☆ 4.6 Review

Chemoselective Reactions of Functionalized Sulfonyl Halides

CHEMICAL RECORD (2023)

Related references

Note: Only part of the references are listed.
Article Chemistry, Organic

Discovery of (E)-2-Methoxyethene-1-sulfonyl Fluoride for the Construction of Enaminyl Sulfonyl Fluoride

Min Liu et al.

Summary: A new sulfonyl fluoride reagent (E)-2-methoxye-thene-1-sulfonyl fluoride (MeO-ESF) was developed and successfully applied for the construction of enaminyl sulfonyl fluoride (N-ESF). This protocol provides a highly atom-economical access to diverse N-ESF and produces CH3OH as the sole byproduct under mild and environmentally benign conditions.

JOURNAL OF ORGANIC CHEMISTRY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

EnT-Mediated N-S Bond Homolysis of a Bifunctional Reagent Leading to Aliphatic Sulfonyl Fluorides

Johannes E. Erchinger et al.

Summary: This article presents a new synthetic method that utilizes a photosensitizer to react sulfur fluoride compounds with alkenes, resulting in protected beta-amino sulfonyl fluorides. This method can be used to synthesize peptido sulfonyl fluorides, beta-ammonium sulfonates, and beta-sultams relevant in medicinal chemistry.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2023)

Add to Collection
Article Biochemistry & Molecular Biology

3-(Adenosylthio)benzoic Acid Derivatives as SARS-CoV-2 Nsp14 Methyltransferase Inhibitors

Olga Bobileva et al.

Summary: SARS-CoV-2 nsp14 guanine-N7-methyltransferase is crucial for viral RNA translation, and compound 5p was developed as a potent inhibitor targeting both SAM and mRNA-binding pockets of nsp14. It exhibited subnanomolar inhibitory activity and enhanced cell membrane permeability compared to the parent inhibitor, suggesting its potential as a bisubstrate inhibitor for further development in combating the virus.

MOLECULES (2023)

Add to Collection
Review Chemistry, Organic

Sulfur(vi) fluorides as tools in biomolecular and medicinal chemistry

Sabrina N. Carneiro et al.

Summary: Recent advances in synthesizing sulfur(vi)-fluorides have greatly expanded their application in biomolecular chemistry. This review provides an overview of synthetic strategies for a variety of S(vi) fluorides and discusses their use in chemical biology, bioconjugation, and medicinal chemistry.

ORGANIC & BIOMOLECULAR CHEMISTRY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Insights into structure-property relationships in ionic liquids using cyclic perfluoroalkylsulfonylimides

Younes K. J. Bejaoui et al.

Summary: In this study, room temperature ionic liquids (RTILs) with cyclic sulfonimide anions ncPFSI (ring size: n = 4-6) and various cations [EMIm](+), [BMIm](+), and [BMPL](+) were synthesized. Their solid-state structures were determined by single-crystal X-ray diffraction, and their physicochemical properties were assessed. The influence of the ring size of the cyclic sulfonimide anions on the properties of the ILs was revealed.

CHEMICAL SCIENCE (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Rapid and Scalable Halosulfonylation of Strain-Release Reagents

Helena D. Pickford et al.

Summary: This article reports a one-pot synthesis method for the preparation of sulfonylated non-classical arene bioisosteres. The method is scalable, practical, and conducted under mild conditions. It utilizes in situ reactions of sulfonyl halides generated from readily available sulfinate salts and halogen atom sources, resulting in the synthesis of a diverse range of compounds relevant to pharmaceutical and agrochemical applications.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Chemical and biology of sulfur fluoride exchange (SuFEx) click chemistry for drug discovery

Shadrack Wilson Lucas et al.

Summary: Compounds containing an S-F bond have attracted great attention in the chemical and biological literature. Sulfonyl fluorides, in particular, are widely used as covalent protein inhibitors and biological probes. The introduction of fluorine atom in drugs has led to improved medicinal properties and revolutionized pharmaceutical development. Sulfonyl fluoride functional group is widely adopted in chemical biology due to its unique balance between reactivity and stability under physiological conditions. Recent developments of sulfonyl fluoride-based compounds have shown potential in various therapeutic applications.

BIOORGANIC CHEMISTRY (2023)

Add to Collection
Article Chemistry, Organic

Hemin-Promoted Direct C-H Thiolation in the Synthesis of Diaryl Sulfides

Bao Li et al.

Summary: Herein, we report a new method for direct preparation of diphenyl sulfides using P-toluenesulfonyl chloride as an effective thiophenyl radical precursor with assistance from Hemin. Various substituted anisoles and benzenesulfonyl chlorides are well tolerated, resulting in moderate to good yields of diaryl sulfides. The potential of the proposed method is validated by good yields obtained in gram scale reactions.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2023)

Add to Collection
Article Chemistry, Organic

Expanding the Chemical Space of 1,2-Difunctionalized Cyclobutanes

Anton V. Chernykh et al.

Summary: An efficient method is described for the synthesis of previously unavailable or hardly accessible 1,2-difunctionalized cyclobutanes using a divergent strategy. These compounds are important building blocks for medicinal chemistry and were prepared as racemic and single enantiomers. The developed procedures can be easily scaled up to obtain the target compounds on a large scale. Structural characterization of the 1,2-difunctionalized cyclobutane core was performed using X-ray diffraction experiments and extended Cremer-Pople puckering parameters and exit vector (EVP) plots.

JOURNAL OF ORGANIC CHEMISTRY (2023)

Add to Collection
Article Chemistry, Organic

Synthesis of Pyrazolo[1,5-a]pyridinyl, Pyrazolo[1,5-a]quinolinyl, and Pyrazolo[5,1-a]isoquinolinyl Sulfonyl Fluorides via a [3+2] Annulation

Wen-Qian Wu et al.

Summary: A [3 + 2] cycloaddition reaction of N-amino pyridines, N-aminoquinolines, and N-aminoisoquinolines with 1-bromoethene-1-sulfonyl fluoride (BESF) was conducted to obtain pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]quinolinyl, and pyrazolo[5,1-a]isoquinolinyl sulfonyl fluorides with good yields (43-90%). This transformation process exhibits broad substrate specificity, mild reaction conditions, and operational simplicity. Therefore, it has significant value in the field of medicinal chemistry and other disciplines.

JOURNAL OF ORGANIC CHEMISTRY (2023)

Add to Collection
Article Chemistry, Organic

Alkyl Sulfonyl Fluorides Incorporating Geminal Dithioesters as SuFEx Click Hubs via Water-Accelerated Organosuperbase Catalysis

Jin Hyun Park et al.

Summary: In this study, a new efficient method for synthesizing alkyl sulfonyl fluorides incorporating gamma-geminal dithioester via phosphazene catalysis is reported. The aqueous, neutral organosuperbase catalytic system amplifies reactivity through hydrophobic amplification. The synthesized alkyl sulfonyl fluorides are applicable for click connection of bioactive molecules.

ORGANIC LETTERS (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction

Jian Ding et al.

Summary: WD repeat domain 5 (WDR5), a member of the WD40-repeat protein family, is crucial in multiple processes and is targeted for pharmacological inhibition in diseases such as cancer and neurodegenerative disorders. Interactions between WDR5 and its partners are vital for its function. Researchers have discovered new WDR5 inhibitors that target a different binding site on this protein, providing potential therapeutic strategies by disrupting the interaction with its partner MYC.

ACS CHEMICAL BIOLOGY (2023)

Add to Collection
Article Biochemistry & Molecular Biology

Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors

Yuting Chen et al.

Summary: This study describes a novel nucleoside derivative as a potent PRMT5 inhibitor, which shows strong inhibitory effects on malignant tumor cells and arrests cell proliferation by inducing apoptosis.

BIOORGANIC CHEMISTRY (2023)

Add to Collection
Article Chemistry, Multidisciplinary

Accelerated SuFEx Click Chemistry For Modular Synthesis**

Christopher J. Smedley et al.

Summary: Accelerated SuFEx click chemistry (ASCC) is an improved method for efficient and catalytic coupling of aryl and alkyl alcohols with various SuFExable hubs. The powerful combination of BTMG and HMDS reagents allows for lower catalyst loadings, providing a scalable method that is safe, efficient, and practical for modular synthesis. ASSC expands the accessibility of SuFEx products and will have significant applications in organic synthesis, medicinal chemistry, chemical biology, and materials science.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Radical 1-Fluorosulfonyl-2-alkynylation of Unactivated Alkenes

Nils Lennart Frye et al.

Summary: In this study, a transition-metal-free radical 1,2-difunctionalization method was developed to access beta-alkynyl-fluorosulfonylalkanes. The obtained compounds could be diversified into sulfonates and sulfonamides using SuFEx click chemistry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Multiplexed Small-Molecule-Ligand Binding Assays by Affinity Labeling and DNA Sequence Analysis**

Bo Cai et al.

Summary: A novel assay method combining DNA encoding with split-and-pool sample handling is developed to improve small-molecule binding assays to target proteins. The approach involves affinity labeling of DNA-linked ligands to a protein target, allowing for quantification of DNA barcodes to detect ligand binding. This method demonstrates potential utility in high-throughput small-molecule screening.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Review Chemistry, Organic

Mechanistic studies of the solvolysis of alkanesulfonyl and arenesulfonyl halides

Malcolm J. D'Souza et al.

Summary: This article reviews several studies on the solvolysis mechanisms of alkanesulfonyl chlorides and arenesulfonyl chlorides. The use of the extended Grunwald-Winstein equation and kinetic solvent isotope effects in studying solvolysis reactions is emphasized. There is also a discussion on other sulfur(VI) substrates such as anhydrides, sulfamoyl chlorides, and chlorosulfate esters, which will be the topics of future research.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Progress in the Electrochemical Reactions of Sulfonyl Compounds

Wangsheng Liu et al.

Summary: Electrosynthesis has gained more attention recently for its potential in replacing chemical oxidants or reductants in molecule-electrode electron transfer. Sulfonyl compounds have been found as practical precursors of several radicals, and electrochemical redox reactions offer green and efficient pathways for activating these compounds.

CHEMSUSCHEM (2022)

Add to Collection
Article Chemistry, Organic

SuFExable NH-Pyrazoles via 1,3-Dipolar Cycloadditions of Diazo Compounds with Bromoethenylsulfonyl Fluoride

Pavel Yamanushkin et al.

Summary: This study presents a facile strategy to synthesize SuFExable NH-pyrazoles via strain and catalyst-free 1,3-dipolar cycloadditions of stabilized diazo compounds under mild conditions. Subsequent SuFEx reactions can efficiently proceed with various N- and O-nucleophiles. The access to SuFExable NH-pyrazoles, which contain two common pharmacophores, opens up new opportunities in drug discovery, chemical biology, materials chemistry, and related fields.

JOURNAL OF ORGANIC CHEMISTRY (2022)

Add to Collection
Review Chemistry, Organic

Recent Advances in the Chemistry and Biological Activity of Sulfonamide Derivatives

Mahmoud N. M. Yousif et al.

Summary: This review presents different synthetic methods for the preparation of sulfonamides and summarizes the biological activities of sulfonamides, such as antibacterial, anticancer, and enzyme inhibitory activities. The synthesis of sulfonamides involves reacting sulfonyl chloride derivative and amino derivative in alkaline media. Sulfonamides exhibit various pharmacological activities due to the involvement of different functional groups in the compound.

MINI-REVIEWS IN ORGANIC CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Amino-oxetanes as amide isosteres by an alternative defluorosulfonylative coupling of sulfonyl fluorides

Juan J. Rojas et al.

Summary: Bioisosteres offer valuable design elements for adjusting the structural and pharmacokinetic characteristics of bioactive compounds. This study explores the potential of aryl oxetane amines as bioisosteres for benzamides, and presents a novel reaction pathway for the synthesis of amino-oxetanes using sulfonyl fluorides. The reaction is compatible with various polar functionalities and can be applied to existing amine libraries. Computational and kinetic studies support the formation of an oxetane carbocation as the rate-determining step in the reaction.

NATURE CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

'Awaken' aryl sulfonyl fluoride: a new partner in the Suzuki-Miyaura coupling reaction

Guofu Zhang et al.

Summary: This study describes the activation of the traditionally stable -SO2F group using a novel partner in the Suzuki-Miyaura coupling reaction. The catalytic system of Pd(OAc)(2) and Ruphos ligands achieved good yields and broad functional group compatibility. The approach's synthetic utility was further highlighted by the sequential synthesis of non-symmetric terphenyls and the gram grade process.

NEW JOURNAL OF CHEMISTRY (2022)

Add to Collection
Article Chemistry, Organic

Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group

Hinano Takemura et al.

Summary: This study discloses assembling methods using 2-azidoacrylamides with a nucleophilic amino group. Divergent transformations of the amine-type trivalent platform resulted in a wide range of 2-azidoacrylamides involving a fluorosulfonyl group. Consecutive click conjugations, including triazole formation, thiol-ene-type 1,4-addition, and SuFEx reactions, efficiently assembled easily available simple modules.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

Add to Collection
Article Chemistry, Organic

Synergistic Effect of Squaric Acid in Bromine-Catalyzed Deoxygenation of Sulfonyl Derivatives: Mechanistic Investigations and Synthetic Applications in Electrophilic (Fluoroalkyl)sulfenylation

Haonan Xiang et al.

Summary: A method for electrophilic (fluoroalkyl) sulfenylation of nucleophiles through the collaborative use of CTAB and squaric acid to promote deoxygenation of sulfonyl derivatives is reported. Mechanistic studies show that squaric acid significantly reduces the energy barrier in the first step of deoxygenation. This novel method allows for the reduction of a wide range of functionalized sulfonyl chlorides and sulfonic anhydrides and demonstrates a high tolerance to various functional groups.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Chemoselective Reduction of Tertiary Amides by 1,3-Diphenyl-disiloxane (DPDS)

Travis A. Hammerstad et al.

Summary: A convenient method for chemoselective reduction of tertiary amides at room temperature has been developed. The method tolerates various functional groups and offers mild conditions and broad applicability.

SYNTHESIS-STUTTGART (2022)

Add to Collection
Article Materials Science, Biomaterials

A novel Y-shaped photoiniferter used for the construction of polydimethylsiloxane surfaces with antibacterial and antifouling properties

Wei Sun et al.

Summary: This study successfully introduced antibacterial and antifouling functionalities onto PDMS surfaces simultaneously using a novel Y-shaped asymmetric dual-functional photoiniferter. Experimental results demonstrated excellent antibacterial and antifouling properties of the modified surfaces, with maintained cytocompatibility. The strategy presented in this study shows simplicity and convenience, providing inspiration for the construction of diverse dual-functional surfaces utilizing PDMS more effectively.

JOURNAL OF MATERIALS CHEMISTRY B (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Sulfonyl fluorides as targets and substrates in the development of new synthetic methods

Terry Shing-Bong Lou et al.

Summary: The advent of sulfur(VI)-fluoride exchange (SuFEx) processes has led to research into electrophilic species featuring a sulfur-fluorine bond. Sulfonyl fluorides, known for their reactivity and stability, have been extensively studied for their applications in medicinal chemistry and chemical biology. Various synthetic approaches, starting from sulfur-containing and non-sulfur-containing substrates, have been developed. This review provides an overview of the challenges and progress in the synthesis and manipulation of sulfonyl fluorides.

NATURE REVIEWS CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Cell-Active, Reversible, and Irreversible Covalent Inhibitors That Selectively Target the Catalytic Lysine of BCR-ABL Kinase

Peng Chen et al.

Summary: This study presents a general approach to develop cell-active covalent inhibitors of protein kinases by targeting the conserved catalytic lysine residue using key SuFEx and salicylaldehyde-based imine chemistries. The strategy was validated by successfully developing covalent inhibitors against BCR-ABL kinase, which showed high selectivity and potency. The salicylaldehyde-containing A5 compound is the first reversible covalent ABL inhibitor with prolonged residence time and minimal off-target effects.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Chemistry, Medicinal

Development of BRD4 inhibitors as anti-inflammatory agents and antidotes for arsenicals

Marina Fosso Yatchang et al.

Summary: Arsenicals, a class of highly reactive and toxic chemical warfare agents, cause robust inflammatory response and systemic organ damage. Developing suitable antidotes, such as small molecule inhibitors of BRD4, is of great importance to block injury caused by exposure to arsenicals.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Time and Atom Economical Regio- and Chemoselective Radical Cyclization of Unactivated 1,6-Enynes Under Metal- and Oxidant-Free Conditions

Mohana Reddy Mutra et al.

Summary: In this study, time-atom economic regio- and chemoselective sulfonyl radical triggered 5-exo-dig cyclization of unactivated 1,6-enynes with sulfonyl halides was developed under metal, additive-free reaction conditions to obtain highly substituted five-membered heterocyclic compounds. This transformation involves the formation of three new bonds, including C-SO2, C-C, and active C-I/Br bonds. Importantly, the one-pot protocols allow for direct synthesis of desired products from sodium sulfinates and have additional advantages such as reducing chemical waste, saving time, and simplifying practical aspects compared to existing protocols.

CHEMISTRY-A EUROPEAN JOURNAL (2022)

Add to Collection
Article Chemistry, Organic

Catalytic Decarboxylative Fluorosulfonylation Enabled by Energy-Transfer-Mediated Photocatalysis

Zhi-Da Chen et al.

Summary: This catalytic decarboxylative fluorosulfonylation approach efficiently converts abundant aliphatic carboxylic acids to sulfonyl fluorides with high functional group tolerance under mild conditions, providing a valuable synthetic strategy.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Olefination with Sulfonyl Halides and Esters: Synthesis of Unsaturated Sulfonyl Fluorides

Michal Tryniszewski et al.

Summary: Methanedisulfonyl fluoride can convert aromatic aldehydes into useful substrates and mimic the mechanism of Horner-Wadsworth-Emmons olefination. In the absence of base, electron-rich aldehydes can also undergo Knoevenagel condensation to yield unsaturated 1,1-disulfonyl fluorides. Additionally, elusive ethene-1,1-disulfonyl fluoride can be trapped with 4-(dimethylamino)pyridine to form a zwitterionic adduct as characterized by X-ray studies.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Electrochemical Synthesis of β-Keto Sulfonyl Fluorides via Radical Fluorosulfonylation of Vinyl Triflates

Qingyuan Feng et al.

Summary: Versatile beta-keto sulfonyl fluorides can be synthesized by electrochemical methods using inexpensive graphite felt as electrodes, without the need for metal catalysts. This protocol offers a mild and scalable approach to access valuable compounds from readily available precursors, including cyclic ones that were previously difficult to obtain.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Ruthenium(II)-Catalyzed Chelation-Assisted Desulfitative Arylation of Benzo[h]quinolines with Arylsulfonyl Chlorides

Yi-Xin Xu et al.

Summary: A novel chelation-assisted C-H arylation reaction of benzo[h]quinoline is described in this study. The reaction, using [RuCl2(p-cymene)]2 as the catalyst and cheap and easily accessible arylsulfonyl chlorides as the arylation source, exhibits simple reaction conditions, a broad substrate scope, and good functional group tolerance. The successful application of bioactive-molecule-based sulfonyl chlorides further emphasizes the potential utility and importance of this desulfitative C-H arylation protocol.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Synthesis of Tetrasubstituted Allenes via Visible-Light-Promoted Radical 1,3-Difunctionalization of Alkynyl Diazo Compounds

Weiyu Li et al.

Summary: In this study, an unprecedented process of generating allenyl radicals through radical addition and 1,2-radical shift was described. This process was successfully applied to the 1,3-difunctionalization of alkynyl diazo compounds, allowing the synthesis of tetrasubstituted allenes. The reactions were carried out under visible light without the need for photocatalysts or additives.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Boron-Promoted Umpolung Reaction of Sulfonyl Chlorides for the Stereospecific Synthesis of Thioglycosides via Reductive Deoxygenation Coupling Reactions

Siyu Li et al.

Summary: In this study, we disclosed an efficient method for the stereospecific synthesis of 1-thioglycosides via a boron-promoted reductive deoxygenation coupling reaction from readily accessible sulfonyl chlorides and glycosyl bromides. Our protocol features mild conditions, excellent functional group tolerance, and stereoselectivity. The translational potential of this metal-free approach is demonstrated by the late-stage glycodiversification of natural products and drug molecules.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Regio- and Stereoselective Installation of Bromide onto Vinyl Sulfonyl Fluorides: Construction of a Class of Versatile Sulfur Fluoride Exchange Hubs

Xu Zhang et al.

Summary: A convenient protocol was developed for the regio- and stereoselective installation of a bromine atom on 2-arylvinylsulfonyl fluorides, providing versatile Z-BASF molecules in high yields. These Z-BASF molecules displayed various reactivities in chemical transformations.

ORGANIC LETTERS (2022)

Add to Collection
Article Chemistry, Organic

Rhodium-Catalyzed Vinyl Sulfonylation of 3-Carbonyl-Substituted Indoles with Ethenesulfonyl Fluoride by Cross-Dehydrogenative Coupling: An Application in (3+2) Cycloaddition

K. Sandeep et al.

Summary: A Rh(III)-catalyzed site-selective vinyl sulfonylation of indoles with ethenesulfonyl fluoride (ESF) by a carbonyl oxygen-directed method has been reported. This selective reaction strategy delivers the corresponding cross-dehydrogenative coupled products between indoles and ESF in high yields and with high selectivity, demonstrating good functional group tolerance. Furthermore, the developed synthetic route has shown potential in the synthesis of triazoles through a thermal (3+2) cycloaddition reaction in the absence of a metal catalyst.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Radical Hydro-Fluorosulfonylation of Unactivated Alkenes and Alkynes

Peng Wang et al.

Summary: A new method based on radical fluorosulfonylation has been developed for the synthesis of aliphatic sulfonyl fluorides from unactivated alkenes. This method can be applied to the late-stage modifications of natural products and peptides, as well as drug ligation.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Chemistry, Organic

A General Procedure for the Construction of 2-Alkyl-Substituted Vinyl Sulfonyl Fluoride

Xu Zhang et al.

Summary: A series of compact and multifunctional 2-alkyl-substituted vinyl sulfonyl fluorides were efficiently synthesized using alkyl iodides and 2-chloroprop-2-ene-1-sulfonyl fluoride (CESF) through a Giese-type radical approach. This method offers a new and general route for the synthesis of alkenyl sulfonyl fluorides, including structures that were previously challenging to obtain, and allows for a wide range of derivatization reactions.

ORGANIC LETTERS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Tailored Phenyl Esters Inhibit ClpXP and Attenuate Staphylococcus aureus α-Hemolysin Secretion

Markus Schwarz et al.

Summary: Researchers have developed novel inhibitors that can effectively attenuate the virulence of multidrug-resistant bacteria by manipulating the stability and inhibitory potency of phenyl ester ClpXP inhibitors. These inhibitors show promising results in inhibiting the activity of key contributors to bacterial virulence, such as Staphylococcus aureus, without exhibiting significant cytotoxicity against human and bacterial cells.

CHEMBIOCHEM (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Hydrophobic Amplification Enabled High-Turnover Phosphazene Superbase Catalysis

Sun Bu Lee et al.

Summary: Beta-Sulfido sulfonyl fluoride and its derivatives have gained attention in medicinal chemistry and material science. A direct establishment of such chemical structures remains challenging, motivating the development of an efficient catalytic approach. This study achieved a high-turnover catalytic thia-Michael addition, leading to the production of unprecedented beta-arylated-beta-sulfido sulfonyl fluorides.

CHEMSUSCHEM (2022)

Add to Collection
Article Chemistry, Multidisciplinary

β-Aminosulfonyl Fluorides via Water-Accelerated N-Heterocyclic Carbene Catalysis

Jin Hyun Park et al.

Summary: A water-accelerated, N-heterocyclic carbene (NHC)-catalyzed aza-Michael addition reaction was reported for the synthesis of beta-aminosulfonyl fluorides, key components of the SuFEx reaction. Water as a reaction medium significantly enhanced the reaction rate and demonstrated late-stage ligation with bioactive molecules.

CHEMSUSCHEM (2022)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Calcium Bistriflimide-Mediated Sulfur(VI)-Fluoride Exchange (SuFEx): Mechanistic Insights toward Instigating Catalysis

Brian Han et al.

Summary: In this study, we investigated the mechanistic aspects of the sulfur(VI)-fluoride exchange (SuFEx) between sulfonyl fluorides and amines mediated by calcium bistriflimide. We determined the likely pre-activation resting state and calculated the SuFEx activation barrier. Transition state analysis revealed the effects of calcium-substrate contact and additive on the reaction. Stable Ca-F complexes inhibited catalytic turnover, but a proof-of-principle redesign showed that sulfonamide formation is still feasible.

INORGANIC CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Dicarbofunctionalization of [1.1.1]Propellane Enabled by Nickel/Photoredox Dual Catalysis: One-Step Multicomponent Strategy for the Synthesis of BCP-Aryl Derivatives

Weichen Huang et al.

Summary: Bicyclo[1.1.1]pentane (BCP) motifs have become important in pharmaceutical, agrochemical, and materials chemistry. Most of these structures are obtained through the cleavage of the internal C-C bond in [1.1.1]propellane, using either radicals or metal-based nucleophiles. A multicomponent reaction that allows direct access to complex and diverse disubstituted BCP products is more attractive than current stepwise approaches.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Irreversible Antagonists for the Adenosine A2B Receptor

Ahmed Temirak et al.

Summary: In this study, a series of irreversible A(2B)AR antagonists based on an 8-p-sulfophenylxanthine scaffold were designed and synthesized. Among them, p-(1-propylxanthin-8-yl)benzene sulfonyl fluoride (6a, PSB-21500) was identified as the most potent and selective antagonist. However, these irreversible antagonists did not interact with K269 (7.32) as previously speculated.

MOLECULES (2022)

Add to Collection
Article Chemistry, Organic

(3+2) Cycloadditions of Vinyl Sulfonyl Fluorides with Ethyl Diazo-acetate or Azides: Metal-Free Synthesis of Pyrazole and Triazole Scaffolds via SO2 Elimination

K. Sandeep et al.

Summary: A new reaction method for the rapid construction of pyrazole or triazole cores via Michael addition and SO2 gas elimination has been developed. Trimethylsilyl azide or organic azide can selectively attack the beta-carbon of vinyl sulfonyl fluoride, generating different substituted triazoles.

SYNTHESIS-STUTTGART (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase

Julie E. Bolding et al.

Summary: This study demonstrates the use of aryl fluorosulfate electrophiles as covalent inhibitors targeting SIRT5, providing a potential avenue for the development of drug candidates.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

Add to Collection
Article Biochemistry & Molecular Biology

MicroRNA detection in biologically relevant media using a split aptamer platform

Liming Wang et al.

Summary: This study presents a rapid method for developing aptamer-based fluorescent biosensors that can specifically detect miRNAs. The method is applicable to complex biological environments and requires minimal sample handling.

BIOORGANIC & MEDICINAL CHEMISTRY (2022)

Add to Collection
Article Chemistry, Medicinal

Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators

Leda Ivanova Bencheva et al.

Summary: A novel series of SBA-derived CAM with high antiviral activity against HBV replication in CHB patients has been discovered, with compound 10 showing excellent pharmacokinetics in mice and dose-dependent reduction of viral replication. This new SBA CAM offers hope for the development of anti-HBV therapies.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

Add to Collection
Article Chemistry, Medicinal

Targeting non-alcoholic fatty liver disease: Design, X-ray co-crystal structure and synthesis of 'first-in-kind' inhibitors of serine/threonine kinase25

Scarlett Kiyeleko et al.

Summary: We describe the synthesis of a series of 3-t-butyl 5-aminopyrazole p-substituted arylamides as inhibitors of the enzyme STK25, which is implicated in the progression of NAFLD. One of the inhibitors, with a p-N-pyrrolidinosulphonamide group, exhibited IC50 = 228 nM. The interactions between the inhibitor and STK25 were confirmed by co-crystal structure and molecular docking. A new series of triazolo dihydro oxazine carboxamides of 3-t-butyl 5-aminopyrazole showed no activity against STK25.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Design, synthesis and biological evaluation of novel dihydrobenzodioxine derivatives as HBV capsid protein inhibitors

Linyue Liu et al.

Summary: Capsid assembly modulators (CAMs) have been proven effective in blocking HBV replication. Among them, sulfonamides (NVR 3-778 and BA-38017) show promising antiviral activity with reduced cytotoxicity. In this study, three series of compounds were synthesized and evaluated for their anti-HBV activity.

BIOORGANIC CHEMISTRY (2022)

Add to Collection
Article Chemistry, Medicinal

Discovery of Benzo[d]imidazole-6-sulfonamides as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the First Bromodomain

Alessandra Cipriano et al.

Summary: In this study, a series of benzimidazole-6-sulfonamide compounds were designed and synthesized, which selectively target the first bromodomain (BD1) of BET family proteins. The most promising compound showed good binding potency, improved metabolic stability, and selectivity towards BD1.

CHEMMEDCHEM (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Metal-Free Multicomponent Strategy for Amidine Synthesis

Zayed Alassad et al.

Summary: Amidines are bioactive compounds widely used in various natural products. This study presents a metal-free multicomponent strategy for the synthesis of amidines and successfully synthesizes a biologically active compound.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Discovery of Novel Boron-Containing N-Substituted Oseltamivir Derivatives as Anti-Influenza A Virus Agents for Overcoming N1-H274Y Oseltamivir-Resistant

Ruifang Jia et al.

Summary: Novel boron-containing derivatives were designed and synthesized to address drug resistance to influenza virus. Compound 2c exhibited strong antiviral activity against multiple influenza viruses, low cytotoxicity, and no acute toxicity.

MOLECULES (2022)

Add to Collection
Article Multidisciplinary Sciences

Diversity oriented clicking delivers ?-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors br

Yunfei Cheng et al.

Summary: Diversity Oriented Clicking (DOC) is a method for rapidly synthesizing functional libraries by combining classical and modern click chemistries. It involves modulating the assembly of compounds through chemical diversification of core SuFExable hubs, such as 2-Substituted-Alkynyl-1-Sulfonyl Fluorides (SASFs). The stereoselective Michael-type addition reactions from SASF hubs, including reactions with secondary amines, carboxylates, 1H-1,2,3-triazole, and halides, provide high yielding beta-substituted alkenyl sulfonyl fluorides as single isomers with minimal purification. These compounds show potential as covalent inhibitors of human neutrophil elastase, demonstrating the biological function aspect of click chemistry.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Add to Collection
Article Biochemistry & Molecular Biology

Design, synthesis and biological evaluation of 2-aminopyridine derivatives as USP7 inhibitors

Xiaoming Xu et al.

Summary: A series of novel 2-aminopyridine derivatives were synthesized and evaluated for their USP7 inhibitory activities. Compounds 7 and 21 showed significant binding interactions with USP7 according to surface plasmon resonance binding assay.

BIOORGANIC CHEMISTRY (2022)

Add to Collection
Article Chemistry, Organic

A reductive dehalogenative process for chemo- and stereoselective synthesis of 1,3-dienylsulfonyl fluorides

Yu-Zhen Zeng et al.

Summary: A mild and efficient method for the synthesis of 1,3-dienylsulfonyl fluorides was developed via dehalogenation of alpha-halo-1,3-dienylsulfonyl fluorides using zinc powder and acetic acid. Exclusive chemo- and stereoselectivities were achieved. This protocol was successfully applied to the synthesis of heterocyclic dienylsulfonyl fluorides and polyene sulfonyl fluoride.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

Add to Collection
Article Chemistry, Multidisciplinary

Palladium-catalyzed C-H olefination of uridine, deoxyuridine, uridine monophosphate and uridine analogues

Qin Zhao et al.

Summary: The palladium-catalyzed oxidative C-H olefinations of uridine, deoxyuridine, uridine monophosphate and uridine analogues are reported. This protocol offers an efficient, atom-economic, and environmentally friendly approach for synthesizing biologically important C5-alkene modified uracil/uridine-containing derivatives and pharmaceutical candidates.

RSC ADVANCES (2022)

Add to Collection
Review Chemistry, Multidisciplinary

Copper-photocatalyzed ATRA reactions: concepts, applications, and opportunities

Sebastian Engl et al.

Summary: Atom transfer radical addition (ATRA) reactions are important transformations in synthetic chemistry for the difunctionalization of alkenes using simple starting materials. The recent advancement in photocatalysis, particularly using copper complexes, has provided a mild and energy-efficient alternative to the traditional methods that required toxic initiators or harsh thermal conditions. Copper photocatalysis has the advantage of enabling ligand exchange and facilitating transformations utilizing their coordination sphere. It also allows the access to two-component and three-component ATRA reactions that were not feasible with other catalysts like ruthenium or iridium. This review highlights the emerging field of using Cu(i)-substrate assemblies as active photocatalysts for achieving three-component coupling reactions under enantioselective control.

CHEMICAL SOCIETY REVIEWS (2022)

Add to Collection
Article Chemistry, Organic

Regioselective conjugate addition of isoxazol-5-ones to ethenesulfonyl fluoride

Dong-yu Zhu et al.

Summary: A highly regioselective conjugate addition of isoxazol-5-ones to ethenesulfonyl fluoride (ESF) has been developed, yielding N2-alkylated and C4-alkylated isoxazol-5-ones with a sulfonyl fluoride group. Further transformations with amines and phenol give sulfonamides and sulfonates, providing valuable products for drug discovery.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

Add to Collection
Article Chemistry, Organic

A cascade reaction for regiosetective construction of pyrazole-containing aliphatic sulfonyl fluorides

Wen-Fei Yang et al.

Summary: A copper-catalyzed cascade reaction has been developed for the synthesis of highly functionalized pyrazolyl aliphatic sulfonyl fluorides in good yields. This method demonstrates broad substrate compatibility, exclusive regioselectivity, high atom economy, and operational simplicity, making it valuable for the direct construction of pyrazole-containing aliphatic sulfonyl fluorides in medicinal chemistry and related disciplines.

ORGANIC & BIOMOLECULAR CHEMISTRY (2022)

Add to Collection
Article Chemistry, Medicinal

Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis

Nara Liessi et al.

Summary: Cystic fibrosis is a common genetic disorder caused by mutations in the CFTR protein. Some aminoarylthiazoles have been identified as correctors and potentiators for CFTR, with compounds 2 and 13 showing promise for future development as potentiators for chloride transport defects in cystic fibrosis.

MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Electrochemical Oxo-Fluorosulfonylation of Alkynes under Air: Facile Access to β-Keto Sulfonyl Fluorides

Dengfeng Chen et al.

Summary: This study reports a new electrochemical method for generating FSO2 radicals and synthesizing beta-keto sulfonyl fluorides, which can yield two different products through oxo-fluorosulfonylation. These products can be used as building blocks for various derivatives and heterocycles, exhibiting potent activities against Bursaphelenchus xylophilus and Colletotrichum gloeosporioides.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Desulfonative Suzuki-Miyaura Coupling of Sulfonyl Fluorides

Paul Chatelain et al.

Summary: Sulfonyl fluorides have been identified as powerful click electrophiles for Pd-catalyzed Suzuki-Miyaura cross-coupling, occurring selectively in the absence of base and even in the presence of strong acids. Mechanistic experiments and DFT calculations suggest that oxidative addition at the C-S bond followed by desulfonation facilitate transmetalation in this desulfonative cross-coupling reaction.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

A Broad-Spectrum Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates**

Mingjie Wei et al.

Summary: A catalytic method has been developed for the synthesis of sulfonamides and sulfamates with the activation by 1-hydroxybenzotriazole (HOBt) and silicon additives, showing high efficiency for sterically hindered substrates. The catalyst loading is low and yields are generally excellent, demonstrating potential applications in medicinal chemistry.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Iminoboronates as Dual-Purpose Linkers in Chemical Probe Development

Antonie J. van der Zouwen et al.

Summary: Chemical probes that covalently modify proteins are powerful tools for biological research. Choosing the right reactive group for the design of a probe is crucial, and a modular approach has been developed in this study for easy coupling of reactive groups to ligands. The iminoboronate probes synthesized in this study selectively label target proteins and can be further modified using transimination reactions with aminohydrazides, for example, to introduce fluorophores.

CHEMISTRY-A EUROPEAN JOURNAL (2021)

Add to Collection
Article Chemistry, Organic

I2-Promoted Direct C-H Sulfenylation of Isoquinolin-1(2H)-ones with Sulfonyl Chlorides

Cai-Yun Yang et al.

Summary: A simple, efficient, and green method for regioselective C-4 sulfenylation of isoquinolin-1(2H)-ones was described using aryl sulfonyl chlorides as the sulfur source under metal- and solvent-free conditions. The reaction showed high regioselectivity, broad substrate scope, and good functional group tolerance, and a radical reaction mechanism involving ArS. radicals as key intermediates was proposed.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection
Article Chemistry, Medicinal

Discovery of GLPG2451, a Novel Once Daily Potentiator for the Treatment of Cystic Fibrosis

Steven E. Van der Plas et al.

Summary: Cystic fibrosis is a life-threatening disease caused by mutations in the CFTR gene, but its function can be partially restored with correctors and potentiators. The discovery and optimization of a novel potentiator series focused on retaining different intramolecular contacts to identify a series devoid of genotoxic liabilities. The clinical candidate GLPG2451 was chosen based on its pharmacokinetic properties and low CYP induction potential.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Organic

The synthesis of chiral β-naphthyl-β-sulfanyl ketones via enantioselective sulfa-Michael reaction in the presence of a bifunctional cinchona/sulfonamide organocatalyst

Deniz Tozendemir et al.

Summary: Cinchona alkaloid-derived organocatalysts have been widely utilized in asymmetric transformations, resulting in products with high enantiopurity. A bifunctional quinine-derived sulfonamide organocatalyst was developed for catalyzing the asymmetric sulfa-Michael reaction, achieving high enantioselectivity with low catalyst loading. The enriched sulfa-Michael addition products were successfully oxidized to obtain the corresponding sulfones.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Design, synthesis, spectral characterization and molecular docking studies of novel pyranoquinolinyl dihydropyridine carboxylates as potential antibacterial agents including Vibrio cholerae with minimal cytotoxity towards fibroblast cell line (L-929)

G. Lavanya et al.

Summary: Novel pyranoquinolinyl dihydropyridine carboxylate (PDC) derivatives with potential antibacterial activity were designed and synthesized, showing good in vitro antibacterial activity and molecular docking mechanism. The study highlights the potential antimicrobial properties of the PDC derivatives.

BIOORGANIC CHEMISTRY (2021)

Add to Collection
Article Chemistry, Organic

Highly Enantioselective Addition of N-2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride

Jie Chen et al.

Summary: An enantioselective Michael addition has been developed for the synthesis of structurally diverse isatin-derived alpha-(trifluoromethyl)imine derivatives with excellent yields and enantioselectivities, which are valuable candidates for drug discovery.

JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection
Article Chemistry, Organic

Acetal Addition to Electron-Deficient Alkenes with Hydrogen Atom Transfer as a Radical Chain Propagation Step

Wei Chuen Chan et al.

Summary: In this study, a visible-light-promoted addition reaction utilizing a hydrogen atom and an acetal carbon towards various electron-deficient alkenes was described. The reaction operates via a radical chain mechanism, which is a less commonly observed pathway for this type of transformation. Experimental and density functional theory studies confirmed the hydrogen atom transfer from 1,3-dioxolane to alpha-malonyl radicals.

JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Design, synthesis, and antibacterial activity of novel myricetin derivatives containing sulfonate

Shijun Su et al.

Summary: A series of myricetin derivatives containing sulfonate groups were designed and synthesized, showing significant antibacterial activities against various plant pathogenic bacteria. Some compounds demonstrated better activities than commercial reagents, suggesting their potential as new antibacterial agents.

MONATSHEFTE FUR CHEMIE (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2

Emmanuel K. Toroitich et al.

Summary: The study demonstrated the potential of SuTEx compounds in covalent modification of protein tyrosine sites and identified HHS-0701 as a cell-active inhibitor targeting prostaglandin reductase 2.

CHEMBIOCHEM (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Cu-catalyzed endo-selective asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethenesulfonyl fluorides: Efficient access to chiral pyrrolidine-3-sulfonyl fluorides

Yi-Nan Li et al.

Summary: The Cu-catalyzed endo-selective asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethenesulfonyl fluorides (ESFs) provides an efficient method to access a wide range of chiral pyrrolidine-3-sulfonyl fluorides and other chiral sulfonyl derivatives with good yields and stereoselectivity, demonstrating their synthetic utility in SuFEx chemistry.

CHINESE CHEMICAL LETTERS (2021)

Add to Collection
Article Chemistry, Organic

Heteroaliphatic Dimethylphosphine Oxide Building Blocks: Synthesis and Physico-Chemical Properties

Andrii Fedyk et al.

Summary: The scalable synthesis of saturated heterocyclic dimethyl phosphine oxides was achieved through key steps involving reactions of HP(O)Me-2, palladium-catalyzed reactions, and base-mediated nucleophilic substitutions. Introduction of the P(O)Me-2 group significantly affected the compound's basicity, hydrophilicity, and aqueous solubility. This method shows potential for generating lead-like three-dimensional compound libraries as confirmed using the LLAMA tool.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection
Review Chemistry, Organic

Emerging Building Blocks for Medicinal Chemistry: Recent Synthetic Advances

Oleksandr O. Grygorenko et al.

Summary: Current medicinal chemistry heavily relies on the quality of building blocks, with an emergence of many novel (or well-overlooked) chemotypes for drug discovery. This includes adapting new synthetic methodologies, designing new bioisosteres, and paying attention to underrated structural motifs.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2021)

Add to Collection
Article Chemistry, Medicinal

An Exploration of Chemical Properties Required for Cooperative Stabilization of the 14-3-3 Interaction with NF-κB-Utilizing a Reversible Covalent Tethering Approach

Madita Wolter et al.

Summary: This study describes the systematic bottom-up development of a reversible covalent PPI stabilizer and investigates how its chemical properties affect the structural changes in the ternary 14-3-3/p65/molecular glue complex, ultimately leading to increased stability and high cooperativity.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Medicinal

Development of Covalent, Clickable Probes for Adenosine A1 and A3 Receptors

Phuc N. H. Trinh et al.

Summary: This study presents the development of the first bifunctional ligands for adenosine A(1) receptor and adenosine A(3) receptor, which possess nanomolar affinity and irreversible binding properties. These ligands can aid in target validation and direct visualization of receptors in different native environments. They also exhibit moderate selectivity over A(2A) and A(2B) adenosine receptors.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Nucleus-Independent Chemical Shift (NICS) as a Criterion for the Design of New Antifungal Benzofuranones

Maria de los Angeles Zermeno-Macias et al.

Summary: The study indicates that aromaticity plays an important role in molecular design, and the use of nucleus-independent chemical shifts (NICS) is an effective criterion for evaluating the antifungal activity of indol-4-ones. A linear regression analysis showed a significant relationship between NICS and antifungal activity, with varying effects on different series of compounds. Furthermore, the validity of the equations was confirmed through the synthesis and testing of benzofuran-4-ones, supporting the utility of NICS in the molecular design of compounds with antifungal activity.

MOLECULES (2021)

Add to Collection
Article Chemistry, Organic

SuFExable Isocyanides for Ugi Reaction: Synthesis of Sulfonyl Fluoro Peptides

Shuheng Xu et al.

Summary: The sulfonyl fluoro isocyanides were developed as a new type of SuFExable synthon and utilized as building blocks in the Ugi reaction. This study established the Ugi reaction and explored its substrate scope, allowing for the one-step synthesis of various sulfonyl fluoro alpha-amino amides and peptides. This protocol presents a novel approach for SuFExable building blocks and click chemistry, as well as offering a distinct method for sulfonyl fluoro peptides.

ORGANIC LETTERS (2021)

Add to Collection
Article Chemistry, Organic

Enantioselective Addition of Azlactones to Ethylene Sulfonyl Fluoride via Dual Catalysis

Dong-yu Zhu et al.

Summary: Enantioselective conjugate addition of azlactones to ethylene sulfonyl fluoride has been achieved effectively via cooperative catalysis, providing structurally diverse azlactone sulfonyl fluoride derivatives for drug discovery purposes.

ORGANIC LETTERS (2021)

Add to Collection
Article Chemistry, Organic

Transition metal-free regioselective synthesis of triazolyl aliphatic sulfonyl fluorides

Shadrack Wilson Lucas et al.

Summary: An efficient and metal-free method has been developed for exclusively regioselective construction of aliphatic sulfonyl fluoride moiety at the C4 position of 1,2,3-triazole ring in up to 95 % isolated yield.

TETRAHEDRON (2021)

Add to Collection
Article Biochemistry & Molecular Biology

Structure-activity relationship, in vitro and in vivo evaluation of novel dienyl sulphonyl fluorides as selective BuChE inhibitors for the treatment of Alzheimer's disease

Chengyao Wu et al.

Summary: Compound A10, as a selective BuChE inhibitor, exhibits neuroprotective effects, good safety profile, and can effectively restore Aβ (1-42)-induced cognitive dysfunction.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Radical-mediated vicinal addition of alkoxysulfonyl/fluorosulfonyl and trifluoromethyl groups to aryl alkyl alkynes

Xinrui Dong et al.

Summary: The addition of trifluoromethyl sulfonyl radicals to alkynes is a valuable method for constructing highly functionalized sulfonyl compounds. This process shows broad functional group compatibility and potential in drug discovery and chemical biology.

CHEMICAL SCIENCE (2021)

Add to Collection
Article Chemistry, Organic

A general approach to nitrile- and sulfonyl fluoride-substituted cyclopropanes

Zai-Wei Zhang et al.

Summary: Both cis and trans configurations of functionalized cyano cyclopropane bearing sulfonyl fluoride moiety can be accessed through Corey-Chaykovsky cyclopropanation reactions. This protocol is mild and leads to good yields with excellent functional group compatibility. Further applications of these compounds in SuFEx reactions and cyano reductions have also been successfully achieved in good yields.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Photoredox-catalyzed aminofluorosulfonylation of unactivated olefins

Tao Zhong et al.

Summary: This study successfully reported the first three-component aminofluorosulfonylation of unactivated olefins by merging photoredox-catalyzed proton-coupled electron transfer (PCET) activation with radical relay processes, efficiently affording various aliphatic sulfonyl fluorides featuring a privileged 5-membered heterocyclic core under mild conditions with good functional group tolerance. The synthetic potential of the sulfonyl fluoride products was examined by diverse transformations including SuFEx reactions and transition metal-catalyzed cross-coupling reactions, with mechanistic studies demonstrating the involvement of amidyl radicals, alkyl radicals, and sulfonyl radicals in this difunctionalization transformation.

CHEMICAL SCIENCE (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Photoactive electron donor-acceptor complex platform for Ni-mediated C(sp3)-C(sp2) bond formation

Lisa Marie Kammer et al.

Summary: A dual photochemical/nickel-mediated decarboxylative strategy for the assembly of C(sp(3))-C(sp(2)) linkages has been developed. This platform utilizes commercially available Hantzsch ester as an organic photoreductant to generate catalytically active Ni(0) species under light irradiation, enabling the coupling of diverse C(sp(3))-centered radical architectures with (hetero)aryl bromides. The protocol proceeds under mild reaction conditions and is compatible with sensitive functional groups and pharmaceutically relevant cores.

CHEMICAL SCIENCE (2021)

Add to Collection
Article Chemistry, Organic

Design, synthesis, and evaluation of positron emission tomography/fluorescence dual imaging probes for targeting facilitated glucose transporter 1 (GLUT1)

Richard Yuen et al.

Summary: The study aimed to develop novel glucose-based dual imaging probes for PET and fluorescence imaging. Among the compounds tested, 2-FBDG showed favorable fluorescent properties and similar potency to 2-NBDG in competing for GLUT1 transport in breast cancer cells.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination

Kedong Yuan et al.

Summary: In the arylation reaction of gem-difluoroalkenes using arylsulfonyl chlorides catalyzed by Pd-II/Cu-I, an alternate low-energy route involving beta-H elimination is proposed to avoid beta-F elimination, leading to the synthesis of difluorinated products. This reaction allows exploration of new reactivities of unstable fluorinated alkyl-metal species, and provides new opportunities for transforming readily available fluorinated alkenes into more elaborate substructures.

CHEMICAL SCIENCE (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Molecular design principles of ionic liquids with a sulfonyl fluoride moiety

David J. Siegel et al.

Summary: A new method for developing sulfonyl fluoride-functionalized ionic liquids with structural diversity has been reported. These ionic liquids exhibit properties consistent with their classification as ionic liquids. In-depth understanding of structure-property correlations was gained through a combination of methods including molecular design, synthesis, computational modeling, and X-ray crystallographic studies.

NEW JOURNAL OF CHEMISTRY (2021)

Add to Collection
Article Chemistry, Multidisciplinary

Metal-Free Synthesis of Functional 1-Substituted-1,2,3-Triazoles from Ethenesulfonyl Fluoride and Organic Azides

Marie-Claire Giel et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Ligand Conformational Bias Drives Enantioselective Modification of a Surface-Exposed Lysine on Hsp90

Adolfo Cuesta et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection
Article Chemistry, Organic

Arenesulfonyl Fluoride Synthesis via Copper-Catalyzed Fluorosulfonylation of Arenediazonium Salts

Yongan Liu et al.

ORGANIC LETTERS (2020)

Add to Collection
Article Chemistry, Organic

Arylsulfonyl fluoride boronic acids: Preparation and coupling reactivity

Terry Shing-Bong Lou et al.

TETRAHEDRON (2020)

Add to Collection
Article Chemistry, Medicinal

Discovery of Isoxazole Amides as Potent and Selective SMYD3 Inhibitors

Dai-Shi Su et al.

ACS MEDICINAL CHEMISTRY LETTERS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2-Substituted-Alkynyl-1-Sulfonyl Fluoride (SASF) Hubs

Christopher J. Smedley et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection
Review Chemistry, Organic

Recent Advances of Sulfonylation Reactions in Water

Li Wu et al.

CURRENT ORGANIC SYNTHESIS (2020)

Add to Collection
Article Chemistry, Organic

Synthesis of Functionalized Bridged Bicyclic Sulfonamides with a Bridgehead Nitrogen Atom

Oleksandr P. Blahun et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2020)

Add to Collection
Article Chemistry, Organic

Synthesis of the 1-Bromotricyclo[4.1.0.02,7]heptane Adduct with 2-Bromoethanesulfonyl Bromide and Its Transformations

S. G. Kostryukov et al.

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY (2020)

Add to Collection
Article Chemistry, Organic

A Simple Protocol for the Stereoselective Construction of Enaminyl Sulfonyl Fluorides

Jing Leng et al.

ORGANIC LETTERS (2020)

Add to Collection
Article Chemistry, Organic

SuFEx Activation with Ca(NTf2)2 : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides

Subham Mahapatra et al.

ORGANIC LETTERS (2020)

Add to Collection
Article Chemistry, Applied

An Easy, General and Practical Method for the Construction of Alkyl Sulfonyl Fluorides

Xu Zhang et al.

ADVANCED SYNTHESIS & CATALYSIS (2020)

Add to Collection
Article Chemistry, Organic

Construction of Benzo-1,2,3-thiazaphosphole Heterocycles by Annulations of ortho-Phosphinoarenesulfonyl Fluorides with Trimethylsilyl Azide

Wenjun Luo et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

Add to Collection
Article Chemistry, Organic

Protocol for Stereoselective Construction of Highly Functionalized Dienyl Sulfonyl Fluoride Warheads

Zai-Wei Zhang et al.

JOURNAL OF ORGANIC CHEMISTRY (2020)

Add to Collection
Article Chemistry, Organic

Synthesis of sulfonamide and their synthetic and therapeutic applications: Recent advances

Shovan Mondal et al.

TETRAHEDRON (2020)

Add to Collection
Article Chemistry, Organic

Chemoselective reaction of bifunctional carboxysulfonic acid systems: Preparation of useful intermediates for chemiluminescent, fluorescent and UV absorbing bifunctional linkers

Richard A. Haack et al.

TETRAHEDRON LETTERS (2020)

Add to Collection
Article Chemistry, Organic

Clickable Transformation of Nitriles (RCN) to Oxazolyl Sulfonyl Fluoride Warheads

Wan-Yin Fang et al.

ORGANIC LETTERS (2020)

Add to Collection
Article Biochemistry & Molecular Biology

Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents

Paul J. Koovits et al.

RSC MEDICINAL CHEMISTRY (2020)

Add to Collection
Article Chemistry, Organic

Light-induced [2+2] cycloadditions for the construction of cyclobutane-fused pyridinyl sulfonyl fluorides

Jing Liu et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Iridium-catalyzed C-H amidation of s-tetrazines

Huan Xiong et al.

CHEMICAL COMMUNICATIONS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

But-3-ene-1,3-disulfonyl difluoride (BDF): a highly selective SuFEx clickable hub for the quick assembly of sultam-containing aliphatic sulfonyl fluorides

Chen Li et al.

CHEMICAL COMMUNICATIONS (2020)

Add to Collection
Article Chemistry, Multidisciplinary

Dual ligand-promoted palladium-catalyzed nondirected C-H alkenylation of aryl ethers

Biao Yin et al.

CHEMICAL COMMUNICATIONS (2020)

Add to Collection
Article Chemistry, Organic

Synthesis of unsymmetrical disulfides via PPh3-mediated reductive coupling of thiophenols with sulfonyl chlorides

Dungai Wang et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2020)

Add to Collection
Article Chemistry, Multidisciplinary

A novel sulfonamide derivative as a strong and selective apototic agent against hematological malignancies

Alisson Bigolin et al.

CHEMICAL PAPERS (2020)

Add to Collection
Article Chemistry, Organic

2-Azidoethane-1-sulfonylfluoride (ASF): A Versatile Bis-clickable Reagent for SuFEx and CuAAC Click Reactions

Xu Zhang et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2019)

Add to Collection
Article Chemistry, Medicinal

Development of Covalent Ligands for G Protein-Coupled Receptors: A Case for the Human Adenosine A3 Receptor

Xue Yang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Add to Collection
Article Chemistry, Organic

Synthesis of β-Arylethenesulfonyl Fluoride via Pd-Catalyzed Nondirected C-H Alkenylation

Xiao-Yue Chen et al.

ORGANIC LETTERS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)-Derived Connective Hubs for Bioconjugation to DNA and Proteins

Feng Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Applied

Hydrogenation of nitroaromatics to anilines catalyzed by air-stable arene ruthenium (II)-NNN pincer complexes

Jayaraman Pitchaimani et al.

APPLIED ORGANOMETALLIC CHEMISTRY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Late-Stage Direct o-Alkenylation of Phenols by PdII-Catalyzed C-H Functionalization

Yandong Dou et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Add to Collection
Article Chemistry, Medicinal

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

George A. Naclerio et al.

CHEMMEDCHEM (2019)

Add to Collection
Article Chemistry, Organic

Directed ortho -Metalation of Arenesulfonyl Fluorides and Aryl Fluorosulfates

Alicja Talko et al.

SYNTHESIS-STUTTGART (2019)

Add to Collection
Article Chemistry, Organic

Optimised synthesis of a nitroCBI hypoxia-activated prodrug with substantial anticancer activity

Ho H. Lee et al.

TETRAHEDRON (2019)

Add to Collection
Article Chemistry, Applied

Stereoselective Construction of Nitrile-Substituted Cyclopropanes from 2-Substituted Ethenesulfonyl Fluorides via Carbon-Sulfur Bond Cleavage

Hao Liu et al.

ADVANCED SYNTHESIS & CATALYSIS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Utilizing Carbonyl Coordination of Native Amides for Palladium-Catalyzed C(sp3)-H Olefination

Hojoon Park et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Organic

Converting (E)-(Hetero)arylethanesulfonyl Fluorides to (Z)-(Hetero)arylethanesulfonyl Fluorides Under Light Irradiation

Yu-Mei Huang et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2019)

Add to Collection
Article Chemistry, Medicinal

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A

David J. Leaver et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Add to Collection
Review Chemistry, Organic

Synthesis of Thioethers from Sulfonyl Chlorides, Sodium Sulfinates, and Sulfonyl Hydrazides

Ronghai Wu et al.

SYNTHESIS-STUTTGART (2019)

Add to Collection
Article Chemistry, Physical

Synthetic and Mechanistic Studies of a Versatile Heteroaryl Thioether Directing Group for Pd(II) Catalysis

Andrew M. Romine et al.

ACS CATALYSIS (2019)

Add to Collection
Article Chemistry, Medicinal

1,3,4-Oxadiazol-2-ylbenzenesulfonamides as privileged structures for the inhibition of monoamine oxidase B

Anton Shetnev et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Preparation of (Pentafluorosulfanyl)benzenes by Direct Fluorination of Diaryldisulfides: Synthetic Approach and Mechanistic Aspects

Javier Ajenjo et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Add to Collection
Article Chemistry, Organic

Construction of α-(Hetero)aryl Ethenesulfonyl Fluorides for SuFEx Click Chemistry

Jing Leng et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Cyclic Alkenylsulfonyl Fluorides: Palladium-Catalyzed Synthesis and Functionalization of Compact Multifunctional Reagents

Terry Shing-Bong Lou et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4

Alejandro Gomez-Palomino et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Blue Phosphorescence with High Quantum Efficiency Engaging the Trifluoromethylsulfonyl Group to Iridium Phenylpyridine Complexes

Jin-Hyoung Kim et al.

INORGANIC CHEMISTRY (2019)

Add to Collection
Article Chemistry, Medicinal

Structure-Activity Relationship Studies To Identify Affinity Probes in Bis-aryl Sulfonamides That Prolong Immune Stimuli

Michael Chan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Add to Collection
Article Chemistry, Organic

Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams

Jie Chen et al.

ORGANIC LETTERS (2019)

Add to Collection
Article Chemistry, Physical

Rh(I)-Diene-Catalyzed Addition of (Hetero)aryl Functionality to 1,3-Dienylsulfonyl Fluorides Achieving Exclusive Regioselectivity and High Enantioselectivity: Generality and Mechanism

Balakrishna Moku et al.

ACS CATALYSIS (2019)

Add to Collection
Article Biochemistry & Molecular Biology

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I

Dongwei Kang et al.

CHEMICAL BIOLOGY & DRUG DESIGN (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Direct Oxidation of Csp3-H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow

Mathieu Lesieur et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Zinc-Mediated Intermolecular Reductive Radical Fluoroalkylsulfination of Unsaturated Carbon-Carbon Bonds with Fluoroalkyl Bromides and Sulfur Dioxide

Yongan Liu et al.

CHEMISTRY-A EUROPEAN JOURNAL (2019)

Add to Collection
Article Chemistry, Medicinal

Discovery of novel arylethenesulfonyl fluorides as potential candidates against methicillin-resistant of Staphylococcus aureus (MRSA) for overcoming multidrug resistance of bacterial infections

Gao-Feng Zha et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Add to Collection
Article Chemistry, Medicinal

Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72

Jonathan Pettinger et al.

JOURNAL OF MEDICINAL CHEMISTRY (2019)

Add to Collection
Article Chemistry, Multidisciplinary

An in situ combinatorial methodology to synthesize and screen chemical probes

Antonie J. van der Zouwen et al.

CHEMICAL COMMUNICATIONS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

Copper-catalyzed radical approach to allenyl iodides

Yulong Song et al.

CHEMICAL COMMUNICATIONS (2019)

Add to Collection
Article Chemistry, Multidisciplinary

A rapid one-step surface functionalization of polyvinyl chloride by combining click sulfur(vi)-fluoride exchange with benzophenone photochemistry

Wenying Liu et al.

CHEMICAL COMMUNICATIONS (2019)

Add to Collection
Review Chemistry, Multidisciplinary

The growing applications of SuFEx click chemistry

A. S. Barrow et al.

CHEMICAL SOCIETY REVIEWS (2019)

Add to Collection
Article Chemistry, Organic

Chemoselective cyclization of N-sulfonyl ketimines with ethenesulfonyl fluorides: access to trans-cyclopropanes and fused-dihydropyrroles

Sanjeeva Kumar Arupula et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

Add to Collection
Article Chemistry, Medicinal

Small molecule inhibitors of anthrax edema factor

Guan-Sheng Jiao et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

1-Bromoethene-1-sulfonyl fluoride (BESF) is another good connective hub for SuFEx click chemistry

Christopher J. Smedley et al.

CHEMICAL COMMUNICATIONS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

1-Bromoethene-1-sulfonyl fluoride (1-Br-ESF), a new SuFEx clickable reagent, and its application for regioselective construction of 5-sulfonylfluoro isoxazoles

Jing Leng et al.

CHEMICAL COMMUNICATIONS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting-Group-Free Synthesis of Sulfonamides

Sergey A. Zhersh et al.

CHEMISTRY-A EUROPEAN JOURNAL (2018)

Add to Collection
Article Chemistry, Medicinal

Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors

Frank Lovering et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Add to Collection
Article Chemistry, Organic

Rh-Catalyzed Carboxylates Directed C-H Activation for the Synthesis of ortho-Carboxylic 2-Arylethenesulfonyl Fluorides: Access to Unique Electrophiles for SuFEx Click Chemistry

Shi-Meng Wang et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Add to Collection
Article Chemistry, Organic

[3+2] Cycloaddition of an Azomethyne Ylide and Vinyl Sulfonyl Fluorides ? an Approach to Pyrrolidine-3-sulfonyl Fluorides

Volodymyr L. Mykhalchuk et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Add to Collection
Review Chemistry, Organic

Sulfonyl Fluorides (SFs): More Than Click Reagents?

Praveen K. Chinthakindi et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Add to Collection
Article Biochemical Research Methods

Synthesis, bioconjugation and stability studies of [F-18]ethenesulfonyl fluoride

Bo Zhang et al.

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS (2018)

Add to Collection
Article Chemistry, Medicinal

Potent and Highly Selective Inhibitors of the Proteasome Trypsin-like Site by Incorporation of Basic Side Chain Containing Amino Acid Derived Sulfonyl Fluorides

Raik Artschwager et al.

JOURNAL OF MEDICINAL CHEMISTRY (2018)

Add to Collection
Article Chemistry, Organic

[2+2]-Photocycloaddition of N-Benzylmaleimide to Alkenes As an Approach to Functional 3-Azabicyclo[3.2.0]heptanes

Yevhen A. Skalenko et al.

JOURNAL OF ORGANIC CHEMISTRY (2018)

Add to Collection
Article Chemistry, Multidisciplinary

C(alkenyl)-H Activation via Six-Membered Palladacycles: Catalytic 1,3-Diene Synthesis

Mingyu Liu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection
Article Chemistry, Organic

Temperature Controlled Selective C-S or C-C Bond Formation: Photocatalytic Sulfonylation versus Arylation of Unactivated Heterocycles Utilizing Aryl Sulfonyl Chlorides

Santosh K. Pagire et al.

ORGANIC LETTERS (2018)

Add to Collection
Article Chemistry, Organic

Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride

Joice Thomas et al.

ORGANIC LETTERS (2018)

Add to Collection
Article Chemistry, Organic

Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides

Paramita Mukherjee et al.

ORGANIC LETTERS (2018)

Add to Collection
Article Chemistry, Organic

Copper-Catalyzed Difunctionalization of Allenes with Sulfonyl Iodides Leading to (E)-alpha-lodomethyl Vinylsulfones

Ning Lu et al.

ORGANIC LETTERS (2018)

Add to Collection
Article Chemistry, Organic

Efficient synthesis of chalcone-4 '-sulfonyl chlorides and fluorides

Dmitrii Semenok et al.

TETRAHEDRON LETTERS (2018)

Add to Collection
Article Chemistry, Organic

A convenient synthesis of (E)-conjugated polyene sulfonyl derivatives with excellent stereospecificity

Chunyan Yu et al.

TETRAHEDRON LETTERS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis of a Series of 2-Aminodiarylsulfones by BrOnsted Acid Mediated Regioselective Fries Type Rearrangement of N-Alkyl-N -arylbenzenesulfonamides

Sudarshan Debnath et al.

CHEMISTRYSELECT (2018)

Add to Collection
Article Chemistry, Organic

Hetaryl Bromides Bearing the SO2F Group - Versatile Substrates for Palladium-Catalyzed C-C Coupling Reactions

Artem Yu. Cherepakha et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2018)

Add to Collection
Article Chemistry, Organic

Synthesis and biological activity of a CXCR4-targeting bis(cyclam) lipid

Anna D. Peters et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2018)

Add to Collection
Article Chemistry, Organic

2-Azaadamantane N-oxyl (AZADO)/Cu Catalysis Enables Chemoselective Aerobic Oxidation of Alcohols Containing Electron-Rich Divalent Sulfur Functionalities

Yusuke Sasano et al.

ORGANIC LETTERS (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Nucleophilicity and Electrophilicity Parameters for Predicting Absolute Rate Constants of Highly Asynchronous 1,3-Dipolar Cycloadditions of Aryldiazomethanes

Harish Jangra et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection
Article Chemistry, Applied

(Chlorosulfonyl)benzenesulfonyl Fluorides-Versatile Building Blocks for Combinatorial Chemistry: Design, Synthesis and Evaluation of a Covalent Inhibitor Library

Kateryna A. Tolmachova et al.

ACS COMBINATORIAL SCIENCE (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction

Mzilikazi F. Khumalo et al.

RSC ADVANCES (2018)

Add to Collection
Article Chemistry, Multidisciplinary

A Vinyl Sulfone-Based Fluorogenic Probe Capable of Selective Labeling of PHGDH in Live Mammalian Cells

Sijun Pan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection
Article Biochemistry & Molecular Biology

Targeted Covalent Inhibition of Prolyl Oligopeptidase (POP): Discovery of Sulfonylfluoride Peptidomimetics

Salvador Guardiola et al.

CELL CHEMICAL BIOLOGY (2018)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis of the Right-Side Structure of Type B Physalins

Masaki Morita et al.

ISRAEL JOURNAL OF CHEMISTRY (2017)

Add to Collection
Article Chemistry, Organic

Pd-Catalyzed Conversion of Aryl Iodides to Sulfonyl Fluorides Using SO2 Surrogate DABSO and Selectfluor

Ariana L. Tribby et al.

JOURNAL OF ORGANIC CHEMISTRY (2017)

Add to Collection
Article Chemistry, Organic

New methods for the synthesis of 4H-dithieno[3,2-b: 2', 3'-d] pyrrole

Sebastian Foertsch et al.

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Molecular Engineering of Robustness and Resilience in Enzymatic Reaction Networks

Albert S. Y. Wong et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Enabling the Cross-Coupling of Tertiary Organoboron Nucleophiles through Radical-Mediated Alkyl Transfer

David N. Primer et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)

Add to Collection
Article Biochemistry & Molecular Biology

Synthesis and Antibacterial Activity of Benzo[4,5]isothiazolo[2,3-a]pyrazine-6,6-dioxide Derivatives

Jatinder P. Bassin et al.

MOLECULES (2017)

Add to Collection
Article Chemistry, Organic

Metal- and base-free reductive coupling reaction of P(O)-H with aryl/alkyl sulfonyl chlorides: a novel protocol for the construction of P-S-C bonds

Dungai Wang et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2017)

Add to Collection
Article Chemistry, Organic

A study of the reactivity of S(VI)-F containing warheads with nucleophilic amino-acid side chains under physiological conditions

H. Mukherjee et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2017)

Add to Collection
Article Chemistry, Organic

A Synthesis of Dual Warhead β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams

Praveen K. Chinthakindi et al.

ORGANIC LETTERS (2017)

Add to Collection
Review Chemistry, Multidisciplinary

Visible Light Photoredox Activation of Sulfonyl Chlorides: Applications in Organic Synthesis

Renu Chaudhary et al.

CHEMISTRYSELECT (2017)

Add to Collection
Article Chemistry, Applied

Gram-Scale Synthesis of β-(Hetero)arylethenesulfonyl Fluorides via a Pd(OAc)2 Catalyzed Oxidative Heck Process with DDQ or AgNO3 as an Oxidant

Gao-Feng Zha et al.

ADVANCED SYNTHESIS & CATALYSIS (2017)

Add to Collection
Article Chemistry, Applied

Synthesis and spectral properties of near-IR polymethine dyes derived from tris(2,2,3,3,4,4,5,5-octafluoropenty1)-9H-fluorene-2,4,7-trisulfonate

Irina V. Kurdyukova et al.

DYES AND PIGMENTS (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides

Gao-Feng Zha et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection
Article Chemistry, Organic

A chemoselective and continuous synthesis of m-sulfamoylbenzamide analogues

Arno Verlee et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub

Suhua Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Add to Collection
Article Chemistry, Multidisciplinary

Ethenesulfonyl Fluoride: The Most Perfect Michael Acceptor Ever Found?

Quan Chen et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT

Chao Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

Add to Collection
Article Chemistry, Applied

Desulfonative pd-catalyzed coupling of aryl trifluoroborates with arylsulfonyl chlorides

Zhen Wei et al.

APPLIED ORGANOMETALLIC CHEMISTRY (2016)

Add to Collection
Article Chemistry, Medicinal

Identification of nonabsorbable inhibitors of the scavenger receptor-BI (SR-BI) for tissue-specific administration

Steven M. Sparks et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Add to Collection
Article Chemistry, Medicinal

Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators

Iain R. Greig et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis

Olugbeminiyi Fadeyi et al.

CHEMBIOCHEM (2016)

Add to Collection
Review Chemistry, Organic

Progress on the Sulfonylation and Desulfonylative Reactions of Sulfonyl Chlorides

Ying Fu et al.

CHINESE JOURNAL OF ORGANIC CHEMISTRY (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Janus head type lone pair-π-lone pair and S•••F•••S interactions in retaining hexafluorobenzene

Sonam Mehrotra et al.

CRYSTENGCOMM (2016)

Add to Collection
Article Chemistry, Organic

Oxidative reaction of 2-aminopyridine-3-sulfonyl chlorides with tertiary amines

Huiping Wei et al.

HETEROCYCLIC COMMUNICATIONS (2016)

Add to Collection
Article Chemistry, Medicinal

Unexpected Discovery of Dichloroacetate Derived Adenosine Triphosphate Competitors Targeting Pyruvate Dehydrogenase Kinase To Inhibit Cancer Proliferation

Shao-Lin Zhang et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Add to Collection
Article Chemistry, Medicinal

Potent Suppressive Effects of 1-Piperidinylimidazole Based Novel P2X7 Receptor Antagonists on Cancer Cell Migration and Invasion

Jin-Hee Park et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Discovery of a potential lead compound for treating leprosy with dapsone resistance mutation in M. leprae folP1

J. Nisha et al.

MOLECULAR BIOSYSTEMS (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives

Chandani Patel et al.

MOLECULES (2016)

Add to Collection
Article Chemistry, Organic

Horner-Wadsworth-Emmons approach to piperlongumine analogues with potent anti-cancer activity

Li-Chen Han et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2016)

Add to Collection
Article Chemistry, Organic

Visible-light photocatalyzed synthesis of 2-aryl N-methylpyrroles, furans and thiophenes utilizing arylsulfonyl chlorides as a coupling partner

Palani Natarajan et al.

TETRAHEDRON (2016)

Add to Collection
Article Chemistry, Organic

Direct synthesis of thiophosphates by reaction of diphenylphosphine oxide with sulfonyl chlorides

Wei He et al.

TETRAHEDRON (2016)

Add to Collection
Article Chemistry, Organic

Design, synthesis, and evaluation of cell permeable probes for protein kinases

Yu-Ling Hsu et al.

TETRAHEDRON (2016)

Add to Collection
Article Chemistry, Multidisciplinary

Advanced generation of paeonol-phenylsufonyl derivatives as potential anti-HBV agents

Y. P. Huang et al.

RSC ADVANCES (2016)

Add to Collection
Article Biochemistry & Molecular Biology

Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes

Erik C. Hett et al.

ACS CHEMICAL BIOLOGY (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Direct Photoredox-Catalyzed Reductive Difluoromethylation of Electron-Deficient Alkenes

Xiao-Jun Tang et al.

CHEMISTRY-A EUROPEAN JOURNAL (2015)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Synthesis and X-ray structure analysis of cytotoxic heptacoordinate sulfonamide salan titanium(IV)-bis-chelates

Tiankun Zhao et al.

DALTON TRANSACTIONS (2015)

Add to Collection
Article Chemistry, Medicinal

5′-(N-aminoacyl)-sulfonamido-5′-deoxyadenosine: Attempts for a stable alternative for aminoacyl-sulfamoyl adenosines as aaRS inhibitors

Bharat Gadakh et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Carbomethoxydifluoromethylation of enol acetates with methyl (chlorosulfonyl)difluoroacetate using visible-light photoredox catalysis. Synthesis of 2,2-difluoro-γ-ketoesters

Charles S. Thomoson et al.

JOURNAL OF FLUORINE CHEMISTRY (2015)

Add to Collection
Article Chemistry, Medicinal

Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639

Qingwei Zhang et al.

ACS MEDICINAL CHEMISTRY LETTERS (2015)

Add to Collection
Article Chemistry, Organic

Synthesis of 10,10-Dioxo-10λ6-Phenoxathiin Derivatives by Reaction of 4,4′-Oxydibenzoic Acid with Sulfur-Containing Electrophiles

V. S. Yashchenko et al.

CHEMISTRY OF HETEROCYCLIC COMPOUNDS (2015)

Add to Collection
Article Chemistry, Organic

Chloro, Difluoromethylation and Chloro, Carbomethoxydifluoromethylation: Reaction of Radicals Derived from RfSO2Cl with Unactivated Alkenes under Metal-Free Conditions

Charles S. Thomoson et al.

JOURNAL OF ORGANIC CHEMISTRY (2015)

Add to Collection
Article Multidisciplinary Sciences

2-Benzazolyl-4-Piperazin-1-Ylsulfonylbenzenecarbohydroxamic Acids as Novel Selective Histone Deacetylase-6 Inhibitors with Antiproliferative Activity

Lei Wang et al.

PLOS ONE (2015)

Add to Collection
Article Chemistry, Medicinal

Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation

Nicole C. Goodwin et al.

ACS MEDICINAL CHEMISTRY LETTERS (2015)

Add to Collection
Article Chemistry, Multidisciplinary

Metal- and base-free syntheses of aryl/alkylthioindoles by the iodine-induced reductive coupling of aryl/alkyl sulfonyl chlorides with indoles

Gullapalli Kumaraswamy et al.

RSC ADVANCES (2015)

Add to Collection
Review Chemistry, Multidisciplinary

Sulfur(VI) Fluoride Exchange (SuFEx): Another Good Reaction for Click Chemistry

Jiajia Dong et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2014)

Add to Collection
Article Chemistry, Medicinal

1,2,4-Benzothiadiazine-1,1-dioxide Derivatives as Ionotropic Glutamate Receptor Ligands: Synthesis and Structure-Activity Relationships

Flavia Varano et al.

ARCHIV DER PHARMAZIE (2014)

Add to Collection
Article Chemistry, Multidisciplinary

Generation of C2F5CHN2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes

Pavel K. Mykhailiuk

CHEMISTRY-A EUROPEAN JOURNAL (2014)

Add to Collection
Article Chemistry, Organic

One-Pot Synthesis of CF3-Substituted Pyrazolines/Pyrazoles from Electron-Deficient Alkenes/Alkynes and CF3CHN2 Generated in situ: Optimized Synthesis of Tris(trifluoromethyl) pyrazole

Evgeniy Y. Slobodyanyuk et al.

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2014)

Add to Collection
Article Chemistry, Medicinal

Fluorescent Non-peptidic RGD Mimetics with High Selectivity for αVβ3 vs αIIbβ3 Integrin Receptor: Novel Probes for in Vivo Optical Imaging

Wael Alsibai et al.

JOURNAL OF MEDICINAL CHEMISTRY (2014)

Add to Collection
Article Chemistry, Organic

Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors

Inderpreet Arora et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2014)

Add to Collection
Article Chemistry, Organic

Synthesis of 5-(ethylsulfonyl)-2-methoxyaniline: An important pharmacological fragment of VEGFR2 and other inhibitors

Miroslav Murar et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2013)

Add to Collection
Article Chemistry, Medicinal

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties

Janet Gunzner-Toste et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Add to Collection
Article Chemistry, Medicinal

Design, synthesis and biological activities of some 7-aminocephalosporanic acid derivatives

Serap Basoglu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Add to Collection
Article Chemistry, Medicinal

Design, Synthesis, and Biological Evaluation of (E)-N-Aryl-2-arylethenesulfonamide Analogues as Potent and Orally Bioavailable Microtubule-Targeted Anticancer Agents

M. V. Ramana Reddy et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Add to Collection
Article Chemistry, Organic

Cu-Catalyzed Selective Mono-N-pyridylation: Direct Access to 2-AminoDMAP/Sulfonamides as Bifunctional Organocatalysts

Murat Isik et al.

JOURNAL OF ORGANIC CHEMISTRY (2013)

Add to Collection
Article Chemistry, Physical

ESIPT and Photodissociation of 3-Hydroxychromone in Solution: Photoinduced Processes Studied by Static and Time-Resolved UV/Vis, Fluorescence, and IR Spectroscopy

Katharina Chevalier et al.

JOURNAL OF PHYSICAL CHEMISTRY A (2013)

Add to Collection
Article Chemistry, Multidisciplinary

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

Neil P. Grimster et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis and Evaluation of Activity-Based Probes Carrying a 5′-Fluorosulfonylbenzoyl Adenosine Moiety for Protein Kinases

Yu-Ling Hsu et al.

JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2013)

Add to Collection
Review Chemistry, Organic

Synthetic Routes of Sulfonamide Derivatives: A Brief Review

Muhammad Ashfaq et al.

MINI-REVIEWS IN ORGANIC CHEMISTRY (2013)

Add to Collection
Article Chemistry, Medicinal

Glyoxalase 1 and 2 Enzyme Inhibitory Activity of 6-Sulfamoylsaccharin and Sulfocoumarin Derivates

Marina Makrecka et al.

LETTERS IN DRUG DESIGN & DISCOVERY (2013)

Add to Collection
Article Chemistry, Organic

SYNTHESIS OF NEW FUNCTIONALIZED CHIRAL IONIC LIQUID AND ITS ORGANOCATALYTIC ASYMMETRIC MICHAEL ADDITION

Jian Li et al.

SYNTHETIC COMMUNICATIONS (2013)

Add to Collection
Article Chemistry, Organic

Chemoselective synthesis of aryl carboxamido sulfonic acid derivatives

Yung-Lin Yang et al.

TETRAHEDRON (2013)

Add to Collection
Article Chemistry, Medicinal

Sulphonamide and sulphonyl-hydrazone cyclic imide derivatives: Antinociceptive activity, molecular modeling and In Silico ADMET screening

Kely N. de Oliveira et al.

ARCHIVES OF PHARMACAL RESEARCH (2012)

Add to Collection
Article Chemistry, Organic

Synthesis and photooxidation of styrene copolymer bearing camphorquinone pendant groups

Branislav Husar et al.

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2012)

Add to Collection
Article Chemistry, Medicinal

Design, synthesis and biological evaluation of β-carboline derivatives as novel inhibitors targeting B-Raf kinase

Botao Xin et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Add to Collection
Article Chemistry, Medicinal

Design and synthesis of procollagen C-proteinase inhibitors

Eric Turtle et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Add to Collection
Article Chemistry, Multidisciplinary

The palladium-catalyzed desulfitative cyanation of arenesulfonyl chlorides and sodium sulfinates

Jianbin Chen et al.

CHEMICAL COMMUNICATIONS (2012)

Add to Collection
Article Chemistry, Multidisciplinary

Sulfonyl Fluoride-Based Prosthetic Compounds as Potential 18F Labelling Agents

James A. H. Inkster et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

Add to Collection
Article Chemistry, Applied

Synthesis and properties of some novel pyrazolone-based heterocyclic azo disperse dyes containing a fluorosulfonyl group

Ajay Singh et al.

DYES AND PIGMENTS (2012)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Interaction of 2,4,6-tris(fluorosulfonyl)chlorobenzene with O-, N-, S-, C-nucleophiles and F-anion

Andrey A. Filatov et al.

JOURNAL OF FLUORINE CHEMISTRY (2012)

Add to Collection
Article Chemistry, Medicinal

Discovery and Structure-Activity Relationship of Potent and Selective Covalent Inhibitors of Transglutaminase 2 for Huntington's Disease

Michael E. Prime et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Add to Collection
Article Chemistry, Medicinal

3-(3,4-Dihydroisoquinolin-2(1H)-ylsulfonyl)benzoic Acids: Highly Potent and Selective Inhibitors of the Type 5 17-β-Hydroxysteroid Dehydrogenase AKR1C3

Stephen M. F. Jamieson et al.

JOURNAL OF MEDICINAL CHEMISTRY (2012)

Add to Collection
Article Chemistry, Applied

Original route to polylactide-polystyrene diblock copolymers containing a sulfonyl group at the junction between both blocks as precursors to functional nanoporous materials

Rim Majdoub et al.

REACTIVE & FUNCTIONAL POLYMERS (2012)

Add to Collection
Article Chemistry, Organic

SYNTHESIS OF A NOVEL SERIES OF 1,6-DISUBSTITUTED-3-(CYCLOHEXYLMETHOXY)-β-CARBOLINE DERIVATIVES VIA MINISCI REACTION

Guowu Lin et al.

SYNTHETIC COMMUNICATIONS (2012)

Add to Collection
Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of novel irreversible serine protease inhibitors using amino acid based sulfonyl fluorides as an electrophilic trap

Arwin J. Brouwer et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Add to Collection
Article Chemistry, Medicinal

Synthesis and biochemical evaluation of triazole/tetrazole-containing sulfonamides against thrombin and related serine proteases

Rogelio Siles et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Add to Collection
Article Chemistry, Multidisciplinary

Palladium-catalyzed desulfitative C-arylation of a benzo[d]oxazole C-H bond with arene sulfonyl chlorides

Manli Zhang et al.

CHEMICAL COMMUNICATIONS (2011)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Copper(II) complexes of hybrid hydroxyquinoline-thiosemicarbazone ligands: GSK3 beta inhibition due to intracellular delivery of copper

James L. Hickey et al.

DALTON TRANSACTIONS (2011)

Add to Collection
Article Chemistry, Medicinal

Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold

Xin Chen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)

Add to Collection
Article Biochemistry & Molecular Biology

Activation of sulfonate ester based matrix metalloproteinase proinhibitors by hydrogen peroxide

Kevin B. Daniel et al.

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY (2011)

Add to Collection
Article Chemistry, Inorganic & Nuclear

A convenient synthetic route to 2,4,6-tris(chlorosulfonyl)- and 2,4,6-tris(fluorosulfonyl)phenol, aniline and chlorobenzene

Vladimir N. Boiko et al.

JOURNAL OF FLUORINE CHEMISTRY (2011)

Add to Collection
Article Chemistry, Organic

Syntheses of a Perfluoroethanesulfonyl Fluoride Vinyl Ether

Changqing Lu et al.

JOURNAL OF ORGANIC CHEMISTRY (2011)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Regioselective C-H Activation of Cyclometalated Bis-Tridentate Ruthenium Complexes

Stacy S. R. Muise et al.

ORGANOMETALLICS (2011)

Add to Collection
Article Chemistry, Multidisciplinary

Free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides

Zhu JieMing et al.

SCIENCE CHINA-CHEMISTRY (2011)

Add to Collection
Article Chemistry, Medicinal

A novel small-molecule inhibitor of IL-6 signalling

Giovanna Zinzalla et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)

Add to Collection
Article Chemistry, Multidisciplinary

A photoreactive crystalline quasiracemate

Rebecca C. Grove et al.

CHEMICAL COMMUNICATIONS (2010)

Add to Collection
Article Chemistry, Medicinal

Synthesis and antimicrobial studies on novel sulfonamides containing 4-azidomethyl coumarin

Mahantesha Basanagouda et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2010)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Reactions of imines with 2,2-difluoro-2-fluorosulfonylacetyl fluoride

Katja Vlasov et al.

JOURNAL OF FLUORINE CHEMISTRY (2010)

Add to Collection
Article Chemistry, Multidisciplinary

Discovery of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation with High Stereoselectivity

Teruo Umemoto et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)

Add to Collection
Article Polymer Science

Phthalate Plasticizers Covalently Bound to PVC: Plasticization with Suppressed Migration

Rodrigo Navarro et al.

MACROMOLECULES (2010)

Add to Collection
Article Chemistry, Organic

Metal-Free Intramolecular Aziridination of Alkenes Using Hypervalent Iodine Based Sulfonyliminoiodanes

Robert M. Moriarty et al.

ORGANIC LETTERS (2010)

Add to Collection
Article Chemistry, Organic

The Electrical Properties of Biphenylenes

Severin Schneebeli et al.

ORGANIC LETTERS (2010)

Add to Collection
Article Chemistry, Organic

Synthesis of isomeric fluoronitrobenzene-sulfonyl chlorides

Sergey Zhersh et al.

TETRAHEDRON (2010)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis and Single Chain Fluorescence of a Sulfonated Conjugated Polymer

Daniel E. Gomez et al.

AUSTRALIAN JOURNAL OF CHEMISTRY (2009)

Add to Collection
Article Chemistry, Medicinal

A Selective Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Chronic Obstructive Pulmonary Disease (COPD): Discovery of (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408)

Wei Li et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Add to Collection
Article Chemistry, Multidisciplinary

Synthesis and Application of Some Alkali-clearable Azo Disperse Dyes Based on Naphthalimide Derivatives

P. Parvizi et al.

JOURNAL OF THE CHINESE CHEMICAL SOCIETY (2009)

Add to Collection
Article Biochemistry & Molecular Biology

1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

Jai Moo Shin et al.

MOLECULES (2009)

Add to Collection
Article Chemistry, Organic

Direct reductive aminations with catalytic molybdenum dioxide dichloride and phenylsilane

Clive A. Smith et al.

TETRAHEDRON LETTERS (2009)

Add to Collection
Article Chemistry, Medicinal

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Sun Hee Kim et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)

Add to Collection
Article Chemistry, Medicinal

Synthesis and antiproliferative activities of isoindigo and azaisoindigo derivatives

Fadoua Bouchikhi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)

Add to Collection
Article Biochemistry & Molecular Biology

Synthesis and biological evaluation of inhibitors of thymidine monophosphate kinase from Bacillus anthracis

Youngjoo Byun et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2008)

Add to Collection
Article Chemistry, Medicinal

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials

Pravin Bendale et al.

JOURNAL OF MEDICINAL CHEMISTRY (2007)

Add to Collection
Article Chemistry, Medicinal

C-8 Modifications of 3-alkyl-1,8-dibenzylxanthines as inhibitors of human cytosolic phosphoenolpyruvate carboxykinase

Sherrie L. Petranico et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Add to Collection
Article Chemistry, Medicinal

From selective substrate analogue factor Xa inhibitors to dual inhibitors of thrombin and factor Xa.: Part 3

Daniel Doennecke et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Add to Collection
Article Chemistry, Medicinal

Azithromycin-sulfonamide conjugates as inhibitors of resistant Streptococcus pyogenes strains

Mirjana Bukvic Krajacic et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2007)

Add to Collection
Article Chemistry, Organic

Introducing difluoromethylene sulfonamide group via nucleophilic addition of difluoromethylene anion with aromatic aldehydes

Jun-Li Li et al.

TETRAHEDRON (2007)

Add to Collection
Article Chemistry, Medicinal

Discovery and optimization of a novel series of liver X receptor-α agonists

LP Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

Add to Collection
Article Chemistry, Organic

A novel synthesis of 2-chloro-4-fluoro-5-nitrobenzenesulfonyl chloride

XH Du et al.

ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL (2005)

Add to Collection
Article Chemistry, Medicinal

Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists

DC Cole et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)

Add to Collection
Article Chemistry, Organic

Arylsulfonate-based nucleophile assisting leaving groups

SD Lepore et al.

JOURNAL OF ORGANIC CHEMISTRY (2005)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Synthesis and antimicrobial activity of some 2(1H)-quinoxalinone-6-sulfonyl derivatives

CA Obafemi et al.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2005)

Add to Collection
Article Chemistry, Medicinal

3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers:: Effect of 6,7-disubstitution on potency and tissue selectivity

P de Tullio et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Add to Collection
Article Chemistry, Medicinal

Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors

PA Harris et al.

JOURNAL OF MEDICINAL CHEMISTRY (2005)

Add to Collection
Article Chemistry, Multidisciplinary

Novel sulfonamide derivatives as inhibitors of histone deacetylase

PW Finn et al.

HELVETICA CHIMICA ACTA (2005)

Add to Collection
Article Chemistry, Physical

Molecular aggregations and supramolecular architectures of amphiphilic PEO17W-OPV3 and its hybrid with silica

CC Hsieh et al.

JOURNAL OF MATERIALS CHEMISTRY (2005)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Trimethylsilyl fluorosulfonyldifluoroacetate (TFDA): a new, highly efficient difluorocarbene reagent

WR Dolbier et al.

JOURNAL OF FLUORINE CHEMISTRY (2004)

Add to Collection
Article Chemistry, Inorganic & Nuclear

Perfluoroalkanesulfonylimides and their lithium salts: synthesis and characterisation of intermediates and target compounds

L Conte et al.

JOURNAL OF FLUORINE CHEMISTRY (2004)

Add to Collection
Article Chemistry, Organic

Palladium-catalyzed Suzuki-Miyaura cross-couplings of sulfonyl chlorides and boronic acids

SR Dubbaka et al.

ORGANIC LETTERS (2004)

Add to Collection
Article Chemistry, Medicinal

Structure-activity relationships of novel potent MurF inhibitors

YG Gu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Add to Collection
Article Chemistry, Organic

Sulfur dioxide mediated one-pot, three- and four-component syntheses of polyfunctional sulfonamides and sulfonic esters: Study of the stereoselectivity of the ene reaction of sulfur dioxide

LC Bouchez et al.

JOURNAL OF ORGANIC CHEMISTRY (2004)

Add to Collection
Article Chemistry, Medicinal

Synthesis and biological evaluation of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one inhibitors of cyclin-dependent kinases

JA Markwalder et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Add to Collection
Article Chemistry, Medicinal

Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists.: 1.: Bicyclo[2.2.1]heptane derivatives

S Mitsumori et al.

JOURNAL OF MEDICINAL CHEMISTRY (2003)

Add to Collection
Article Biochemistry & Molecular Biology

5 '-O-fluorosulfonylbenzoyl esters of purine nucleosides as potential inhibitors of NTPase/helicase and polymerase of Flaviviridae viruses

M Bretner et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2003)

Add to Collection
Article Chemistry, Organic

Cannabinoid CB1 receptor chemical affinity probes: Methods suitable for preparation of isopropyl [11,12-H-3]dodecylfluorophosphonate and [11,12-H-3]dodecanesulfonyl fluoride

Y Segall et al.

SYNTHETIC COMMUNICATIONS (2003)

Add to Collection
Article Chemistry, Medicinal

A three-dimensional quantitative structure-activity relationship study of heparin-binding epidermal growth factor shedding inhibitors using comparative molecular field analysis

R Bursi et al.

JOURNAL OF MEDICINAL CHEMISTRY (2002)

Add to Collection
Article Chemistry, Multidisciplinary

Zn(ODf)(2): preparation and application in asymmetric alkynylation of aldehydes

ZL Chen et al.

CHEMICAL COMMUNICATIONS (2002)

Add to Collection
Article Chemistry, Multidisciplinary

1H and 13C NMR assignments of 2-oxo-2H-1-benzopyran-3-acyl and-3-amide derivatives

FJ Martinez-Martínez et al.

MAGNETIC RESONANCE IN CHEMISTRY (2001)

Add to Collection
Article Chemistry, Organic

A traceless perfluoroalkylsulfonyl (PFS) linker for the deoxygenation of phenols

YJ Pan et al.

ORGANIC LETTERS (2001)

Add to Collection
Article Chemistry, Organic

Concise formation of 4-benzyl piperidines and related derivatives using a Suzuki protocol

S Vice et al.

JOURNAL OF ORGANIC CHEMISTRY (2001)

Add to Collection
Article Chemistry, Physical

Ion conduction in zwitterionic-type molten salts and their polymers

M Yoshizawa et al.

JOURNAL OF MATERIALS CHEMISTRY (2001)

Add to Collection
Article Chemistry, Organic

Radical and anionic response of N-(bromomethanesulfonyl)-substituted α,α′-bridged piperidine substrates

JD Schloss et al.

JOURNAL OF ORGANIC CHEMISTRY (2000)

Add to Collection
Article Chemistry, Medicinal

Anilides of (R)-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase

GR Bebernitz et al.

JOURNAL OF MEDICINAL CHEMISTRY (2000)

Add to Collection
Article Chemistry, Medicinal

Protease inhibitors:: Synthesis and QSAR study of novel classes of nonbasic thrombin inhibitors incorporating sulfonylguanidine and O-methylsulfonylisourea moieties at p1

CT Supuran et al.

JOURNAL OF MEDICINAL CHEMISTRY (2000)

Add to Collection
Article Chemistry, Medicinal

Novel benzofuran and benzothiophene biphenyls as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties

MS Malamas et al.

JOURNAL OF MEDICINAL CHEMISTRY (2000)

Add to Collection
Article Chemistry, Organic

A practical and efficient preparation of the releasable naphthosultam side chain of a novel anti-MRSA carbapenem

RA Miller et al.

JOURNAL OF ORGANIC CHEMISTRY (2000)

Add to Collection
Article Biochemistry & Molecular Biology

Carbonic anhydrase inhibitors: Inhibition of isozymes I, II and IV by sulfamide and sulfamic acid derivatives

A Scozzafava et al.

JOURNAL OF ENZYME INHIBITION (2000)

Add to Collection
Article Chemistry, Organic

Affinity labelling at the 4-hydroxyl group of N-acetylglucosamine and N-acetylgalactosamine

CJ Moule et al.

SYNTHETIC COMMUNICATIONS (2000)

Add to Collection
Article Chemistry, Multidisciplinary

New and more potent antifungal disulfides

FJ Baerlocher et al.

AUSTRALIAN JOURNAL OF CHEMISTRY (2000)

Add to Collection
Webinars Posters Questions Hubs Funding Journals Papers Connect Collections Reviewers About Us FAQs Mobile App Privacy Policy Terms of Use
© Peeref 2019-2024. All rights reserved.