☆ 4.8 Review

Aptamer-Protein Interactions: From Regulation to Biomolecular Detection

CHEMICAL REVIEWS (2023)

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Summary: The selection stringency, specifically the target concentration, affects the outcome of SELEX. Excessively high target concentrations promote enrichment of low-affinity binders and suppress the enrichment of high-affinity aptamers. Understanding these principles is crucial for obtaining high-quality aptamers.

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A Chemiluminescence Sensor for the Detection of ?-Fetoprotein and Carcinoembryonic Antigen Based on Dual-Aptamer Functionalized Magnetic Silicon Composite

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Selective light-up of dimeric G-quadruplex forming aptamers for efficient VEGF165 detection

Ettore Napolitano et al.

Summary: In order to develop efficient anticancer theranostic systems, the interaction between a cyanine dye (CyOH) and two G-quadruplex-forming aptamers (V7t1 and 3R02) was studied. These aptamers recognized the Vascular Endothelial Growth Factor 165 (VEGF165), which is overexpressed in cancer cells and responsible for the rapid growth and metastases of solid tumors. Biophysical techniques, such as gel electrophoresis, circular dichroism (CD), UV-vis spectroscopy and fluorescence spectroscopy, were used to demonstrate that the cyanine interacted with both aptamers, giving a fluorescence light-up when bound to their dimeric forms. The dimeric G-quadruplexes of the aptamers showed higher affinity for VEGF165 and the fluorescence light-up was maintained when the dimeric aptamer-CyOH complexes bound to the target protein. These complexes, tested on MCF-7 cancer cells with non-tumorigenic MCF-10A cells as control, were effectively internalized in cells and colocalized with a fluorescently-labeled anti-VEGF-A antibody, enabling recognition and detection of the target. The studied systems are promising tools for anticancer theranostic strategies, combining the therapeutic potential of the G4-forming anti-VEGF aptamers with the diagnostic efficacy of the cyanine selective fluorescence light-up.

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Summary: Nucleic acid aptamers are single-stranded DNA or RNA fragments that can specifically recognize targets. However, natural aptamers composed of 4 naturally occurring nucleosides often have inferior binding affinity compared to antibodies. To address this, various high-affinity modification strategies have been developed, such as nucleobase modifications, fluorine modifications, structural alteration modifications, phosphate modifications, and extended alphabets. These modifications enhance the non-covalent bonding between the modified aptamers and target proteins, resulting in significantly improved affinity. This review provides an overview of these high-affinity modification strategies and their effects on the pharmacodynamic properties of aptamers.

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In Silico Approaches for the Identification of Aptamer Binding Interactions to Leptospira spp. Cell Surface Proteins

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Directed Evolution of Aptamer Discovery Technologies

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A label-free colorimetric aptasensor based on split aptamers-chitosan oligosaccharide-AuNPs nanocomposites for sensitive and selective detection of kanamycin

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Electron transfer-triggered imaging of EGFR signaling activity

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Non-immobilized GO-SELEX of aptamers for label-free detection of thiamethoxam in vegetables

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Aptamer-Based Analysis and Manipulation of the Protein Activity in Living Cells

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Systematically Modulating Aptamer Affinity and Specificity by Guanosine-to-Inosine Substitution

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Potentiometric aptasensing of Escherichia coli based on electrogenerated chemiluminescence as a highly sensitive readout

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Aptamer Targets Triple-Negative Breast Cancer through Specific Binding to Surface CD49c

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Iron-Containing Protein-Mimic Supramolecular Iron Delivery Systems for Ferroptosis Tumor Therapy

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High Mannose-Specific Aptamers for Broad-Spectrum Virus Inhibition and Cancer Targeting

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Ultrasensitive FRET-based aptasensor for interleukin-6 as a biomarker for COVID-19 progression using nitrogen-doped carbon quantum dots and gold nanoparticles

Mohamad Mahani et al.

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Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

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Progress in DNA Aptamers as Recognition Components for Protein Functional Regulation

Hu Lingling et al.

Summary: Proteins are essential in all life domains and precise regulation of their activity is crucial for understanding biological processes and therapeutic applications. Nucleic acid aptamers obtained through SELEX have specific protein recognition characteristics similar to antibodies and can help regulate their activity. This minireview covers the selection of protein-binding aptamers using SELEX, membrane protein analysis techniques based on aptamer-mediated target recognition, aptamer-mediated functional regulation of proteins (including membrane receptors and non-membrane proteins such as thrombin), as well as the potential challenges and prospects of aptamer-mediated protein manipulation, providing useful information for researchers in this field.

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES (2022)

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Aptamer truncation strategy assisted by molecular docking and sensitive detection of T-2 toxin using SYBR Green I as a signal amplifier

Pengfei Ma et al.

Summary: A novel truncation strategy for aptamers' sequences based on molecular docking was reported for the first time. The truncated aptamers showed increased affinity and were successfully applied in rapid fluorescence detection of T-2 toxin.

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Selective isolation and sensitive detection of lysozyme using aptamer based magnetic adsorbent and a new quartz crystal microbalance system

Gulay Bayramoglu et al.

Summary: In this study, magnetic chitosan beads and quartz crystal microbalance chip were decorated with lysozyme specific aptamer for efficient isolation and detection of lysozyme. The developed sensor system enables label-free, concentration-dependent, and selective detection of lysozyme with high sensitivity.

FOOD CHEMISTRY (2022)

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Discovery of a Transferrin Receptor 1-Binding Aptamer and Its Application in Cancer Cell Depletion for Adoptive T-Cell Therapy Manufacturing

Emmeline L. Cheng et al.

Summary: This study reports the identification of a novel high-affinity DNA aptamer, tJBA8.1, that binds transferrin receptor 1 (TfR1). The aptamer was found to effectively deplete B lymphoma cells from peripheral blood mononuclear cells with minimal impact on the composition of healthy immune cells. This research provides a facile, universal, and inexpensive approach for safe manufacturing of adoptive T-cell therapies.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

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Article Nanoscience & Nanotechnology

Structure-switchable aptamer-arranged reconfigurable DNA nanonetworks for targeted cancer therapy

Zhenmeng Wang et al.

Summary: Structural DNA nanotechnology has great potential in applications such as bioimaging, drug delivery, and cancer therapy. This study demonstrates an intelligent aptamer-incorporated DNA nanonetwork for cancer cell imaging and targeted drug delivery. The nanonetwork can transform into nanosheet intermediates and specifically enter target cells through cancer cell-surface receptors, showing increased binding affinity and maintaining structural integrity.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2022)

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Advances in aptameric biosensors designed to detect toxic contaminants from food, water, human fluids, and the environment

Ulhas Sopanrao Kadam et al.

Summary: This article provides an update on the advances of nucleic acid-based aptameric sensors for molecular diagnostics of toxic chemicals from food, water, human fluids, and the environment.

TRENDS IN ENVIRONMENTAL ANALYTICAL CHEMISTRY (2022)

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Electroactive nanocarbon materials as signaling tags for electrochemical PCR

Rachel Rui Xia Lim et al.

Summary: Electrochemical polymerase chain reaction (PCR) is a valid alternative to optical-based PCR, with advantages such as reduced costs, simpler instrumentation, and miniaturization and portability of systems. This study compared three different nanographene oxide materials as signaling tags for the detection of genetically modified organisms (GMO) and identified the nanocarbon material with the highest potential for use as an electroactive label in PCR amplification and detection.

TALANTA (2022)

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Article Food Science & Technology

Selection and Characterization of DNA Aptamers for Constructing Aptamer-AuNPs Colorimetric Method for Detection of AFM1

Ruobing Liu et al.

Summary: An ssDNA aptamer (Apt-5) with high affinity and specificity for AFM1 was successfully isolated and used to detect AFM1 in milk and dairy products.

FOODS (2022)

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Aptamer-Gold Nanocage Composite for Photoactivated Immunotherapy

Wen Song et al.

Summary: Researchers have developed a photoactivated immunotherapy nanoplatform that can target tumor tissues and release immune-activating substances, leading to precise immunotherapy and effective cancer treatment.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Biomimetic synthesis of protein-DNA-CaHPO4 hybrid nanosheets for biosensing: Detection of thrombin as an example

Ranfeng Ye et al.

Summary: This study introduces a new biomimetic synthesis strategy to efficiently synthesize a novel biomolecule-inorganic hybrid nanosheet without the need for additional modifications at room temperature. This method avoids the complex and time-consuming process of coupling proteins with DNA, showing great potential for wide applications.

ANALYTICA CHIMICA ACTA (2022)

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Article Chemistry, Multidisciplinary

Programmable Assembly of Multivalent DNA-Protein Superstructures for Tumor Imaging and Targeted Therapy

Zhen Xu et al.

Summary: In this study, programmable DNA-protein superstructures were successfully assembled through biomimetic assembly, by combining programmable polymer DNA wire with alkaline protein protamine to form densely packed DNA nanospheres. These DNA-protein superstructures exhibited specifically high affinity and stability, enabling high cancer cell selectivity and reduced side effects.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biophysics

An ultrasensitive dual-signal aptasensor based on functionalized Sb@ZIF-67 nanocomposites for simultaneously detect multiple biomarkers

Ya Zhang et al.

Summary: This paper presents an enzyme-free and label-free dual-signal aptasensor for simultaneous detection of multiple tumor biomarkers. By adsorbing the aptamer chains on quantum dots and utilizing electrochemical and fluorescent signals, accurate detection of HER2 and ER from tissue to serum is achieved.

BIOSENSORS & BIOELECTRONICS (2022)

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Review Chemistry, Multidisciplinary

Influence of Sugar Modifications on the Nucleoside Conformation and Oligonucleotide Stability: A Critical Review

Gourav Das et al.

Summary: The conformation of ribofuranose sugar is crucial for the structure and dynamics of functional nucleic acids. Different chemical modifications have been introduced to enhance their therapeutic potential and physicochemical properties. This review systematically categorizes the various ribofuranose sugar modifications used in DNAs and RNAs and discusses their effects on sugar puckering.

CHEMICAL RECORD (2022)

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Article Chemistry, Analytical

Ratiometric fluorescent detection of pesticide based on split aptamer and magnetic separation

Ying Wang et al.

Summary: Pesticide residues pose a serious threat to human health and the sustainable development of the environment. The establishment of an efficient detection platform for pesticides is crucial. Researchers have successfully developed a novel ratiometric fluorescent aptasensor for the sensitive determination of pesticides. This sensor offers a label-free and enzyme-free detection of isocarbophos (ICP) with high sensitivity and specificity, providing new ways for pesticide assays in agricultural products or environmental samples.

SENSORS AND ACTUATORS B-CHEMICAL (2022)

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Article Multidisciplinary Sciences

Functional selectivity of insulin receptor revealed by aptamer-trapped receptor structures

Junhong Kim et al.

Summary: Here, the authors determine the structures of insulin receptor bound to aptamers and provide a basis for the selective activation or allosteric regulation of the insulin receptor.

NATURE COMMUNICATIONS (2022)

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Article Nanoscience & Nanotechnology

DNA aptamer selection and construction of an aptasensor based on graphene FETs for Zika virus NS1 protein detection

Nathalie B. F. Almeida et al.

Summary: In this study, an aptamer (ZIKV60) with high affinity and specificity to Zika virus NS1 protein was selected through CE-SELEX. The ZIKV60 aptamer showed a strong binding affinity to ZIKV NS1, and exhibited high specificity compared to NS1 from DENV and YFV. The functionalized graphene field-effect transistor devices with ZIKV60 demonstrated the potential for differential diagnosis of Zika virus.

BEILSTEIN JOURNAL OF NANOTECHNOLOGY (2022)

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Article Chemistry, Analytical

Qiang Zhao -; ; ; ? orcid.org/0000-0003-3448-8756;

Hao Yu et al.

Summary: We demonstrated a strategy of constructing aptamer thermal switch for rapid and sensitive detection of targets, which can be used in various research fields such as environmental monitoring, food safety, and molecular diagnosis.

ANALYTICAL CHEMISTRY (2022)

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Article Chemistry, Analytical

In Situ Visualization of Epidermal Growth Factor Receptor Nuclear Translocation with Circular Bivalent Aptamer

Lei Zhang et al.

Summary: In this study, a highly stable probe was designed to visualize the nuclear translocation of EGFR in situ for a long term. The results demonstrated that the probe could monitor the entire nuclear translocation of EGFR and evaluate the development and progression of tumors.

ANALYTICAL CHEMISTRY (2022)

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Article Computer Science, Interdisciplinary Applications

Generative aptamer discovery using RaptGen

Natsuki Iwano et al.

Summary: This study developed a method called RaptGen for in silico aptamer generation. By embedding simulated sequence data into a low-dimensional latent space based on motif information, RaptGen successfully generated aptamers that were not included in high-throughput sequencing. The study demonstrated that RaptGen could be applied to activity-guided aptamer generation and that the latent representation played an important role in aptamer discovery.

NATURE COMPUTATIONAL SCIENCE (2022)

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Article Biochemistry & Molecular Biology

Characterization of the interaction of multivalent glycosylated ligands with bacterial lectins by biolayer interferometry

L. Picault et al.

Summary: This study used biolayer interferometry to monitor multivalent carbohydrate-protein interactions and prepared various glycoclusters and dendrimers as ligands. The results were in agreement with previous studies and the methods had lower requirements.

GLYCOBIOLOGY (2022)

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Article Biochemistry & Molecular Biology

Cryo-EM advances in RNA structure determination

Haiyun Ma et al.

Summary: Cryo-electron microscopy is an unprecedented tool for resolving protein structures at atomic resolution. It offers advantages in exploring biological samples inaccessible by conventional methods, especially in resolving conformational and compositional heterogeneity of large protein complexes. However, there are still challenges and limitations in using cryo-electron microscopy to study RNA structures.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2022)

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Review Chemistry, Multidisciplinary

Nucleic Acid Aptamers for Molecular Diagnostics and Therapeutics: Advances and Perspectives

Long Li et al.

Summary: SELEX technology has shown the ability to evolve artificial ligands with affinity and specificity, and aptamers complement antibodies with unique advantages such as small size, low cost, and facile chemical modification, making them a potential molecular tool for future clinical needs in biomedicine.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Biochemistry & Molecular Biology

Molecular dynamics simulations of human α-thrombin in different structural contexts: evidence for an aptamer-guided cooperation between the two exosites

Romualdo Troisi et al.

Summary: This study utilized molecular dynamics simulations to investigate the dynamic interactions of thrombin with aptamers TBA and HD22_27mer in binary/ternary complexes, revealing the mechanism of stabilization of these complexes in a crystal-free environment. The dynamics analysis indicated a communication between the exosites in different thrombin binding states, providing insights into the cooperativity of TBA/HD22_27mer binding experimentally detected.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2021)

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Review Nanoscience & Nanotechnology

Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications

Shuaijian Ni et al.

Summary: Aptamers, with oligonucleotide sequences, have capabilities to bind to specific target molecules and are attracting great attention in diverse clinical translations. They offer advantages such as prolonged storage life and feasibility of chemical modifications for enhancing stability.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Chemistry, Analytical

Investigation of the recognition interaction between glycated hemoglobin and its aptamer by using surface plasmon resonance

Dapeng Sun et al.

Summary: The study found that factors like pH and salt concentration of the solution can greatly affect the formation of a complex between aptamers and HbA1c. The loop L1 structure in the aptamer may be crucial for recognizing glycated hemoglobin, and the optimal detection condition was pH 6.

TALANTA (2021)

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Review Chemistry, Medicinal

Anti-VEGF DNA-based aptamers in cancer therapeutics and diagnostics

Claudia Riccardi et al.

Summary: The VEGF family and its receptors are crucial in pathological angiogenesis and cancer progression, leading to the development of potential treatments for malignant tumors. Various VEGF inhibitors, including small molecules, antibodies, and nucleic acid-based aptamers, have been evaluated for clinical use, showing promising therapeutic potential in anticancer strategies. Efforts to optimize these aptamers by increasing target affinity and exploring structural analogues of lead compounds have been made, highlighting their significance in highly selective biosensor construction and therapeutic applications.

MEDICINAL RESEARCH REVIEWS (2021)

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Review Chemistry, Analytical

The dynamicity of light-up aptamers in one-pot in vitro diagnostic assays

Marimuthu Citartan

Summary: Light-up aptamers are aptamers that trigger fluorescence emission of specific dyes upon binding, widely used in in vivo imaging and in vitro diagnostic assay development. This study aims to provide an overview of various diagnostic assay formats developed using light-up aptamers, offering insights for researchers interested in developing one-pot in vitro diagnostic assays based on light-up aptamers.

ANALYST (2021)

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Article Chemistry, Analytical

Evaluation the effect of nanoparticles on the structure of aptamers by analyzing the recognition dynamics of aptamer functionalized nanoparticles

Wenchao Jia et al.

Summary: This study focused on the role of aptamer-functionalized nanoparticles in biomedical applications, showing that the rigidity of nanoparticles can maintain the spatial structure of the aptamer, which plays a crucial role in influencing the interaction between nanoprobe and target receptors.

ANALYTICA CHIMICA ACTA (2021)

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Article Chemistry, Multidisciplinary

Specific Ion-Protein Interactions Influence Bacterial Ice Nucleation

Ralph Schwidetzky et al.

Summary: The efficiency of bacterial ice nucleators can be profoundly influenced by ions, with strongly hydrated ions facilitating ice nucleation while weakly hydrated ions inhibiting it. Specific ion-protein interactions on the surface of bacteria play a key role in heterogeneous ice nucleation, highlighting the importance of understanding the nature of ions in this process.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

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Article Medical Laboratory Technology

Association of hemoglobin H (HbH) disease with hemoglobin A1c and glycated albumin in diabetic and non-diabetic patients

Dabao He et al.

Summary: The study found that HbA1c levels were significantly lower in patients with HbH disease compared to healthy individuals, while GA showed no significant difference between the two groups. Using HbA1c as a diagnostic criterion for diabetes may lead to a considerable number of diabetic patients with HbH disease being missed. GA, instead of HbA1c, is suitable for monitoring glycemic control in patients with HbH disease and can modify HbA1c's discriminative ability for diagnosing diabetes.

CLINICAL CHEMISTRY AND LABORATORY MEDICINE (2021)

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Article Chemistry, Medicinal

Improving Thermodynamic Stability and Anticoagulant Activity of a Thrombin Binding Aptamer by Incorporation of 8-trifluoromethyl-2′-deoxyguanosine

Hong-Liang Bao et al.

Summary: In this study, the incorporation of 8-trifluoromethyl-2'-deoxyguanosine ((F)G) into a thrombin binding aptamer (TBA) significantly increased the melting temperature and anticoagulant activity of the TBA sequence, demonstrating that (F)G is a powerful nucleoside derivative.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Engineering, Biomedical

Silver-Coated Disordered Silicon Nanowires Provide Highly Sensitive Label-Free Glycated Albumin Detection through Molecular Trapping and Plasmonic Hotspot Formation

Debadrita Paria et al.

Summary: A label-free surface-enhanced Raman spectroscopy sensing platform utilizing silver-coated silicon nanowires has been developed to achieve highly sensitive and reproducible quantification of glycated albumin. This technology allows for visual detection of glycated albumin at levels as low as 500 x 10(-9) m, significantly below the physiological range.

ADVANCED HEALTHCARE MATERIALS (2021)

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Article Medicine, Research & Experimental

An aptamer interacting with heat shock protein 70 shows therapeutic effects and prognostic ability in serous ovarian cancer

Chang-Ni Lin et al.

Summary: Tx-01, a novel aptamer, shows specificity in recognizing ovarian cancer cells and tissues, inhibiting migration and invasion, and suppressing tumor growth through disrupting HSP70/NICD interaction. It acts as a prognostic factor and potential inhibitor in ovarian cancer treatment.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Medicine, Research & Experimental

Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12

Igor Smirnov et al.

Summary: The study investigates the enhancement of recognition interface between thrombin-binding aptamer HD1 (TBA) and thrombin by adding chemically modified side chains to selected nucleotide residues. The modified variants showed increased affinity and anticoagulant activity, with crystal structures revealing the importance of non-equivalent binding modes in determining affinity characteristics. This approach of extending the recognition surface between protein and modified aptamers holds promise for improving aptamer ligand characteristics.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Chemistry, Multidisciplinary

Impact of the Coverage of Aptamers on a Nanoparticle on the Binding Equilibrium and Kinetics between Aptamer and Protein

Xueqian Chen et al.

Summary: Understanding the impact of aptamer quantity on the interaction between aptamer and target protein is crucial in biosensor development; Aptamer coverage significantly affects both the thermodynamics and kinetics of binding; For biosensors, AuNPs-aptamer conjugate with the highest surface coverage is most favorable for detection limit, sensitivity, and response time.

ACS SENSORS (2021)

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Review Chemistry, Multidisciplinary

Advances and Challenges in Small-Molecule DNA Aptamer Isolation, Characterization, and Sensor Development

Haixiang Yu et al.

Summary: This review discusses the challenges and advances in isolating and characterizing small-molecule-binding DNA aptamers, including in vitro methodologies for isolation, strategies for optimal binding properties, techniques for characterizing aptamer-target binding and structure, and various small-molecule sensing platforms and detection applications based on aptamers.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Spherical Neutralizing Aptamer Inhibits SARS-CoV-2 Infection and Suppresses Mutational Escape

Miao Sun et al.

Summary: The study introduces a novel neutralizing agent SNAP, which demonstrates exceptional binding affinity and potent neutralization against SARS-CoV-2 through multivalent aptamer assembly and steric hindrance effect of the gold scaffold. Moreover, SNAP exhibits broad neutralizing activity, almost completely blocking the infection of three mutant pseudo viruses.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

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Review Chemistry, Multidisciplinary

Aptamer-Based Detection of Circulating Targets for Precision Medicine

Lingling Wu et al.

Summary: In the past decade, precision medicine has made continuous progress in improving human health. Liquid biopsy, as an emerging diagnostic technique, relies on the sensitive and reliable detection of circulating targets using aptamers as recognition ligands, offering real-time, comprehensive physiological and pathological information in a non-invasive manner. Aptamers, with their unique tertiary structures and superior specificity and affinity, are ideal recognition ligands for liquid biopsy, making them a promising tool for precision medicine.

CHEMICAL REVIEWS (2021)

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Article Biochemistry & Molecular Biology

Selection and Characterization of Vimentin-Binding Aptamer Motifs for Ovarian Cancer

Andrea M. Costello et al.

Summary: The application of aptamers in cancer research is gaining importance due to their high specificity and low immunogenicity. Vimentin, an intermediate filament protein overexpressed in cancerous endothelial cells, has been targeted using thioated aptamers with high specificity. Future applications include targeted imaging and therapy using vimentin binding aptamers.

MOLECULES (2021)

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Article Multidisciplinary Sciences

A serum-stable RNA aptamer specific for SARS-CoV-2 neutralizes viral entry

Julian Valero et al.

Summary: A special RNA aptamer with high affinity to the receptor binding domain of SARS-CoV-2 spike protein has been discovered, preventing its interaction with the host receptor and efficiently blocking viral infection. Trimerized version of the aptamer enhances binding affinity, showing potential for widespread use in detecting and treating SARS-CoV-2 and emerging variants.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Chemistry, Analytical

S1 nuclease digestion-based rational truncation of PD-L1 aptamer and establishment of a signal dual amplification aptasensor

Hongwei Hu et al.

Summary: Optimizing aptamer truncation can enhance specificity and robustness through rational design based on nuclease digestion, as demonstrated in the development of a highly sensitive fluorescence aptasensor for PD-L1 detection.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Multidisciplinary

Influence of Fluorinated Components on Perovskite Solar Cells Performance and Stability

Nabonswende Aida Nadege Ouedraogo et al.

Summary: The use of fluorinated compounds in perovskite solar cell devices can effectively improve device performance and long-term stability, thanks to the high electronegativity and strong hydrophobicity of the fluorine atom.

SMALL (2021)

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Review Chemistry, Analytical

Engineered aptamer for the analysis of cells

Xiaochen Tang et al.

Summary: Since the discovery of aptamers about 30 years ago, they have shown great potential for applications in biosensor construction and bioanalysis. However, limitations arise when dealing with more complex analytes, such as cells and living organisms, due to their excessive flexibility and high nuclease-sensitivity. Efforts have been made to develop novel engineered aptamers to expand their applications for living cell analysis, even in vivo tissues.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

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Article Multidisciplinary Sciences

Discovery of indole-modified aptamers for highly specific recognition of protein glycoforms

Alex M. Yoshikawa et al.

Summary: Glycosylation is a common post-translational modification with significant impact on biological processes and diseases. The authors present a generalizable workflow for selecting aptamers with indole-modified bases to recognize specific protein glycoforms. This approach allows for the identification of aptamers with strong selectivity for specific glycoforms and offers a promising strategy for glycobiology research.

NATURE COMMUNICATIONS (2021)

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Article Cell Biology

Prostate-Specific Membrane Antigen (PSMA) Promotes Angiogenesis of Glioblastoma Through Interacting With ITGB4 and Regulating NF-κB Signaling Pathway

Yang Gao et al.

Summary: This study found that high expression of PSMA in GBM is associated with poor prognosis, promoting angiogenesis in GBM by enhancing proliferation, invasion, and tube formation ability of HUVECs. PSMA may promote angiogenesis in GBM by interacting with ITGB4 and activating the NF-kappa B signaling pathway.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Biology

Recent Progress and Opportunities for Nucleic Acid Aptamers

Jonghoe Byun

Summary: Aptamers, short nucleic acid sequences capable of specific molecular binding, have shown significant potential in therapeutics and diagnostics. Despite challenges in clinical trials, novel technologies and advancements are fueling hope in the field of aptamers.

LIFE-BASEL (2021)

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Article Chemistry, Multidisciplinary

Kinetic Microscale Thermophoresis for Simultaneous Measurement of Binding Affinity and Kinetics

Julian A. C. Stein et al.

Summary: MST is a versatile technique for measuring binding affinities, based on directional movement of molecules in a temperature gradient. We extended MST to measure binding kinetics by increasing thermal dissipation, allowing for simultaneous determination of kinetics and binding affinity. By measuring DNA hybridization rates, we observed linear dependence of on-rates on salt concentration and weak dependence on strand length and temperature.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Biochemistry & Molecular Biology

Structural Biology for the Molecular Insight between Aptamers and Target Proteins

Ning Zhang et al.

Summary: Aptamers show promise as therapeutic and diagnostic agents for various diseases due to their high affinity and specificity. Structural studies and modification strategies are crucial for understanding and optimizing the interactions between aptamers and target proteins. Challenges in resolving aptamer-protein complex structures still exist, but advancements in methodologies could facilitate the development of aptamer-based therapeutics.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Chemistry, Analytical

Biomineralized Mn3(PO4)2/aptamer nanosheets for enhanced electrochemical determination of C-reactive protein

Xiaofeng Tan et al.

Summary: Bio-inspired enzyme-inorganic hybrid nanomaterials play a vital role in biological applications by enhancing enzyme activity and stability for signal generation. The coordination interaction between metal ions and amide groups in enzymes drives the evolution of various morphology and structure. By introducing the CRP aptamer as an organic part and utilizing the inorganic part for signal generation and transduction, the electrochemical aptasensor shows excellent detection performance for CRP.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Chemistry, Analytical

Aptamer-functionalized Au nanoparticles array as the effective SERS biosensor for label-free detection of interleukin-6 in serum

Muhammad Muhammad et al.

Summary: This study successfully developed a label-free biosensor for detecting interleukin-6 and achieved quantitative evaluation in a low concentration range. The research indicates that the aptamer-based SERS biosensor can be a promising tool for quick and convenient medical diagnosis applications.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Article Multidisciplinary Sciences

Machine learning guided aptamer refinement and discovery

Ali Bashir et al.

Summary: Aptamers are single-stranded nucleic acid ligands that bind target molecules with high affinity and specificity. Machine learning can help predict high-performing aptamers and expedite the discovery of better diagnostic and therapeutic agents.

NATURE COMMUNICATIONS (2021)

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Article Materials Science, Biomaterials

Systematic Approach to DNA Aptamer Design Using Amino Acid-Nucleic Acid Hybrids (ANHs) Targeting Thrombin

Ji Hye Yum et al.

Summary: Chemical modifications of innate DNA/RNA aptamers can improve their function. This study demonstrates a modular strategy to manipulate a thrombin-binding DNA aptamer by incorporating amino acid conjugates to enhance anticoagulation activity and binding affinity. The research findings reveal that substitutions with hydrophobic amino acids in the loop region can significantly increase antithrombin activity.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Article Chemistry, Multidisciplinary

High-Affinity Dimeric Aptamers Enable the Rapid Electrochemical Detection of Wild-Type and B.1.1.7 SARS-CoV-2 in Unprocessed Saliva

Zijie Zhang et al.

Summary: This study developed a simple and rapid saliva-based SARS-CoV-2 antigen test using a newly developed DNA aptamer, which showed high sensitivity and specificity in detecting the wildtype virus and its Alpha and Delta variants.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Discovery and Characterization of Spike N-Terminal Domain-Binding Aptamers for Rapid SARS-CoV-2 Detection

Nataly Kacherovsky et al.

Summary: The COVID-19 pandemic has caused devastation to families, healthcare, economies, and societies globally. Molecular recognition agents that bind to specific viral proteins are crucial for rapid diagnostics and targeted therapeutics. This work demonstrates the selection of novel DNA aptamers that bind to the SARS-CoV-2 spike glycoprotein with high specificity and affinity, making them promising tools for COVID-19 diagnostics.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Chemistry, Multidisciplinary

Self-Assembling Nucleic Acid Nanostructures Functionalized with Aptamers

Abhichart Krissanaprasit et al.

Summary: Researchers have made progress in understanding and manipulating the rules of biomolecular design for artificial biopolymer complexes. Nucleic acid nanotechnology has advanced rapidly, with DNA and RNA design seeing amazing progress. By combining structural motifs with aptamers, nucleic acid-based self-assemblies offer bioengineers a diverse toolbox for potential revolutionary biological activities.

CHEMICAL REVIEWS (2021)

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Article Electrochemistry

A multivalent aptamer-based electrochemical biosensor for biomarker detection in urinary tract infection

Maryam Naseri et al.

Summary: This study introduces a novel electrochemical aptasensor with a multivalent aptamer immobilized on the electrode surface for label-free detection of lactoferrin with high sensitivity and wide detection range. The biosensor shows excellent selectivity and reproducibility in buffer solution, and is successfully applied for quantifying lactoferrin concentrations in urine samples.

ELECTROCHIMICA ACTA (2021)

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Article Pharmacology & Pharmacy

Revisiting inorganic nanoparticles as promising therapeutic agents: A paradigm shift in oncological theranostics

Mohammad Afsar Khan et al.

Summary: Inorganic nanoparticles are considered promising agents in treating and tracing cancer due to their unique physicochemical properties, making them efficient particles in cancer theranostics. Promising inorganic-NPs include gold, selenium, silica, and oxide NPs, with surface modifications enhancing their effectiveness for transporting therapeutic cargos to overcome cellular barriers.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

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Article Chemistry, Applied

Phosphorylation of myosin regulatory light chain at Ser17 regulates actomyosin dissociation

Lichuang Cao et al.

Summary: The study reveals that the phosphorylation status of myosin regulatory light chain plays a crucial role in regulating actomyosin dissociation, by reducing kinetic and total energy, stabilizing structure, and facilitating interaction between myosin and actin.

FOOD CHEMISTRY (2021)

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Article Biochemistry & Molecular Biology

Mucoadhesive properties of nanogels based on stimuli-sensitive glycosaminoglycan-graft-pNIPAAm copolymers

Iuliia Pilipenko et al.

Summary: This study investigated two types of nanogels for improving ocular drug delivery, showing that cross-linked nanogels with disulfide linkages and thiol groups have enhanced mucoadhesive properties. In vivo intraocular pressure studies also demonstrated that polymers in solution can affect the ocular absorption of certain drugs, indicating the potential of these copolymers for ocular drug delivery applications.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

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Article Chemistry, Multidisciplinary

Construction of Aptamer-Based Molecular Beacons with Varied Blocked Structures and Targeted Detection of Thrombin

Zhiqing Zhang et al.

Summary: A blocked aptamer-functionalized molecular beacon (MB) was designed as fluorescence sensors to detect thrombins by binding-induced turn-on structural transformation. The length of the complementary cDNA greatly influenced the structure of MBs, with MB(8 + 8) and MB(15 + 8) forming quenching MBs. The quenching efficiency of MBs was found to increase with the molar ratio of SS and cDNA, with MB(8 + 8) and MB(15 + 8) showing detection limits of 0.19 and 1.2 nM for thrombin, respectively. Selectivity and recovery rates in diluted serum samples were also demonstrated.

LANGMUIR (2021)

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Article Biochemistry & Molecular Biology

Structural and Binding Effects of Chemical Modifications on Thrombin Binding Aptamer (TBA)

Vibhav Valsangkar et al.

Summary: Chemical modifications of the thrombin binding aptamer were studied for their effects on structure and thrombin binding affinity, with modifications found to maintain stability and binding patterns similar to the native form. Potential positions for modifications were identified without adverse effects, providing insights for the design and development of more functional TBA analogues.

MOLECULES (2021)

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Review Chemistry, Multidisciplinary

Aptamer functionalized nanomaterials for biomedical applications: Recent advances and new horizons

Mansour Mahmoudpour et al.

Summary: This review discusses the design and applications of aptamer functionalized nanomaterials (AFMs) in the biomedical field, including synthesis strategies, versatile roles of nanomaterials, and representative examples of biomedical applications. Challenges and opportunities in this emerging field are also presented.

NANO TODAY (2021)

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Article Multidisciplinary Sciences

Highly accurate protein structure prediction with AlphaFold

John Jumper et al.

Summary: Proteins are essential for life, and accurate prediction of their structures is a crucial research problem. Current experimental methods are time-consuming, highlighting the need for accurate computational approaches to address the gap in structural coverage. Despite recent progress, existing methods fall short of atomic accuracy in protein structure prediction.

NATURE (2021)

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Article Biochemistry & Molecular Biology

Diverse high-affinity DNA aptamers for wild-type and B.1.1.7 SARS-CoV-2 spike proteins from a pre-structured DNA library

Jiuxing Li et al.

Summary: In vitro selection experiments identified DNA aptamers, MSA1 and MSA5, with strong binding affinity to the S1 subunit of the SARS-CoV-2 spike protein. These aptamers demonstrated comparable affinities for various forms of S1 protein and also recognized the pseudotyped lentivirus of SARS-CoV-2, highlighting their potential as diagnostic tools for COVID-19 detection. The development of a colorimetric sandwich assay using MSA1 further confirmed the utility of these aptamers in detecting the virus in saliva samples.

NUCLEIC ACIDS RESEARCH (2021)

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Article Multidisciplinary Sciences

Predicting aptamer sequences that interact with target proteins using an aptamer-protein interaction classifier and a Monte Carlo tree search approach

Gwangho Lee et al.

Summary: An approach utilizing machine learning for selecting candidate aptamer sequences was proposed, allowing the generation of sequences of different sizes with high binding affinity for specific target proteins, without being limited to a specific size compared to traditional experimental methods. By applying the MCTS algorithm to generate candidate sequences, designing a tree structure for nucleotide sequence sampling, and evaluating the quality of the generated sequences through docking simulations, the method showed similar or better docking scores in ZDOCK docking simulations than known aptamers.

PLOS ONE (2021)

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Article Chemistry, Analytical

High-affinity aptamer of allergen β-lactoglobulin: Selection, recognition mechanism and application

Shuo Qi et al.

Summary: In this study, aptamers against beta-Lg were successfully selected and used to construct a novel fluorescence-surface enhanced Raman scattering dual-mode aptasensor for efficient and sensitive detection of the allergen. The aptasensor exhibited a broader linear range and a low detection limit, showing good stability and recoveries in real samples.

SENSORS AND ACTUATORS B-CHEMICAL (2021)

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Review Chemistry, Analytical

Mapping the gaps in chemical analysis for the characterisation of aptamer-target interactions

Elise Daems et al.

Summary: Aptamers are versatile biorecognition elements with wide applicability, requiring thorough characterization of their binding performance in the presence of the target for successful use. Various multi-analytical approaches are available to understand the aptamer-target interaction, highlighting the importance of considering the final application and limitations of analytical tools in the characterisation process.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2021)

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Article Medicine, Research & Experimental

The role of SAXS and molecular simulations in 3D structure elucidation of a DNA aptamer against lung cancer

Dmitry Morozov et al.

Summary: Aptamers, short DNA or RNA molecules, bind to target molecules with specificity, with affinity depending on their tertiary structure and charge distribution. Optimizing length and structure is crucial for improving aptamer specificity and affinity. LC-18t, a truncated version of aptamer LC-18, showed stronger binding to cancerous cells in lung tumor tissues and shared the binding site with the original aptamer.

MOLECULAR THERAPY-NUCLEIC ACIDS (2021)

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Article Chemistry, Multidisciplinary

Rapid and Efficient Detection of the SARS-CoV-2 Spike Protein Using an Electrochemical Aptamer-Based Sensor

Andrea Idili et al.

Summary: This study developed an electrochemical aptamer-based sensor for the rapid, reagentless, and quantitative measurement of the SARS-CoV-2 spike protein, demonstrating its sensitivity and specificity in biological fluids and highlighting its clinical potential for rapid detection.

ACS SENSORS (2021)

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Article Materials Science, Multidisciplinary

Ultrasensitive Detection of Dopamine, IL-6 and SARS-CoV-2 Proteins on Crumpled Graphene FET Biosensor

Michael Taeyoung Hwang et al.

Summary: Research on using crumpled graphene FET for bio-sensing has successfully detected various biomarkers, including small molecules and proteins. The performance of the sensors was optimized by studying the impact of crumpling ratio on electrical double layer formation and bandgap opening on the graphene.

ADVANCED MATERIALS TECHNOLOGIES (2021)

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Article Polymer Science

Hybrid aptamer-molecularly imprinted polymer (AptaMIP) nanoparticles selective for the antibiotic moxifloxacin

Mark V. Sullivan et al.

Summary: By incorporating modified thymine bases with polymerizable groups into an aptamer sequence, aptaMIP NP system combines the recognition properties of aptamer with the stability of MIP, offering superior molecular recognition for antibiotic moxifloxacin. The aptaMIP nanoparticles exhibit 10-fold higher binding affinity and selectivity compared to conventional MIP nanoparticles, with improved detection limits on a Surface Plasmon Resonance sensor platform.

POLYMER CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

New insight into the aptamer conformation and aptamer/protein interaction by surface-enhanced Raman scattering and multivariate statistical analysis

Wafa Safar et al.

Summary: By utilizing surface-enhanced Raman scattering and multivariate statistical analysis, we studied the interaction between an aptamer and its analyte, observing the structural changes of the aptamer under different experimental conditions and revealing the impact of the interaction with MnSOD. The data from principal component analysis of SERS spectra allowed us to probe the conformation and orientation of the aptamer relative to the surface, showing that the flexibility of the aptamer is greatly affected by the presence of a 15-thymine spacer and the experimental conditions.

NANOSCALE (2021)

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Article Chemistry, Analytical

Dual sensitive and rapid detection of glycated human serum albumin using a versatile lead/graphene nanocomposite probe as a fluorescence-electrochemical aptasensor

Thitirat Putnin et al.

Summary: The study developed a versatile fluorescence-electrochemical aptasensor for the quantification of GHSA using a GO-Pb complex probe, showing a linear relationship and detection limits. The platform demonstrated good selectivity and stability, with potential applications in clinical sample analysis.

ANALYST (2021)

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Review Chemistry, Multidisciplinary

DNA nanostructure-based nucleic acid probes: construction and biological applications

Dong-Xia Wang et al.

Summary: DNA nanostructure-based probes have shown advantages such as enhanced cell internalization efficiency and accelerated reaction rate, thus improving the efficiency of applications in biosensing, imaging analysis, and cell assembly.

CHEMICAL SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Rationally Designed Multivalent Aptamers Targeting Cell Surface for Biomedical Applications

Meihua Lin et al.

Summary: Specific interactions between ligands and receptors on cell surface are crucial in cell biology. Nucleic acid aptamers, as common ligands, enable specific recognition and tight binding to membrane protein receptors for potential cancer diagnosis and targeted therapy. However, challenges exist due to rapid degradation and clearance, prompting the development of multivalent aptamers for enhanced performance in physiological conditions.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Microbiology

An Ultrastructural Study of the Extruded Polar Tube of Anncaliia algerae (Microsporidia)

Peter M. Takvorian et al.

JOURNAL OF EUKARYOTIC MICROBIOLOGY (2020)

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Review Food Science & Technology

Recent developments in molecular docking technology applied in food science: a review

Xuan Tao et al.

INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY (2020)

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Article Biochemistry & Molecular Biology

Liquid-liquid phase separation and fibrillation of the prion protein modulated by a high-affinity DNA aptamer

Carolina O. Matos et al.

FASEB JOURNAL (2020)

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Article Chemistry, Analytical

Competitive electrochemical aptasensor based on a cDNA-ferrocene/MXene probe for detection of breast cancer marker Mucin1

Haiyan Wang et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

A Sequential Multidimensional Analysis Algorithm for Aptamer Identification based on Structure Analysis and Machine Learning

Jia Song et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Analytical

Fluorescence Polarization-Based Rapid Detection System for Salivary Biomarkers Using Modified DNA Aptamers Containing Base-Appended Bases

Hirotaka Minagawa et al.

ANALYTICAL CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Investigation of the interaction between split aptamer and vascular endothelial growth factor 165 using single molecule force spectroscopy

Shaoyuan Li et al.

JOURNAL OF MOLECULAR RECOGNITION (2020)

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Article Chemistry, Organic

Synthesis of Trifluoromethylated Purine Ribonucleotides and Their Evaluation as 19F NMR Probes

Mikolaj Chrominski et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

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Article Biochemistry & Molecular Biology

Automated cryo-lamella preparation for high-throughput in-situ structural biology

Genevieve Buckley et al.

JOURNAL OF STRUCTURAL BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Splitting aptamers and nucleic acid enzymes for the development of advanced biosensors

Megane Debiais et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Biochemistry & Molecular Biology

The complex formed between a synthetic RNA aptamer and the transcription repressor TetR is a structural and functional twin of the operator DNA-TetR regulator complex

Florian C. Grau et al.

NUCLEIC ACIDS RESEARCH (2020)

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Review Biochemistry & Molecular Biology

Developments, applications, and prospects of cryo-electron microscopy

Xu Benjin et al.

PROTEIN SCIENCE (2020)

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Article Biochemistry & Molecular Biology

Pyrene-Modified DNA Aptamers with High Affinity to Wild-Type EGFR and EGFRvIII

Elena Zavyalova et al.

NUCLEIC ACID THERAPEUTICS (2020)

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Review Chemistry, Analytical

Aptamer binding assays and molecular interaction studies using fluorescence anisotropy - A review

Qiang Zhao et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Exonuclease I-Assisted General Strategy to Convert Aptamer-Based Electrochemical Biosensors from Signal-Off to Signal-On

Xiaoyi Gao et al.

ANALYTICAL CHEMISTRY (2020)

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Article Multidisciplinary Sciences

In silico design and validation of high-affinity RNA aptamers targeting epithelial cellular adhesion molecule dimers

David R. Bell et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Chemistry, Analytical

Mapping the binding region of aptamer targeting small molecule: Dabigatran etexilate, an anti-coagulant

Maher M. Aljohani et al.

TALANTA (2020)

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Article Multidisciplinary Sciences

Aptamer-based optical manipulation of protein subcellular localization in cells

Sitao Xie et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins

Malwina Hyjek-Skladanowska et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Biochemistry & Molecular Biology

The geometric influence on the Cys2His2 zinc finger domain and functional plasticity

April L. Mueller et al.

NUCLEIC ACIDS RESEARCH (2020)

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Article Chemistry, Analytical

Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein

Yanling Song et al.

ANALYTICAL CHEMISTRY (2020)

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Article Chemistry, Multidisciplinary

Periodically Ordered, Nuclease-Resistant DNA Nanowires Decorated with Cell-Specific Aptamers as Selective Theranostic Agents

Chang Xue et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Review Biochemistry & Molecular Biology

Chemical Modification of Aptamers for Increased Binding Affinity in Diagnostic Applications: Current Status and Future Prospects

Jan P. Elskens et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biochemistry & Molecular Biology

The precious fluorine on the ring: fluorine NMR for biological systems

Andras Boeszoermenyi et al.

JOURNAL OF BIOMOLECULAR NMR (2020)

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Article Chemistry, Analytical

Docking Simulation and Sandwich Assay for Aptamer-Based Botulinum Neurotoxin Type C Detection

In-Hwan Oh et al.

BIOSENSORS-BASEL (2020)

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Article Chemistry, Analytical

Screening and application of a truncated aptamer for high-sensitive fluorescent detection of metronidazole

Hao Wei et al.

ANALYTICA CHIMICA ACTA (2020)

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Article Chemistry, Analytical

Engineering and Application of a Myoglobin Binding Split Aptamer

Shaoyuan Li et al.

ANALYTICAL CHEMISTRY (2020)

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5′-fluoro(di)phosphate-labeled oligonucleotides are versatile molecular probes for studying nucleic acid secondary structure and interactions by 19F NMR

Marek R. Baranowski et al.

NUCLEIC ACIDS RESEARCH (2020)

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Structural basis of prostate-specific membrane antigen recognition by the A9g RNA aptamer

Jakub Ptacek et al.

NUCLEIC ACIDS RESEARCH (2020)

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RNA aptamer capture of macromolecular complexes for mass spectrometry analysis

Judhajeet Ray et al.

NUCLEIC ACIDS RESEARCH (2020)

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Modified Nucleic Acids: Expanding the Capabilities of Functional Oligonucleotides

Steven Ochoa et al.

MOLECULES (2020)

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Quartz crystal microbalances (QCM) are suitable for real-time dosimetry in nanotoxicological studies using VITROCELL®Cloud cell exposure systems

Yaobo Ding et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

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Directing a rational design of aptamer-based fluorescence anisotropy assay for sensitive detection of immunoglobulin E by site-specific binding study

Qiang Zhao et al.

TALANTA (2020)

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Improved Cancer Targeting by Multimerizing Aptamers on Nanoscaffolds

Marjan Omer et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

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Discovery of cell-internalizing artificial nucleic acid aptamers for lung fibroblasts and targeted drug delivery

Hiro Uemachi et al.

BIOORGANIC CHEMISTRY (2020)

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Development of a CD63 Aptamer for Efficient Cancer Immunochemistry and Immunoaffinity-Based Exosome Isolation

Zhenguo Song et al.

MOLECULES (2020)

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Aptamer BC 007 - Efficient binder of spreading-crucial SARS-CoV-2 proteins

Hardy Weisshoff et al.

HELIYON (2020)

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Methods and Applications of In Silico Aptamer Design and Modeling

Andrey A. Buglak et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition

Claudia Riccardi et al.

MOLECULES (2020)

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Article Biochemical Research Methods

Lighting Up the Thrombin-Binding Aptamer G-Quadruplex with an Internal Cyanine-Indole-Quinolinium Nucleobase Surrogate. Direct Fluorescent Intensity Readout for Thrombin Binding without Topology Switching

Micaela D. Gray et al.

BIOCONJUGATE CHEMISTRY (2020)

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Aptamer-Based Western Blot for Selective Protein Recognition

Yao Wang et al.

FRONTIERS IN CHEMISTRY (2020)

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Quartz crystal microbalance-based biosensors as rapid diagnostic devices for infectious diseases

Hui Jean Lim et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Extended Metal-Organic Frameworks on Diverse Supports as Electrode Nanomaterials for Electrochemical Energy Storage

Kaiqiang Zhang et al.

ACS APPLIED NANO MATERIALS (2020)

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Targeting prostate cancer: Prostate-specific membrane antigen based diagnosis and therapy

Till Wuestemann et al.

MEDICINAL RESEARCH REVIEWS (2019)

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Collision of Aptamer/Pt Nanoparticles Enables Label-Free Amperometric Detection of Protein in Rat Brain

Yue Zhang et al.

ANALYTICAL CHEMISTRY (2019)

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Enhanced Dispersion and Polarization Interactions Achieved through Dithiophosphate Group Incorporation Yield a Dramatic Binding Affinity Increase for an RNA Aptamer-Thrombin Complex

Martin Egli et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Review Biochemistry & Molecular Biology

Recent Advances in Aptamer Discovery and Applications

Yang Zhang et al.

MOLECULES (2019)

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Identifying coupled clusters of allostery participants through chemical shift perturbations

Yunyao Xu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

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Surface plasmon resonance aptasensor for detection of human activated protein C

Seda Koyun et al.

TALANTA (2019)

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Molecular Engineering-Based Aptamer-Drug Conjugates with Accurate Tunability of Drug Ratios for Drug Combination Targeted Cancer Therapy

Fang Zhou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Article Biochemistry & Molecular Biology

DNA-Nanoscaffold-Assisted Selection of Femtomolar Bivalent Human α-Thrombin Aptamers with Potent Anticoagulant Activity

Yu Zhou et al.

CHEMBIOCHEM (2019)

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A fluorometric aptamer nanoprobe for alpha-fetoprotein by exploiting the FRET between 5-carboxyfluorescein and palladium nanoparticles

Guiyin Li et al.

MICROCHIMICA ACTA (2019)

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Article Biochemistry & Molecular Biology

Highly stable hexitol based XNA aptamers targeting the vascular endothelial growth factor

Elena Eremeeva et al.

NUCLEIC ACIDS RESEARCH (2019)

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Unravelling the lipocalin 2 interaction with aptamers: May rolling circle amplification improve their functional affinity?

Ramon Lorenzo-Gomez et al.

TALANTA (2019)

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Single-molecule detection of proteins and toxins in food using atomic force microscopy

R. Alexander Reese et al.

TRENDS IN FOOD SCIENCE & TECHNOLOGY (2019)

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Fabrication of Polymeric Ferrocene Nanoparticles for Electrochemical Aptasensing of Protein with Target-Catalyzed Hairpin Assembly

Hua Chai et al.

ANALYTICAL CHEMISTRY (2019)

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A Simple, pH-Activatable Fluorescent Aptamer Probe with Ultralow Background for Bispecific Tumor Imaging

Hui Shi et al.

ANALYTICAL CHEMISTRY (2019)

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Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications

Mengjiao Huang et al.

ANALYTICAL CHEMISTRY (2019)

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Elucidation and Structural Modeling of CD71 as a Molecular Target for Cell-Specific Aptamer Binding

Xiaoqiu Wu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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A DNA aptamer reveals an allosteric site for inhibition in metallo-β-lactamases

Nazmul H. Khan et al.

PLOS ONE (2019)

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Dual Aptamer-Functionalized 3D Plasmonic Metamolecule for Thrombin Sensing

Timon Funck et al.

APPLIED SCIENCES-BASEL (2019)

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Review Chemistry, Multidisciplinary

Recent progress in nanomaterial-enhanced fluorescence polarization/anisotropy sensors

Jia Chen et al.

CHINESE CHEMICAL LETTERS (2019)

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Natural constituents of St. John's Wort inhibit the proteolytic activity of human thrombin

Ling-Hua Wei et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

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A DNA-Based Biosensor Assay for the Kinetic Characterization of Ion-Dependent Aptamer Folding and Protein Binding

Irene Ponzo et al.

MOLECULES (2019)

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Molecular affinity rulers: systematic evaluation of DNA aptamers for their applicabilities in ELISA

Michiko Kimoto et al.

NUCLEIC ACIDS RESEARCH (2019)

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CRISPR/dual-FRET molecular beacon for sensitive live-cell imaging of non-repetitive genomic loci

Shiqi Mao et al.

NUCLEIC ACIDS RESEARCH (2019)

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Advances in aptamer screening technologies

Jianhua Yan et al.

TALANTA (2019)

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Perspective on the Future Role of Aptamers in Analytical Chemistry

Yao Wu et al.

ANALYTICAL CHEMISTRY (2019)

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Engineering Aptamer with Enhanced Affinity by Triple Helix-Based Terminal Fixation

Lianhui Zhao et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)

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Electrochemical selection of a DNA aptamer, and an impedimetric method for determination of the dedicator of cytokinesis 8 by self-assembly of a thiolated aptamer on a gold electrode

Shimaa Eissa et al.

MICROCHIMICA ACTA (2019)

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Aptamers: A Review of Their Chemical Properties and Modifications for Therapeutic Application

Tatsuo Adachi et al.

MOLECULES (2019)

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Regulation of Protein Activity and Cellular Functions Mediated by Molecularly Evolved Nucleic Acids

Jie Tan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

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Three decades of nucleic acid aptamer technologies: Lessons learned, progress and opportunities on aptamer development

Tao Wang et al.

BIOTECHNOLOGY ADVANCES (2019)

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Electrochemical aptasensor for activated protein C using a gold nanoparticle - Chitosan/graphene paste modified carbon paste electrode

Maryam Hosseini Ghalehno et al.

BIOELECTROCHEMISTRY (2019)

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Recent advances on thermosensitive and pH-sensitive liposomes employed in controlled release

Marjan Abri Aghdam et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Re-Engineering RNA Molecules into Therapeutic Agents

Martin Egli et al.

ACCOUNTS OF CHEMICAL RESEARCH (2019)

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An off-on phosphorescent aptasensor for the detection of thrombin based on PRET

Yan Xiong et al.

ANALYST (2019)

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Sensitive and sustained imaging of intracellular microRNA in living cells by a high biocompatible liposomal vehicle introduced isothermal symmetric exponential amplification reaction

Wen Yin et al.

CHEMICAL COMMUNICATIONS (2019)

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Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients

Lidiya Z. Kukova et al.

JOURNAL OF APPLIED LABORATORY MEDICINE (2019)

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Aptamer chemistry

Pascal Rothlisberger et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Azoreductase and Target Simultaneously Activated Fluorescent Monitoring for Cytochrome c Release under Hypoxia

Jianru Tang et al.

ANALYTICAL CHEMISTRY (2018)

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Thermodynamic study of aptamers binding to their target proteins

Taiichi Sakamoto et al.

BIOCHIMIE (2018)

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DNA aptamer generation by ExSELEX using genetic alphabet expansion with a mini-hairpin DNA stabilization method

Ichiro Hirao et al.

BIOCHIMIE (2018)

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Recent advances on aptamer-based biosensors to detection of platelet-derived growth factor

Nasrin Razmi et al.

BIOSENSORS & BIOELECTRONICS (2018)

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Development of a SPR aptasensor containing oriented aptamer for direct capture and detection of tetracycline in multiple honey samples

Sai Wang et al.

BIOSENSORS & BIOELECTRONICS (2018)

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Surface-Enhanced Raman Spectroscopy for Bioanalysis: Reliability and Challenges

Cheng Zong et al.

CHEMICAL REVIEWS (2018)

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Analysis of Evolutionarily Independent Protein-RNA Complexes Yields a Criterion to Evaluate the Relevance of Prebiotic Scenarios

Celia Blanco et al.

CURRENT BIOLOGY (2018)

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Effect of PDGF-B aptamer on PDGFRβ/PDGF-B interaction: Molecular dynamics study

Cong Quang Vu et al.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2018)

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Nanosized aptameric cavities imprinted on the surface of magnetic nanoparticles for high-throughput protein recognition

Elham Shoghi et al.

MICROCHIMICA ACTA (2018)

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Combination of aptamer and drug for reversible anticoagulation in cardiopulmonary bypass

Ruwan Gunaratne et al.

NATURE BIOTECHNOLOGY (2018)

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Cryo-EM in drug discovery: achievements, limitations and prospects

Jean-Paul Renaud et al.

NATURE REVIEWS DRUG DISCOVERY (2018)

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Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity

Rafal Dolot et al.

NUCLEIC ACIDS RESEARCH (2018)

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DNA-protein interactions explored by atomic force microscopy

S. Kasas et al.

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2018)

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Analysis of Global and Site-Specific Radiation Damage in Cryo-EM

Johan Hattne et al.

STRUCTURE (2018)

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Nanomolar binding affinity of quinine-based antimalarial compounds by the cocaine-binding aptamer

Sladjana Slavkovic et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2018)

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A three-dimensional graphene-based ratiometric signal amplification aptasensor for MUC1 detection

Shaohong Yang et al.

BIOSENSORS & BIOELECTRONICS (2018)

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Targeted VEGF-triggered release of an anti-cancer drug from aptamer-functionalized metal-organic framework nanoparticles

Wei-Hai Chen et al.

NANOSCALE (2018)

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Structural interpretation of DNA-protein hydroxyl-radical footprinting experiments with high resolution using HYDROID

Alexey K. Shaytan et al.

NATURE PROTOCOLS (2018)

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Aptamers and Aptasensors for Highly Specific Recognition and Sensitive Detection of Marine Biotoxins: Recent Advances and Perspectives

Lianhui Zhao et al.

TOXINS (2018)

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Investigations on the interface of nucleic acid aptamers and binding targets

Shundong Cai et al.

ANALYST (2018)

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Epitope Binning Assay Using an Electron Transfer-Modulated Aptamer Sensor

Min Li et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Nucleic Acid Biosensors: Recent Advances and Perspectives

Yan Du et al.

ANALYTICAL CHEMISTRY (2017)

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High-Affinity DNA Aptamer Generation Targeting von Willebrand Factor A1-Domain by Genetic Alphabet Expansion for Systematic Evolution of Ligands by Exponential Enrichment Using Two Types of Libraries Composed of Five Different Bases

Ken-ichiro Matsunaga et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Article Radiology, Nuclear Medicine & Medical Imaging

Band Inversion Amplifies 31P-31P Nuclear Overhauser Effects: Relaxation Mechanism and Dynamic Behavior of ATP in the Human Brain by 31P MRS at 7 T

Jimin Ren et al.

MAGNETIC RESONANCE IN MEDICINE (2017)

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Aptamers as targeted therapeutics: current potential and challenges

Jiehua Zhou et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

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Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers

Andrea Pica et al.

NUCLEIC ACIDS RESEARCH (2017)

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Probing the HIV-1 NCp7 Nucleocapsid Protein with Site-Specific Gold(I)-Phosphine Complexes

Raphael E. F. de Paiva et al.

INORGANIC CHEMISTRY (2017)

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Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Shuaijian Ni et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

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Aptamer-based liposomes improve specific drug loading and release

Kevin Plourde et al.

JOURNAL OF CONTROLLED RELEASE (2017)

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Selection of 2'-Fluoro-Modified Aptamers with Optimized Properties

Deepak Thirunavukarasu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Micellar Thrombin-Binding Aptamers: Reversible Nanoscale Anticoagulants

Alexander Roloff et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Molecular Elucidation of Disease Biomarkers at the Interface of Chemistry and Biology

Liqin Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

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Selection of aptamers based on a protein microarray integrated with a microfluidic chip

Xiaohui Liu et al.

LAB ON A CHIP (2017)

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The Exact Nuclear Overhauser Enhancement: Recent Advances

Parker J. Nichols et al.

MOLECULES (2017)

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Silver nanoparticle plasmonic enhanced forster resonance energy transfer (FRET) imaging of protein-specific sialylation on the cell surface

Tingbi Zhao et al.

NANOSCALE (2017)

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Aptasensor based optical detection of glycated albumin for diabetes mellitus diagnosis

Shreya Ghosh et al.

NANOTECHNOLOGY (2017)

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Detection of nucleic acid-protein interactions in plant leaves using fluorescence lifetime imaging microscopy

Laurent Camborde et al.

NATURE PROTOCOLS (2017)

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Ligand binding to 2′-deoxyguanosine sensing riboswitch in metabolic context

Yong-Boum Kim et al.

NUCLEIC ACIDS RESEARCH (2017)

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mCSM-NA: predicting the effects of mutations on protein-nucleic acids interactions

Douglas E. V. Pires et al.

NUCLEIC ACIDS RESEARCH (2017)

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Selection of DNA aptamers with two modified bases

Bharat N. Gawande et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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High performance formaldehyde detection based on a novel copper (II) complex functionalized QCM gas sensor

Luyu Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2017)

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Highly sensitive amperometric detection of cardiac troponin I using sandwich aptamers and screen-printed carbon electrodes

Hunho Jo et al.

TALANTA (2017)

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Aptamer-based assay of biomolecules: Recent advances in electro-analytical approach

Mohammad Hasanzadeh et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2017)

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A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva

Haixiang Yu et al.

CHEMICAL SCIENCE (2017)

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Sortilin limits EGFR signaling by promoting its internalization in lung cancer

Hussein Al-Akhrass et al.

NATURE COMMUNICATIONS (2017)

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A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer

Fangfei Li et al.

NATURE COMMUNICATIONS (2017)

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Nanoscale π-π stacked molecules are bound by collective charge fluctuations

Jan Hermann et al.

NATURE COMMUNICATIONS (2017)

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Oligonucleotide Hybridization Combined with Competitive Antibody Binding for the Truncation of a High-Affinity Aptamer

Cong Quang Vu et al.

ACS COMBINATORIAL SCIENCE (2017)

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Analysis of aptamer discovery and technology

Matthew R. Dunn et al.

Nature Reviews Chemistry (2017)

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Multifaceted analyses of the interactions between human heart type fatty acid binding protein and its specific aptamers

Ankana Kakoti et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Fluorescence-Free Biosensor Methods in Detection of Food Pathogens with a Special Focus on Listeria monocytogenes

Rajeswaran Radhakrishnan et al.

BIOSENSORS-BASEL (2017)

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Article Electrochemistry

Label-free electrochemical aptasensor based on gold and polypyrrole nanoparticles for interleukin 6 detection

Mihaela Tertis et al.

ELECTROCHIMICA ACTA (2017)

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Quantitative determination of testosterone levels with biolayer interferometry

Hao Zhang et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2017)

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Origins of the enhanced affinity of RNA-protein interactions triggered by RNA phosphorodithioate backbone modification

Xianbin Yang et al.

CHEMICAL COMMUNICATIONS (2017)

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ATP-Responsive Aptamer-Based Metal-Organic Framework Nanoparticles (NMOFs) for the Controlled Release of Loads and Drugs

Wei-Hai Chen et al.

ADVANCED FUNCTIONAL MATERIALS (2017)

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Reduced graphene oxide-chitosan-aptamer interface as new platform for ultrasensitive detection of human epidermal growth factor receptor 2

Arezoo Tabasi et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Rotation of Guanine Amino Groups in G-Quadruplexes: A Probe for Local Structure and Ligand Binding

Michael Adrian et al.

BIOPHYSICAL JOURNAL (2017)

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Detection of a cancer biomarker protein on modified cellulose paper by fluorescence using aptamer-linked quantum dots

Pradip Das et al.

ANALYST (2017)

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Substituent Effects in Parallel- Displaced π-π Stacking Interactions: Distance Matters

Leslie-Joana Riwar et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Analyzing Liposomal Drug Delivery Systems in Three-Dimensional Cell Culture Models Using MALDI Imaging Mass Spectrometry

Jessica K. Lukowski et al.

ANALYTICAL CHEMISTRY (2017)

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Article Oncology

Selection of DNA aptamers for extra cellular domain of human epidermal growth factor receptor 2 to detect HER2 positive carcinomas

A. Sett et al.

CLINICAL & TRANSLATIONAL ONCOLOGY (2017)

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Ultrasensitive detection of nucleic acids and proteins using quartz crystal microbalance and surface plasmon resonance sensors based on target-triggering multiple signal amplification strategy

Wenbo Sun et al.

ANALYTICA CHIMICA ACTA (2017)

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Article Chemistry, Analytical

Stepping Library-Based Post-SELEX Strategy Approaching to the Minimized Aptamer in SPR

Xiaoqin He et al.

ANALYTICAL CHEMISTRY (2017)

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Gold Nanostar Enhanced Surface Plasmon Resonance Detection of an Antibiotic at Attomolar Concentrations via an Aptamer-Antibody Sandwich Assay

Suhee Kim et al.

ANALYTICAL CHEMISTRY (2017)

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Synthesis of Intrinsically Disordered Fluorinated Peptides for Modular Design of High-Signal 19F MRI Agents

Steven E. Kirberger et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

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Review Biochemistry & Molecular Biology

G-quadruplex-based aptamers against protein targets in therapy and diagnostics

Chiara Platella et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2017)

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Selective Fluorogenic Sensing of As(III) Using Aptamer-Capped Nanomaterials

Mar Oroval et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

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Zinc-finger proteins in health and disease

Matteo Cassandri et al.

CELL DEATH DISCOVERY (2017)

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Development of a screen-printed carbon electrode based disposable enzyme sensor strip for the measurement of glycated albumin

Mika Hatada et al.

BIOSENSORS & BIOELECTRONICS (2017)

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Recent Progress in Molecular Recognition Imaging Using Atomic Force Microscopy

Subhadip Senapati et al.

ACCOUNTS OF CHEMICAL RESEARCH (2016)

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Self-Assembled DNA Nanocentipede as Multivalent Drug Carrier for Targeted Delivery

Wenshan Li et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Aptamers: versatile molecular recognition probes for cancer detection

Hongguang Sun et al.

ANALYST (2016)

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Post-SELEX optimization of aptamers

Shunxiang Gao et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2016)

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Rapid agarose gel electrophoretic mobility shift assay for quantitating protein: RNA interactions

Jennifer A. Ream et al.

ANALYTICAL BIOCHEMISTRY (2016)

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Applications of Optical Microcavity Resonators in Analytical Chemistry

James H. Wade et al.

ANNUAL REVIEW OF ANALYTICAL CHEMISTRY, VOL 9 (2016)

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Kinetic and Thermodynamic Analyses of Interaction between a High Affinity RNA Aptamer and Its Target Protein

Ryo Amano et al.

BIOCHEMISTRY (2016)

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Inhibitory effect on the proliferation of human heptoma induced by cell-permeable manganese superoxide dismutase

Hua Guo et al.

BIOMEDICINE & PHARMACOTHERAPY (2016)

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A novel electrochemical immunosensor based on nonenzymatic Ag@Au-Fe3O4 nanoelectrocatalyst for protein biomarker detection

Hongfang Zhang et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Integrated microfluidic device using a single universal aptamer to detect multiple types of influenza viruses

Chih-Hung Wang et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Rapid detection of acute myocardial infarction-related miRNA based on a Capture-interCalation-electroCatalysis (3C) strategy

Guifang Chen et al.

BIOSENSORS & BIOELECTRONICS (2016)

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Review Biotechnology & Applied Microbiology

Voltammetric aptasensors for protein disease biomarkers detection: A review

Sofia G. Meirinho et al.

BIOTECHNOLOGY ADVANCES (2016)

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Tumor cell-specific split aptamers: target-driven and temperature-controlled self-assembly on the living cell surface

Jinlu Tang et al.

CHEMICAL COMMUNICATIONS (2016)

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Detection of C-reactive protein using nanoparticle- enhanced surface plasmon resonance using an aptamer-antibody sandwich assay

Bin Wu et al.

CHEMICAL COMMUNICATIONS (2016)

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Aptamer-integrated DNA nanostructures for biosensing, bioimaging and cancer therapy

Hong-Min Meng et al.

CHEMICAL SOCIETY REVIEWS (2016)

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SELEX Modifications and Bioanalytical Techniques for Aptamer-Target Binding Characterization

Sze Y. Tan et al.

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY (2016)

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Embracing proteins: structural themes in aptamer-protein complexes

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CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)

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A label- free multi-functionalized electrochemical aptasensor based on a Fe3O4@3D-rGO@plasma-polymerized (4-vinyl pyridine) nanocomposite for the sensitive detection of proteins in whole blood

Shaoming Fang et al.

ELECTROCHIMICA ACTA (2016)

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Testing for myositis specific autoantibodies: Comparison between line blot and immunoprecipitation assays in 57 myositis sera

Ilaria Cavazzana et al.

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Theoretical Characterization of the H-Bonding and Stacking Potential of Two Nonstandard Nucleobases Expanding the Genetic Alphabet

Mohit Chawla et al.

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Methods for Improving Aptamer Binding Affinity

Hijiri Hasegawa et al.

MOLECULES (2016)

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Structural basis for specific inhibition of Autotaxin by a DNA aptamer

Kazuki Kato et al.

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Evoking picomolar binding in RNA by a single phosphorodithioate linkage

N. Dinuka Abeydeera et al.

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Comprehensive evaluation of ten docking programs on a diverse set of protein-ligand complexes: the prediction accuracy of sampling power and scoring power

Zhe Wang et al.

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Development of a Quantitative BRET Affinity Assay for Nucleic Acid-Protein Interactions

Timothy A. Vickers et al.

PLOS ONE (2016)

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In vitro evolution of chemically-modified nucleic acid aptamers: Pros and cons, and comprehensive selection strategies

Farhana Lipi et al.

RNA BIOLOGY (2016)

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Wavelike charge density fluctuations and van der Waals interactions at the nanoscale

Alberto Ambrosetti et al.

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Selection and Characterization of Aptamers Using a Modified Whole Cell Bacterium SELEX for the Detection of Salmonella enterica Serovar Typhimurium

Padma Sudha Rani Lavu et al.

ACS COMBINATORIAL SCIENCE (2016)

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Structural basis for specific inhibition of Autotaxin by a DNA aptamer

Kazuki Kato et al.

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Truncation and Mutation of a Transferrin Receptor Aptamer Enhances Binding Affinity

Joanna Macdonald et al.

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Expected and unexpected features of protein-binding RNA aptamers

Nils Bjerregaard et al.

WILEY INTERDISCIPLINARY REVIEWS-RNA (2016)

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Nanostructure-based surface-enhanced Raman scattering biosensors for nucleic acids and proteins

Jie Chao et al.

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Small-Molecule Binding Aptamers: Selection Strategies, Characterization, and Applications

Annemaria Ruscito et al.

FRONTIERS IN CHEMISTRY (2016)

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Improved Aptamers for the Diagnosis and Potential Treatment of HER2-Positive Cancer

Marlies Gijs et al.

PHARMACEUTICALS (2016)

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Highly specific detection of thrombin using an aptamer-based suspension array and the interaction analysis via microscale thermophoresis

Yanan Liu et al.

ANALYST (2015)

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Carbon Nanotubes Labeled with Aptamer and Horseradish Peroxidase as a Probe for Highly Sensitive Protein Biosensing by Postelectropolymerization of Insoluble Precipitates on Electrodes

Jing Li et al.

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Evaluation of Medicine Effects on the Interaction of Myoglobin and Its Aptamer or Antibody Using Atomic Force Microscopy

Qing Wang et al.

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Aptamer Recognition Induced Target-Bridged Strategy for Proteins Detection Based on Magnetic Chitosan and Silver/Chitosan Nanoparticles Using Surface-Enhanced Raman Spectroscopy

Jincan He et al.

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Aptamer Pseudoknot-Functionalized Electronic Sensor for Reagent less and Single-Step Detection of Immunoglobulin E in Human Serum

Bingying Jiang et al.

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Ultrasensitive Colorimetric Detection of 17β-Estradiol: The Effect of Shortening DNA Aptamer Sequences

Omar A. Alsager et al.

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Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis

Anja Konzack et al.

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Quartz crystal microbalance detection of protein amplified by nicked circling, rolling circle amplification and biocatalytic precipitation

Xiaoru Zhang et al.

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Detecting multiple cell-secreted cytokines from the same aptamer-functionalized electrode

Ying Liu et al.

BIOSENSORS & BIOELECTRONICS (2015)

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Single-Particle Cryo-EM at Crystallographic Resolution

Yifan Cheng

CELL (2015)

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Nucleic acid aptamers in cancer research, diagnosis and therapy

Haitao Ma et al.

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High Sensitivity, High Selectivity SERS Detection of MnSOD Using Optical Nanoantennas Functionalized with Aptamers

Maxirnilien Cottat et al.

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Structural Basis for a Six Nucleotide Genetic Alphabet

Millie M. Georgiadis et al.

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Evolution of Functional Six-Nucleotide DNA

Liqin Zhang et al.

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Protein Activity Regulation: Inhibition by Closed-Loop Aptamer-Based Structures and Restoration by Near-IR Stimulation

Jie Wang et al.

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Fluorescence Activation Imaging of Cytochrome c Released from Mitochondria Using Aptameric Nanosensor

Ting-Ting Chen et al.

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Predicting the Uncertain Future of Aptamer-Based Diagnostics and Therapeutics

John G. Bruno

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Ewen Callaway

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Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

Edyta Marcon et al.

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Preparation and biomedical applications of programmable and multifunctional DNA nanoflowers

Yifan Lv et al.

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NPDock: a web server for protein-nucleic acid docking

Irina Tuszynska et al.

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A novel method for the study of molecular interaction by using microscale thermophoresis

Yexuan Mao et al.

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Functionalizing Liposomes with anti-CD44 Aptamer for Selective Targeting of Cancer Cells

Walhan Alshaer et al.

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Target-Induced Conjunction of Split Aptamer Fragments and Assembly with a Water-Soluble Conjugated Polymer for Improved Protein Detection

Xingfen Liu et al.

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Using 19F NMR to Probe Biological Interactions of Proteins and Peptides

E. Neil G. Marsh et al.

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Aptamer-based biosensors for biomedical diagnostics

Wenhu Zhou et al.

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Aptamer binding assays for proteins: The thrombin example-A review

Bin Deng et al.

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A colorimetric sandwich-type assay for sensitive thrombin detection based on enzyme-linked aptamer assay

Jun Hee Park et al.

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Monitoring Aptamer-Protein Interactions Using Tunable Resistive Pulse Sensing

Emily R. Billinge et al.

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Probing the Force-Induced Dissociation of Aptamer-Protein Complexes

Elena Perez-Ruiz et al.

ANALYTICAL CHEMISTRY (2014)

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Ultrasensitive detection of thrombin using surface plasmon resonance and quartz crystal microbalance sensors by aptamer-based rolling circle amplification and nanoparticle signal enhancement

Peng He et al.

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Short Linear Motifs: Ubiquitous and Functionally Diverse Protein Interaction Modules Directing Cell Regulation

Kim Van Roey et al.

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Recent progress in metal-organic complexes for optoelectronic applications

Hui Xu et al.

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Fluorine as a Hydrogen-Bond Acceptor: Experimental Evidence and Computational Calculations

Claudio Dalvit et al.

CHEMISTRY-A EUROPEAN JOURNAL (2014)

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Electrochemical immunoassay based on aptamer-protein interaction and functionalized polymer for cancer biomarker detection

Zahra Taleat et al.

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Intercalation binding of food antioxidant butylated hydroxyanisole to calf thymus DNA

Langhong Wang et al.

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Proteomics Analysis of Cancer Exosomes Using a Novel Modified Aptamer-based Array (SOMAscanTM) Platform*

Jason Webber et al.

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Developments in X-ray Crystallographic Structure Determination of Biological Macromolecules

Elspeth F. Garman

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Aptamer-conjugated nanomaterials for specific cancer cell recognition and targeted cancer therapy

Qiaoling Liu et al.

NPG ASIA MATERIALS (2014)

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Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

John C. Rohloff et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2014)

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Understanding Substituent Effects in Noncovalent Interactions Involving Aromatic Rings

Steven E. Wheeler

ACCOUNTS OF CHEMICAL RESEARCH (2013)

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Nanoparticles That Sense Thrombin Activity As Synthetic Urinary Biomarkers of Thrombosis

Kevin Y. Lin et al.

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Sampling a Biomarker of the Human Immunodeficiency Virus across a Synthetic Nanopore

David J. Niedzwiecki et al.

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Probing high-affinity 11-mer DNA aptamer against Lup an 1 (β-conglutin)

P. Nadal et al.

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Bioorthogonal Approach to Identify Unsuspected Drug Targets in Live Cells

Katherine S. Yang et al.

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Probing the RNA Binding Surface of the HIV-1 Nucleocapsid Protein by Site-Directed Mutagenesis

Wei Ouyang et al.

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Array sensing using optical methods for detection of chemical and biological hazards

Katharine L. Diehl et al.

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Biophysical characterization of VEGF-aHt DNA aptamer interactions

Indhu Kanakaraj et al.

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Optical Properties of a Particle above a Dielectric Interface: Cross Sections, Benchmark Calculations, and Analysis of the Intrinsic Substrate Effects

Jean Lerme et al.

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Efficacy of Base-Modification on Target Binding of Small Molecule DNA Aptamers

Yuri Imaizumi et al.

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DNAzyme Footprinting: Detecting Protein-Aptamer Complexation on Surfaces by Blocking DNAzyme Cleavage Activity

Yulin Chen et al.

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Application of Catalyst-Free Click Reactions in Attaching Affinity Molecules to Tips of Atomic Force Microscopy for Detection of Protein Biomarkers

Subhadip Senapati et al.

LANGMUIR (2013)

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Generation of high-affinity DNA aptamers using an expanded genetic alphabet

Michiko Kimoto et al.

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Anti-prion activity of an RNA aptamer and its structural basis

Tsukasa Mashima et al.

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Site-selective probing of cTAR destabilization highlights the necessary plasticity of the HIV-1 nucleocapsid protein to chaperone the first strand transfer

Julien Godet et al.

NUCLEIC ACIDS RESEARCH (2013)

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Elucidating Novel Serum Biomarkers Associated with Pulmonary Tuberculosis Treatment

Mary A. De Groote et al.

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Measurement of Cetuximab and Panitumumab-Unbound Serum EGFR Extracellular Domain Using an Assay Based on Slow Off-Rate Modified Aptamer (SOMAmer) Reagents

Noh Jin Park et al.

PLOS ONE (2013)

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Revealing the Positive Side of Fluorine

Ulrich Hennecke

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Aptamer-gold nanoparticle-based colorimetric assay for the sensitive detection of thrombin

Yi Peng et al.

SENSORS AND ACTUATORS B-CHEMICAL (2013)

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Direct access to aptamer-protein complexes via MALDI-MS

Fan Chen et al.

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Single-molecule atomic force microscopy on live cells compares aptamer and antibody rupture forces

Meghan B. O'Donoghue et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2012)

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Label-free and sensitive thrombin sensing on a molecularly grafted aptamer on graphene

Yanping Wang et al.

CHEMICAL COMMUNICATIONS (2012)

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Thrombin Binding Aptamer, More than a Simple Aptamer: Chemically Modified Derivatives and Biomedical Applications

Anna Avino et al.

CURRENT PHARMACEUTICAL DESIGN (2012)

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Characterization of Aptamer-Protein Complexes by X-ray Crystallography and Alternative Approaches

Vincent J. B. Ruigrok et al.

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A Logical Molecular Circuit for Programmable and Autonomous Regulation of Protein Activity Using DNA Aptamer-Protein Interactions

Da Han et al.

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PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells

Yuan Xue et al.

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Single-molecule pull-down for studying protein interactions

Ankur Jain et al.

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Novel biomarkers in chronic heart failure

Tariq Ahmad et al.

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Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targets

Douglas R. Davies et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Aptamer-Functionalized Silica Nanoparticles for Targeted Cancer Therapy

Athulya Aravind et al.

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Methods for measuring aptamer-protein equilibria: A review

Meng Jing et al.

ANALYTICA CHIMICA ACTA (2011)

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Measurement of Aptamer-Protein Interactions with Back-Scattering Interferometry

Ian R. Olmsted et al.

ANALYTICAL CHEMISTRY (2011)

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Gold Nanoparticles Presenting Hybridized Self-Assembled Aptamers That Exhibit Enhanced Inhibition of Thrombin

Yen-Chun Shiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

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Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding

Satoru Nagatoishi et al.

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A quantum dot-aptamer beacon using a DNA intercalating dye as the FRET reporter: Application to label-free thrombin detection

Chun-Wei Chi et al.

BIOSENSORS & BIOELECTRONICS (2011)

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Recent Advances in Electrochemical Aptamer-Based Sensors

Elena E. Ferapontova et al.

CURRENT ORGANIC CHEMISTRY (2011)

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Biophysical characterization of DNA and RNA aptamer interactions with hen egg lysozyme

Ajish S. R. Potty et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2011)

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Polymer Molecular Weight Analysis by 1H NMR Spectroscopy

Josephat U. Izunobi et al.

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Solution Thermodynamics and Preferential Solvation of Meloxicam in Propylene Glycol plus Water Mixtures

Andres R. Holguin et al.

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Fluorescence Anisotropy Analysis for Mapping Aptamer-Protein Interaction at the Single Nucleotide Level

Dapeng Zhang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

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Aptamer-conjugated nanomaterials for bioanalysis and biotechnology applications

Tao Chen et al.

NANOSCALE (2011)

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PROTEIN-PROTEIN INTERACTIONS Pull-down for single molecules

Philip Tinnefeld

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Probing cellular protein complexes using single-molecule pull-down

Ankur Jain et al.

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Fluorescent probes for sensing and imaging

Tasuku Ueno et al.

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An RNA Aptamer with High Affinity and Broad Specificity for Zinc Finger Proteins

Tristen C. Weiss et al.

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Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models

Chunhua Lu et al.

CANCER BIOLOGY & THERAPY (2010)

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Probing biomolecular interactions using surface enhanced Raman spectroscopy: label-free protein detection using a G-quadruplex DNA aptamer

Michael A. Ochsenkuehn et al.

CHEMICAL COMMUNICATIONS (2010)

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Aptasensors: A Review

Y. C. Lim et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2010)

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Structural Dynamics of Thrombin-Binding DNA Aptamer d(GGTTGGTGTGGTTGG) Quadruplex DNA Studied by Large-Scale Explicit Solvent Simulations

Roman Reshetnikov et al.

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Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure

Karen M. Ruff et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Expanding the Chemistry of DNA for in Vitro Selection

Jonathan D. Vaught et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

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Conformational plasticity of RNA for target recognition as revealed by the 2.15 Å crystal structure of a human IgG-aptamer complex

Yusuke Nomura et al.

NUCLEIC ACIDS RESEARCH (2010)

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Designer DNA Nanoarchitectures

Chenxiang Lin et al.

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A hairpin aptamer-based electrochemical biosensing platform for the sensitive detection of proteins

Zai-Sheng Wu et al.

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Combination of aptamer with gold nanoparticles for electrochemical signal amplification: Application to sensitive detection of platelet-derived growth factor

Jing Wang et al.

BIOSENSORS & BIOELECTRONICS (2009)

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A solid-state electrochemiluminescence biosensing switch for detection of thrombin based on ferrocene-labeled molecular beacon aptamer

Xiaoying Wang et al.

BIOSENSORS & BIOELECTRONICS (2009)

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Electrochemical Aptasensors - Recent Achievements and Perspectives

Tibor Hianik et al.

ELECTROANALYSIS (2009)

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Compounds Binding to the S2-S3 Pockets of Thrombin

Mikael Nilsson et al.

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Global mapping of protein-DNA interactions in vivo by digital genomic footprinting

Jay R. Hesselberth et al.

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Label-free electrochemical aptasensor for the detection of lysozyme

Marcela C. Rodriguez et al.

TALANTA (2009)

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Molecular crowding effects on structure and stability of DNA

Daisuke Miyoshi et al.

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Ultrasensitive colorimetric detection of protein by aptamer - Au nanoparticles conjugates based on a dot-blot assay

Yuling Wang et al.

CHEMICAL COMMUNICATIONS (2008)

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Tunable aptamer capillary electrophoresis and its application to protein analysis

Hongquan Zhang et al.

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Assembling materials with DNA as the guide

Faisal A. Aldaye et al.

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Protein detection with aptamer biosensors

Beate Strehlitz et al.

SENSORS (2008)

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Aptamer-based biosensors

Shiping Song et al.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2008)

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Aptamers:: molecular tools for analytical applications

Teresa Mairal et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2008)

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Controlling cavity reflectivity with a single quantum dot

Dirk Englund et al.

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Solution NMR of supramolecular complexes: providing new insights into function

Remco Sprangers et al.

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Biological recognition patterns implicated by the formation and stability of ternary metal ion complexes of low-molecular-weight formed with amino acid/peptides and nucleobases/nucleosides

Angel Terron et al.

COORDINATION CHEMISTRY REVIEWS (2007)

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Aptamer-based biosensors for label-free voltammetric detection of lysozyme

Alan K. H. Cheng et al.

ANALYTICAL CHEMISTRY (2007)

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Label-free protein biosensor based on aptamer-modified carbon nanotube field-effect transistors

Kenzo Maehashi et al.

ANALYTICAL CHEMISTRY (2007)

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DMS footprinting of structured RNAs and RNA-protein complexes

Pilar Tijerina et al.

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Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions

Lance M. Hellman et al.

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Polyethyleneimine functionalized iron oxide nanoparticles as agents for DNA delivery and transfection

S. C. McBain et al.

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Electronic aptamer-based sensors

Itamar Willner et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)

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Fabrication and characterization of RNA aptamer microarrays for the study of protein-aptamer interactions with SPR imaging

Yuan Li et al.

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DNA tile based self-assembly: Building complex nanoarchitectures

Chenxiang Lin et al.

CHEMPHYSCHEM (2006)

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MolDock: A new technique for high-accuracy molecular docking

Rene Thomsen et al.

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Reagentless, reusable, ultrasensitive electrochemical molecular beacon aptasensor

AE Radi et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)

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The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA

MJ Law et al.

NUCLEIC ACIDS RESEARCH (2006)

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A novel electrochemical detection method for aptamer biosensors

GS Bang et al.

BIOSENSORS & BIOELECTRONICS (2005)

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Comparing protein-ligand docking programs is difficult

JC Cole et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2005)

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Displacement enzyme linked aptamer assay

E Baldrich et al.

ANALYTICAL CHEMISTRY (2005)

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Investigation of molecular beacon aptamer-based bioassay for platelet-derived growth factor detection

MC Vicens et al.

CHEMBIOCHEM (2005)

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Article Biochemistry & Molecular Biology

Effects of fluorescent dyes, quenchers, and dangling ends on DNA duplex stability

BG Moreira et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)

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Article Chemistry, Medicinal

Detection of aptamer-protein interactions using QCM and electrochemical indicator methods

T Hianik et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

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Article Oncology

Nanopartide-aptamer bioconjugates: A new approach for targeting prostate cancer cells

OC Farokhzad et al.

CANCER RESEARCH (2004)

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Article Multidisciplinary Sciences

Crystal structure of NF-κB (p50)2 complexed to a high-affinity RNA aptamer

DB Huang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

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Article Chemistry, Analytical

Specific aptamer-protein interaction studied by atomic force microscopy

YX Jiang et al.

ANALYTICAL CHEMISTRY (2003)

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Article Chemistry, Medicinal

Absorption classification of oral drugs based on molecular surface properties

CAS Bergström et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

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Review Biotechnology & Applied Microbiology

Stem-loop oligonucleotides: a robust tool for molecular biology and biotechnology

NE Broude

TRENDS IN BIOTECHNOLOGY (2002)

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Article Biochemistry & Molecular Biology

Hemin-stimulated docking of cytochrome c to a hemin-DNA aptamer complex

DJF Chinnapen et al.

BIOCHEMISTRY (2002)

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Review Biochemistry & Molecular Biology

A review of protein-small molecule docking methods

RD Taylor et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2002)

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Article Biochemistry & Molecular Biology

In vivo recognition of an RNA aptamer by its transcription factor target

LA Cassiday et al.

BIOCHEMISTRY (2001)

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Article Cell Biology

Molecular beacon aptamer fluoresces in the presence of Tat protein of HIV-1

R Yamamoto et al.

GENES TO CELLS (2000)

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