Journal
MEDICINAL CHEMISTRY
Volume 12, Issue 5, Pages 426-431Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1573406412666151112125345
Keywords
Ferrocene derivative; synthesis; characterization; NMR; XRD; anticancer activity
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Funding
- National Natural Science Foundation of China [21373221]
- open program of Mengchao Hepatobiliary Hospital of Fujian Medical University [2014ZDSY2004]
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A novel structure of ferrocene derivative 1 was synthesized with cyanuric chloride and ferrocenemethanol as starting materials. The synthesized compound was fully characterized using H-1 NMR, C-13 NMR, MS and XRD. Subsequently, the in vitro anticancer effect against A549, HCT116 and MCF-7 cell lines was preliminarily evaluated by the MTT method. The result showed that this compound exhibits good cytotoxic effect on A549, HCT116 and MCF-7 cell lines.
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