K/AKT pathway. Therefore, TEAD4 is not only an effective biomarker for predicting prognosis but also a potential target for the treatment of metastatic BLCA.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Add to Collection

Review Pharmacology & Pharmacy

Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases

Erika Plazas et al.

Summary: Complex diseases such as neurodegenerative disorders and cancer pose a significant public health problem. The traditional pharmacotherapy based on a single target has been insufficient, and the emerging multi-target approach shows promise in the search for new drug candidates. Plant-derived isoquinoline alkaloids offer a vast source of multimodal agents with unique structural diversity and a wide range of pharmacological activities. This review provides a comprehensive compilation of the pharmacological relevance and multi-target potential of natural isoquinolines, emphasizing their promising activity in complex diseases.

PHARMACOLOGICAL RESEARCH (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

Bupivacaine modulates the apoptosis and ferroptosis in bladder cancer via phosphatidylinositol 3-kinase (PI3K)/AKT pathway

Jianli Hao et al.

Summary: This study aimed to investigate the effects of local anesthetic bupivacaine on bladder cancer cells. The results showed that bupivacaine inhibited cell activity, promoted apoptosis, and affected mitochondrial membrane potential, oxidative stress, and the PI3K/Akt signaling pathway in bladder cancer cells.

BIOENGINEERED (2022)

Add to Collection

Article Oncology

Cancer treatment and survivorship statistics, 2022

Kimberly D. Miller et al.

Summary: The number of cancer survivors in the United States is increasing due to population growth, aging, and improved detection and treatment. The most prevalent cancers are prostate, skin melanoma, and colon and rectum for males, and breast, uterine corpus, and thyroid for females. Treatment disparities exist, with Black patients being less likely to be diagnosed with early-stage cancer and having lower surgical receipt rates.

CA-A CANCER JOURNAL FOR CLINICIANS (2022)

Add to Collection

Review Medicine, General & Internal

Current best practice for bladder cancer: a narrative review of diagnostics and treatments

Eva Comperat et al.

Summary: This Seminar presents the current best practice for the diagnosis and management of bladder cancer, including challenges in pathology, advances in personalised medicine, and novel imaging approaches. It discusses the role of radiotherapy, surgical management, treatment of metastatic bladder cancer, and latest developments in systemic therapy.

LANCET (2022)

Add to Collection

Article Multidisciplinary Sciences

Indisulam synergizes with palbociclib to induce senescence through inhibition of CDK2 kinase activity

Ziva Pogacar et al.

Summary: This study found that the use of the CDK2 inhibitor, indisulam, can enhance the induction of senescence in cancer cells by the CDK4/6 inhibitor, palbociclib, and sensitize the cells to senolytic therapy.

PLOS ONE (2022)

Add to Collection

Review Oncology

Epidemiology, Screening, and Prevention of Bladder Cancer

Niyati Lobo et al.

Summary: Bladder cancer is the tenth most common cancer worldwide, with a higher incidence in men than women. Tobacco smoking is the primary risk factor, accounting for approximately 50% of cases. Routine screening is not recommended, but targeted screening for high-risk individuals may reduce mortality. Smoking cessation is the most important prevention measure.

EUROPEAN UROLOGY ONCOLOGY (2022)

Add to Collection

Article Environmental Sciences

Arsenic-induced HER2 promotes proliferation, migration and angiogenesis of bladder epithelial cells via activation of multiple signaling pathways in vitro and in vivo

Qing Zhou et al.

Summary: Arsenic is a known human carcinogen, and its oncogenic effects on bladder epithelial cells are mediated by activating HER2 and related signaling pathways.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

The DisGeNET cytoscape app: Exploring and visualizing disease genomics data

Janet Pinero et al.

Summary: The unbiased exploration of genomic variants has revealed hundreds of thousands of disease-associated loci, while network-based approaches are essential for understanding the molecular mechanisms underlying human diseases. The DisGeNET Cytoscape App integrates Cytoscape and DisGeNET functionalities to support various queries and analyses, offering a convenient tool for analyzing disease-related gene and variant networks.

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL (2021)

Add to Collection

Review Oncology

Advances in bladder cancer biology and therapy

Linda Tran et al.

Summary: Recent developments in bladder cancer research have focused on identifying mutated genes, understanding cellular aspects, and advancing non-invasive diagnostic methods. Immune checkpoint inhibitor therapeutics have shown significant therapeutic impact, providing patients with better monitoring options and hope for prolonged survival.

NATURE REVIEWS CANCER (2021)

Add to Collection

Article Pharmacology & Pharmacy

Mitophagy inhibitor liensinine suppresses doxorubicin-induced cardiotoxicity through inhibition of Drp1-mediated maladaptive mitochondrial fission

Xinyue Liang et al.

PHARMACOLOGICAL RESEARCH (2020)

Add to Collection

Article Oncology

Pterostilbene Sensitizes Cisplatin-Resistant Human Bladder Cancer Cells with Oncogenic HRAS

Yi-Ting Chen et al.

CANCERS (2020)

Add to Collection

Article Oncology

Combined CDK2 and CDK4/6 Inhibition Overcomes Palbociclib Resistance in Breast Cancer by Enhancing Senescence

Kamal Pandey et al.

CANCERS (2020)

Add to Collection

Article Oncology

Metformin targets a YAP1-TEAD4 complex via AMPKα to regulate CCNE1/2 in bladder cancer cells

Yanju Wu et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2019)

Add to Collection

Article Food Science & Technology

Neferine and isoliensinine enhance 'intracellular uptake of cisplatin' and induce 'ROS-mediated apoptosis' in colorectal cancer cells - A comparative study

Prasath Manogaran et al.

FOOD AND CHEMICAL TOXICOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

OMIM.org: leveraging knowledge across phenotype-gene relationships

Joanna S. Amberger et al.

NUCLEIC ACIDS RESEARCH (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Liensinine induces gallbladder cancer apoptosis and G2/M arrest by inhibiting ZFX-induced PI3K/AKT pathway

Yitong Shen et al.

ACTA BIOCHIMICA ET BIOPHYSICA SINICA (2019)

Add to Collection

Article Oncology

Liensinine inhibited gastric cancer cell growth through ROS generation and the PI3K/AKT pathway

Jia-hua Yang et al.

JOURNAL OF CANCER (2019)

Add to Collection

Article Oncology

Dual Inhibition of CDK4 and CDK2 via Targeting p27 Tyrosine Phosphorylation Induces a Potent and Durable Response in Breast Cancer Cells

Priyank Patel et al.

MOLECULAR CANCER RESEARCH (2018)

Add to Collection

Article Oncology

Integrated proteomic and phosphoproteomic analyses of cisplatin-sensitive and resistant bladder cancer cells reveal CDK2 network as a key therapeutic target

Jae Hun Jung et al.

CANCER LETTERS (2018)

Add to Collection

Article Cell Biology

MicroRNA-3619-5p suppresses bladder carcinoma progression by directly targeting β-catenin and CDK2 and activating p21

Qingsong Zhang et al.

CELL DEATH & DISEASE (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways

Sherif Abdelaziz Ibrahim et al.

MOLECULAR CANCER (2017)

Add to Collection

Article Biochemistry & Molecular Biology

MicroRNA-608 inhibits proliferation of bladder cancer via AKT/FOXO3a signaling pathway

Zhen Liang et al.

MOLECULAR CANCER (2017)

Add to Collection

Article Cell Biology

Shifting p53-induced senescence to cell death by TIS21/BTG2/Pc3 gene through posttranslational modification of p53 protein

Ok Ran Choi et al.

CELLULAR SIGNALLING (2016)

Add to Collection

Review Oncology

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

Prasad R. Dandawate et al.

SEMINARS IN CANCER BIOLOGY (2016)

Add to Collection

Review Oncology

Emerging role of checkpoint inhibition in localized bladder cancer

Parminder Singh et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2016)

Add to Collection

Article Cell Biology

A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission

Jing Zhou et al.

AUTOPHAGY (2015)

Add to Collection

Editorial Material Biochemical Research Methods

The potential clinical impact of the tissue-based map of the human proteome

Cecilia Lindskog

EXPERT REVIEW OF PROTEOMICS (2015)

Add to Collection

Article Urology & Nephrology

EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2013

Marko Babjuk et al.

EUROPEAN UROLOGY (2013)

Add to Collection

Article Chemistry, Applied

Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells

Paramasivan Poornima et al.

FOOD CHEMISTRY (2013)

Add to Collection

Article Multidisciplinary Sciences

Combining Machine Learning Systems and Multiple Docking Simulation Packages to Improve Docking Prediction Reliability for Network Pharmacology

Kun-Yi Hsin et al.

PLOS ONE (2013)

Add to Collection

Article Chemistry, Analytical

Semi-preparative high-speed counter-current chromatography separation of alkaloids from embryo of the seed of Nelumbo nucifera Gaertn by pH-gradient elution

Qingping Duanmu et al.

JOURNAL OF SEPARATION SCIENCE (2010)

Add to Collection

Review Urology & Nephrology

Recurrence and Progression of Disease in Non-Muscle-Invasive Bladder Cancer: From Epidemiology to Treatment Strategy

Bas W. G. van Rhijn et al.

EUROPEAN UROLOGY (2009)

Add to Collection

© Peeref 2019-2024. All rights reserved.