☆ 4.7 Article

A metal-phenolic network-assembled nanotrigger evokes lethal ferroptosis via self-supply loop-based cytotoxic reactions

CHEMICAL ENGINEERING JOURNAL (2024)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Multifunctional Protein Hybrid Nanoplatform for Synergetic Photodynamic-Chemotherapy of Malignant Carcinoma by Homologous Targeting Combined with Oxygen Transport

Song-Yu Wu et al.

Summary: A novel multi-functional protein hybrid nanoplatform is designed to address the problems of photodynamic therapy under hypoxic conditions and drug resistance in chemotherapy. This nanoplatform achieves targeted oxygen transport and drug delivery in hypoxic tumors through protein homology recognition, resulting in a more efficient tumor-inhibiting effect compared to traditional photodynamic chemotherapy.

ADVANCED SCIENCE (2023)

Add to Collection

Article Multidisciplinary Sciences

Metal-Phenolic Network-Facilitated Foe-to-Friend Conversion of Melittin for Cancer Immunotherapy with Boosted Abscopal Effect

Yuxin Guo et al.

Summary: In this study, a tannic acid-Fe3+ metal-phenolic network (MPN)-based strategy is developed to convert the cytolytic peptide melittin (Mel) from foe to friend by reducing its hemolytic activity. The strategy uses strong interactions between proteins/peptides and polyphenols to shield Mel's positive charges. Additionally, an immune adjuvant resiquimod (R848) is introduced to enhance immunostimulation. The nanodrug created through this strategy effectively induces immunogenic cell death, stimulates antitumor immunostimulation, and shows potential for cancer treatment.

RESEARCH (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Rigid Shell Decorated Nanodevice with Fe/H2O2 Supply and Glutathione Depletion Capabilities for Potentiated Ferroptosis and Synergized Immunotherapy

Xu Dai et al.

Summary: A rigid metal-polyphenol shell decorated nanodevice ssPPE(Lap)@Fe-TA is constructed to overcome the limitations of ferroptosis therapy. It efficiently internalizes into tumor cells and initiates ferroptosis by disintegrating in the acidic endosome/lysosome. By depleting glutathione and promoting H2O2 release, it inhibits tumor progression through Fe3+-mediated Fenton reaction. Moreover, ssPPE(Lap)@Fe-TA induces a strong antitumor immune response and synergizes with anti-PD-L1 antibody to suppress tumor growth and metastasis.

ADVANCED FUNCTIONAL MATERIALS (2023)

Add to Collection

Review Engineering, Environmental

Engineered anti-cancer nanomedicine for synergistic ferroptosis-immunotherapy

Xinyu Zhang et al.

Summary: Immunotherapy is widely used in clinical practice, but its therapeutic effects on many cancers are poor due to dose-limiting immune responses. The combination of ferroptosis and immunotherapy in cancer nanomedicine provides a new opportunity for selectively triggering tumor immunity and eradicating tumors. Various engineered nanomaterials, including metal oxides, metal-organic frameworks, and liposomes, can improve ferroptosis in tumor cells and mediate antitumor immunity by activating the tumor immune microenvironment.

CHEMICAL ENGINEERING JOURNAL (2023)

Add to Collection

Article Chemistry, Multidisciplinary

Fibronectin-Coated Metal-Phenolic Networks for Cooperative Tumor Chemo-/Chemodynamic/Immune Therapy via Enhanced Ferroptosis-Mediated Immunogenic Cell Death

Yao Xu et al.

Summary: The development of a multifunctional theranostic nanoplatform based on doxorubicin-loaded tannic acid-iron networks is described. The platform shows excellent stability, strong targeting ability, and provides the advantages of cooperative immune therapy through iron-based chemodynamic therapy and doxorubicin chemotherapy.

ACS NANO (2022)

Add to Collection

Article Chemistry, Multidisciplinary

A Triple-Kill Strategy for Tumor Eradication Reinforced by Metal-Phenolic Network Nanopumps

Wei Sang et al.

Summary: This study incorporates a metal-phenolic network into a triple combination therapy to address tumor resistance. The combination therapy effectively suppresses PD-L1 expression and overcomes resistance to the treatment.

ADVANCED FUNCTIONAL MATERIALS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Engineering Radiosensitizer-Based Metal-Phenolic Networks Potentiate STING Pathway Activation for Advanced Radiotherapy

Jie Yan et al.

Summary: This paper proposes a strategy combining radiosensitization and STING pathway activation by fabricating a novel radiosensitizer that releases drugs in a pH-responsive manner. This strategy increases the sensitivity of cancer cells to radiation therapy and promotes immune response, improving the efficacy of cancer radiotherapy.

ADVANCED MATERIALS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Phototheranostic Metal-Phenolic Networks with Antiexosomal PD-L1 Enhanced Ferroptosis for Synergistic Immunotherapy

Lisi Xie et al.

Summary: In this study, phototheranostic metal-phenolic networks were engineered for precise photo thermal therapy. This therapy could relieve exosomal suppression, restore T cells, and enhance ferroptosis. The synergy of photo thermal therapy with antiexosomal PD-L1 evoked potent antitumor immunity and immunological memory against metastatic tumors.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2022)

Add to Collection

Review Medicine, Research & Experimental

Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy

Bin Ji et al.

Summary: Cancer immunotherapy has shown great progress in advanced-stage malignancies, but low response rates and immunosuppressive tumor microenvironments limit its effectiveness. Photodynamic therapy (PDT) can induce immunogenic cell death and enhance immune responses. Recent nanomedicine-based strategies have improved the efficiency of PDT and immunotherapy, and synergistic nanotherapeutics have been used to amplify immune responses. Challenges and future expectations in PDT-driven cancer immunotherapy are discussed.

THERANOSTICS (2022)

Add to Collection

Review Chemistry, Multidisciplinary

Metal Ion-Directed Functional Metal-Phenolic Materials

Huimin Geng et al.

Summary: Metal ions play significant roles in metal-phenolic material engineering by interacting with phenolic compounds and facilitating the assembly of materials with specific and functional properties. This review focuses on the diversity and function of metal ions in metal-phenolic material engineering, discussing different types of interactions and the resulting material properties. Applications and perspectives of metal-phenolic materials are also highlighted.

CHEMICAL REVIEWS (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Dual key co-activated nanoplatform for switchable MRI monitoring accurate ferroptosis-based synergistic therapy

Renye Yue et al.

Summary: A tumor-microenvironment-targeted and co-activated catalytic nanoplatform (CACN) has been developed for specific ferroptosis treatment of cancer cells or tumors. The catalytic activity of CACN can be turned on by dual stimuli of ATP and slight acidity in the tumor microenvironment. The switchable MRI signal of CACN is correlated with reactive oxygen species generation and drug release, allowing for monitoring the therapeutic process.

CHEM (2022)

Add to Collection

Review Cell Biology

Recent progress in ferroptosis: inducers and inhibitors

Yunxi Du et al.

Summary: Ferroptosis is a new iron-dependent form of programmed cell death, closely related to the pathophysiological processes of many diseases. Recent studies have identified key targets and regulators, which are of great significance for related research.

CELL DEATH DISCOVERY (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Mitochondrion, lysosome, and endoplasmic reticulum: Which is the best target for phototherapy?

Yan-Hong Li et al.

Summary: This study successfully synthesized the DSPE-PEG-Ce6 molecule and demonstrated that its dynamic subcellular distribution can accurately assess the efficacy order of specific organelle-targeted PDT. This research provides an ideal model system for accurately evaluating the efficacy of specific organelle-targeted PDT and may promote the development of effective PDT strategies in the future.

JOURNAL OF CONTROLLED RELEASE (2022)

Add to Collection

Article Chemistry, Multidisciplinary

Metal-Phenolic Network-Enabled Lactic Acid Consumption Reverses Immunosuppressive Tumor Microenvironment for Sonodynamic Therapy

Zhan Zhang et al.

Summary: The constructed nanocomplex can remodel the immunosuppressive tumor microenvironment and achieve effective inhibition of tumors through sonodynamic therapy, while alleviating tumor hypoxia and acidic environment.

ACS NANO (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Conquering the Hypoxia Limitation for Photodynamic Therapy

Yilin Wan et al.

Summary: Photodynamic therapy (PDT) is a promising treatment modality due to its high spatiotemporal selectivity, minimal invasiveness, and low systemic toxicity, however, the hypoxic nature of many solid tumors limits its therapeutic effect. Efforts have been made to increase tumor oxygen content and alleviate tumor hypoxia through various strategies developed in the past decade, including delivering exogenous oxygen, generating oxygen in situ, reducing tumor cellular oxygen consumption, regulating the tumor microenvironment, and inhibiting the hypoxia-inducible factor 1 signaling pathway.

ADVANCED MATERIALS (2021)

Add to Collection

Article Engineering, Environmental

Oxidation-sensitive polymeric nanocarrier-mediated cascade PDT chemotherapy for synergistic cancer therapy and potentiated checkpoint blockade immunotherapy

Di Wu et al.

Summary: The study introduced an oxidation-sensitive polyphosphoester (PPE)-based nanocarrier for co-encapsulation of chlorin e6 (Ce6) and docetaxel (Dtxl) to achieve synergistic laryngeal cancer therapy through combined photodynamic therapy and chemotherapy. This approach not only induced cell apoptosis and triggered drug release through a hydrophobic to hydrophilic transition, but also enhanced antitumor immune response and improved the effectiveness of immune checkpoint blockade antibodies against distant tumor growth.

CHEMICAL ENGINEERING JOURNAL (2021)

Add to Collection

Review Chemistry, Inorganic & Nuclear

Oxygen self-sufficient photodynamic therapy

Fangmian Wei et al.

Summary: Photodynamic therapy is a non-invasive treatment for cancers and non-malignant diseases, but some agents are limited by their oxygen-dependent nature in hypoxic solid tumors. Recent advances in oxygen self-sufficient nanomaterials offer opportunities to overcome this challenge and improve the efficacy of PDT in hypoxia.

COORDINATION CHEMISTRY REVIEWS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Polyphenol-Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Yuxin Guo et al.

Summary: Polyphenols, commonly found in plants, have beneficial effects on human health and their use in nanoparticles shows promising potential for various biomedical applications. Their coordination with metal ions forms important complexes with applications in surface modification, bioimaging, drug delivery, and disease treatments. The versatility of polyphenol-containing nanoparticles in different biomedical applications has been demonstrated, with challenges for future research being discussed.

ADVANCED MATERIALS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Renal Clearable Ultrasmall Single-Crystal Fe Nanoparticles for Highly Selective and Effective Ferroptosis Therapy and Immunotherapy

Huan Liang et al.

Summary: This study synthesized ultrasmall single-crystal Fe nanoparticles that showed high activity in inducing tumor cell ferroptosis and immunogenetic cell death in the tumor microenvironment at a low concentration. These nanoparticles effectively suppressed tumor growth, promoted dendritic cell maturation, and triggered T cell response in animal models, and when combined with immune checkpoint blockade therapy, they greatly enhanced the immune response and developed strong immune memory. Furthermore, the nanoparticles were quickly excreted in the kidneys without side effects in normal tissues.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A Robust Oxygen-Carrying Hemoglobin-Based Natural Sonosensitizer for Sonodynamic Cancer Therapy

Meng Yuan et al.

Summary: The study demonstrates that hemoglobin (Hb) as a sonosensitizer shows great potential and has better sensitization efficiency compared to traditional sonosensitizers, effectively avoiding the low ROS quantum yield problem. By integrating with ZIF-8 to form a nanoplatform, it can effectively suppress deep-seated tumors under ultrasound irradiation.

NANO LETTERS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Recent Advances in Metal-Phenolic Networks for Cancer Theranostics

Zhan Zhang et al.

Summary: Nanomedicine integrates different functional materials to customize carriers for increased cancer therapeutic efficacy and reduced off-target toxicity. Metal-phenolic networks (MPNs) have emerged as promising candidates for nanomedicine, utilizing coordination between phenolic ligands and metal ions as multifunctional theranostic nanoplatforms with unique properties such as rapid preparation, negligible cytotoxicity, and pH responsiveness.

SMALL (2021)

Add to Collection

Review Pharmacology & Pharmacy

Photodynamic Therapy Review: Principles, Photosensitizers, Applications, and Future Directions

Jose H. Correia et al.

Summary: Photodynamic therapy (PDT) is a minimally invasive therapeutic modality that selectively targets tumor cells by using photosensitizers and specific light wavelengths. New research on enhanced tumor selectivity of photosensitizers and improved effectiveness of PDT is being conducted, along with exploring new applications of PDT.

PHARMACEUTICS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Delivery Nanomedicine for O2-Economized Photodynamic Tumor Therapy

Lin-Ping Zhao et al.

NANO LETTERS (2020)

Add to Collection

Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Enhanced Ferroptosis by Oxygen-Boosted Phototherapy Based on a 2-in-1 Nanoplatform of Ferrous Hemoglobin for Tumor Synergistic Therapy

Tian Xu et al.

ACS NANO (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

Fulvio Ursini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Add to Collection

Article Chemistry, Multidisciplinary

A Glucose/Oxygen-Exhausting Nanoreactor for Starvation- and Hypoxia-Activated Sustainable and Cascade Chemo-Chemodynamic Therapy

Yuxin Guo et al.

SMALL (2020)

Add to Collection

Article Nanoscience & Nanotechnology

Self-Assembly Protein Superstructures as a Powerful Chemodynamic Therapy Nanoagent for Glioblastoma Treatment

Tao Zheng et al.

NANO-MICRO LETTERS (2020)

Add to Collection

Review Chemistry, Multidisciplinary

Nanomaterials to relieve tumor hypoxia for enhanced photodynamic therapy

Cheng Zhang et al.

NANO TODAY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Au-Hemoglobin Loaded Platelet Alleviating Tumor Hypoxia and Enhancing the Radiotherapy Effect with Low-Dose X-ray

Donglin Xia et al.

ACS NANO (2020)

Add to Collection

Review Nanoscience & Nanotechnology

Application of nanotechnology for enhancing photodynamic therapy via ameliorating, neglecting, or exploiting tumor hypoxia

DanRong Hu et al.

VIEW (2020)

Add to Collection

Review Biochemistry & Molecular Biology

The interaction between ferroptosis and lipid metabolism in cancer

Dingshan Li et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

Add to Collection

Review Biochemical Research Methods

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Giovanni C. Forcina et al.

PROTEOMICS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Luminescent, Oxygen-Supplying, Hemoglobin-Linked Conjugated Polymer Nanoparticles for Photodynamic Therapy

Linye Jiang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Chen Liang et al.

ADVANCED MATERIALS (2019)

Add to Collection

Article Chemistry, Physical

Metal-Phenolic Network-Based Nanocomplexes that Evoke Ferroptosis by Apoptosis: Promoted Nuclear Drug Influx and Reversed Drug Resistance of Cancer

Yuxin Guo et al.

CHEMISTRY OF MATERIALS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Triggered All-Active Metal Organic Framework: Ferroptosis Machinery Contributes to the Apoptotic Photodynamic Antitumor Therapy

Xuan Meng et al.

NANO LETTERS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect

Zhikuan Chen et al.

ACS NANO (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Emerging Strategies of Cancer Therapy Based on Ferroptosis

Zheyu Shen et al.

ADVANCED MATERIALS (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Innovative Strategies for Hypoxic-Tumor Photodynamic Therapy

Xingshu Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection

Review Medicine, Research & Experimental

Photodynamic therapy - mechanisms, photosensitizers and combinations

Stanislaw Kwiatkowski et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Biotechnology & Applied Microbiology

Nanoparticles as carriers for drug delivery in cancer

Ankita Dadwal et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Metal-phenolic networks as a versatile platform to engineer nanomaterials and biointerfaces

Hirotaka Ejima et al.

NANO TODAY (2017)

Add to Collection

Article Chemistry, Multidisciplinary

Hemoglobin-Based Nanoarchitectonic Assemblies as Oxygen Carriers

Yi Jia et al.

ADVANCED MATERIALS (2016)

Add to Collection

Review Chemistry, Multidisciplinary

Nanoparticles in Photodynamic Therapy

Sasidharan Swarnalatha Lucky et al.

CHEMICAL REVIEWS (2015)

Add to Collection

Review Medicine, General & Internal

Photodynamic Therapy: Current Status and Future Directions

Ludmil Benov

MEDICAL PRINCIPLES AND PRACTICE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

CELL (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

CELL (2012)

Add to Collection

Article Oncology

Photodynamic Therapy of Cancer: An Update

Patrizia Agostinis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

Add to Collection

© Peeref 2019-2024. All rights reserved.