Journal
CHEMICAL COMMUNICATIONS
Volume 51, Issue 10, Pages 1866-1869Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc07911f
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Funding
- National Basic Research Program of China (973 Program) [2013CB834701]
- Research Grants Council of Hong Kong [16301614, 604913, 604711, N_HKUST604/14, N_HKUST620/11]
- University Grants Committee of Hong Kong [AoE/P-03/08]
- NHMRC early career fellowship [APP1037798]
- McKenzie Fellowship of the University of Melbourne
- ARC Discovery Early Career Researcher Award [DE120102784]
- NHMRC research fellowship [535014]
- Guangdong Innovative Research Team Program [201101C0105067115]
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We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the alpha-synuclein (alpha-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of alpha-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.
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