Magnetic field-boosted electrocatalytic process for the dissociation of Alzheimer's β-amyloid aggregates

Article Nanoscience & Nanotechnology

Linnaeite Mineral for NIR Light-Triggered Disruption of Alzheimer's Pore-Forming Aβ Oligomers

Jinhyeong Jang et al.

Summary: A study has found that linnaeite mineral can dissociate Alzheimer's beta-amyloid oligomers under near-infrared light irradiation, suggesting its potential as a drug for reducing AD pathology.

ACS APPLIED MATERIALS & INTERFACES (2023)

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Article Materials Science, Multidisciplinary

Water-Stable and Photo-Patternable Siloxane-Encapsulated Upconversion Nanoparticles toward Flexible Near-Infrared Phototransistors

Injun Lee et al.

Summary: Upconversion nanoparticles (UCNPs) are encapsulated with a siloxane polymer (UCNP@SiOx) through a sol-gel process, enabling water stability and photo-patternability. The UCNP@SiOx demonstrates no significant decrease in upconversion photoluminescence (PL) intensities and PL decay time after immersion in water, and is found to be non-toxic. Integration of UCNP@SiOx with MoS2 phototransistors results in enhanced responsivity and specific detectivity, as well as excellent mechanical durability. This work introduces a facile synthesis method for water-stable and photo-patternable siloxane-encapsulated UCNPs and a strategy for fabricating high-performance flexible NIR phototransistors through wavelength conversion.

ADVANCED OPTICAL MATERIALS (2023)

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Article Chemistry, Physical

Magnetic Field-Enhanced Electrocatalytic Oxygen Evolution on a Mixed-Valent Cobalt-Modulated LaCoO3 Catalyst

Ting Wang et al.

Summary: This work proposes a novel mixed-valent cobalt modulation strategy to enhance the electrocatalytic oxygen evolution reaction (OER) performance of perovskite LaCoO3 oxide. The optimized catalyst with Co2+/Co3+ ratio of 1.98% exhibits the best OER activity, and the use of an external magnetic field further enhances the performance. These findings may provide a promising strategy for further enhancement of OER performance.

CHEMPHYSCHEM (2023)

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Article Chemistry, Multidisciplinary

NIR-II Hydrogen-Bonded Organic Frameworks (HOFs) Used for Target-Specific Amyloid-β Photooxygenation in an Alzheimer's Disease Model

Haochen Zhang et al.

Summary: A hydrogen-bonded organic framework (HOF)-based NIR-II photooxygenation catalyst has shown potential in inhibiting beta-amyloid self-assembly, leading to improved symptoms in Alzheimer's disease.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022)

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Article Biotechnology & Applied Microbiology

The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

Eric Karran et al.

Summary: Clinical trial data for drugs targeting Aβ in Alzheimer's disease suggest that reducing amyloid plaque to a low level may reveal significant clinical benefit, but there may be a time lag between plaque removal and observable clinical benefit. The speed of amyloid removal from the brain by a potential therapy will be crucial in demonstrating clinical benefit in a clinical trial setting.

NATURE REVIEWS DRUG DISCOVERY (2022)

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Article Chemistry, Physical

Magnetic field assisted electrocatalytic oxygen evolution reaction of nickel-based materials

Yuanyuan Zhang et al.

Summary: The study reveals that the magnetoresistance effect caused by spin electron scattering dominates the apparent electrocatalytic activity in the magnetic field-assisted oxygen evolution reaction process. Additionally, the magnetic field-induced spin-polarized kinetics are more distinct when the first electron transfer step is the rate-determining step of the OER, especially for nickel. These findings provide insights into the role of magnetic effects in electrochemical reactions and may aid in the rational design of magnetic effect catalysts.

JOURNAL OF MATERIALS CHEMISTRY A (2022)

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Article Chemistry, Multidisciplinary

Reducing Valence States of Co Active Sites in a Single-Atom Nanozyme for Boosted Tumor Therapy

Hui Wang et al.

Summary: This study presents the construction of biocompatible and trackable-imaging single-atom nanozymes (SAzymes) with efficient catalytic activities. The enzyme-like activity was enhanced by tenfold by varying the calcination conditions. Moreover, the Co/TiO2 SAzymes exhibited good intrinsic biocompatibility and excellent tolerance toward the biological medium, while the hollow structure facilitated the loading of drugs and imaging agents for image-guided chemo-chemodynamic therapy.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Article Engineering, Environmental

Hydroxyl radicals in anodic oxidation systems: generation, identification and quantification

Jiangzhou Xie et al.

Summary: Anodic oxidation is a promising treatment technology for removing organic pollutants from wastewaters. Hydroxyl radicals are the primary species used for oxidizing organics. This review discusses the methods of identifying hydroxyl radicals, debates on the validity of experimental results, and quantification methods. It also highlights the generation mechanisms of hydroxyl radicals and their utilization in electrochemical reactors. The key challenges for anodic oxidation technology are identified as eliminating errors in identification, establishing effective quantification methods, developing cost-effective anode materials, and optimizing reactor designs for maximum utilization efficiency of hydroxyl radicals.

WATER RESEARCH (2022)

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Article Multidisciplinary Sciences

Magnetoelectric dissociation of Alzheimer's β-amyloid aggregates

Jinhyeong Jang et al.

Summary: This study discovered the dissociation function of magnetoelectric nanomaterials for Aβ aggregates under low-frequency magnetic field and confirmed their alleviating effect on Aβ-associated toxicity. The high efficacy of BCFO nanoparticles for the clearance of Aβ plaques in an AD mouse model was also demonstrated, indicating the potential of magnetoelectric materials for future AD treatment using magnetic fields.

SCIENCE ADVANCES (2022)

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Article Nanoscience & Nanotechnology

Siloxane Hybrid Material-Encapsulated Highly Robust Flexible μLEDs for Biocompatible Lighting Applications

Han Eol Lee et al.

Summary: This study reports the development of highly robust flexible micro-light-emitting diodes (f-H mu LEDs) using a siloxane-based organic-inorganic hybrid material. The f-H mu LEDs demonstrate outstanding mechanical, thermal, and environmental stabilities, making them suitable for flexible display and biomedical device applications. The study also demonstrates the white light emission capabilities of the f-H mu LEDs through quantum dot-based color conversion.

ACS APPLIED MATERIALS & INTERFACES (2022)

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Article Chemistry, Multidisciplinary

Metal-Organic Framework-Derived Carbon as a Photoacoustic Modulator of Alzheimer's Structure

Jinhyeong Jang et al.

Summary: In this study, the photoacoustic dissociation of beta-amyloid (Afl) aggregates, a hallmark of Alzheimer's disease, by metal-organic framework derived carbon (MOFC) was reported. MOFC exhibited near-infrared (NIR) light-responsive photoacoustic characteristic and successfully transformed toxic Afl aggregates into nontoxic debris.

ACS NANO (2022)

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Article Chemistry, Multidisciplinary

Direct Magnetic Reinforcement of Electrocatalytic ORR/OER with Electromagnetic Induction of Magnetic Catalysts

Jianhua Yan et al.

Summary: The carbon-based magnetic catalytic nanocages can enhance oxygen catalytic activity under an external magnetic field, improving catalytic efficiency significantly. Compared to commercial catalysts, the magnetic catalyzed Zn-air batteries show higher capacities and longer durability, pointing towards a promising strategy of utilizing electromagnetic induction to boost oxygen catalysis.

ADVANCED MATERIALS (2021)

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Review Clinical Neurology

Technology of deep brain stimulation: current status and future directions

Joachim K. Krauss et al.

Summary: Deep brain stimulation (DBS) is a neurosurgical procedure that allows targeted circuit-based neuromodulation and is now commonly used for the treatment of movement disorders such as Parkinson's disease, tremor, and dystonia. Advances in engineering and imaging technologies are expected to enhance the efficacy and tolerability of DBS procedures in the future.

NATURE REVIEWS NEUROLOGY (2021)

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Article Chemistry, Physical

Enhanced electrocatalysis of NiMnIn Heusler alloy films for hydrogen evolution reaction by magnetic field

Jiawei Chen et al.

Summary: A Ni43Mn32In25 (NiMnIn) Heusler alloy film with highly efficient hydrogen evolution reaction (HER) activity was developed and deposited on porous Ni foam by pulsed laser deposition. The NiMnIn film exhibited ferromagnetic properties at room temperature and showed significantly enhanced HER activity when a magnetic field was applied. This work suggests that Heusler alloys can be efficient HER active electrodes with magnetic field sensitivity for magnetoelectrochemistry applications.

JOURNAL OF ALLOYS AND COMPOUNDS (2021)

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Article Chemistry, Physical

Oxygen evolution reaction over catalytic single-site Co in a well-defined brookite TiO2 nanorod surface

Chang Liu et al.

Summary: Efficient single-site Co catalysts supported on well-defined TiO2 nanorods were found to exhibit excellent performance in the oxygen evolution reaction (OER), with turnover frequencies among the highest reported for Co-based catalysts. Computational and experimental results showed good agreement in describing the catalytic reaction kinetics and mechanisms.

NATURE CATALYSIS (2021)

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Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

Summary: Alzheimer's disease is projected to see a significant increase in prevalence in the future, with genetics playing a key role. Novel biomarkers and lifestyle-based prevention trials show promising therapeutic potential. Promising pharmacological treatments are advancing in clinical trials, targeting amyloid beta, tau, and inflammation.

LANCET (2021)

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Article Nanoscience & Nanotechnology

Near-Infrared-Active Copper Molybdenum Sulfide Nanocubes for Phonon-Mediated Clearance of Alzheimer's β-Amyloid Aggregates

Jinhyeong Jang et al.

Summary: This study investigates the efficacy of a novel biocompatible ternary chalcogenide nanomaterial, copper molybdenum sulfide (CMS) nanocubes, in dissociating neurotoxic Alzheimer's beta-amyloid (A beta) aggregates under near-infrared (NIR) light. Results demonstrate that NIR-excited CMS nanocubes effectively disassemble A beta fibrils, alleviating their toxicity and reducing A beta plaques in AD mouse brains without causing macroscopic damage. This suggests the potential therapeutic use of CMS nanocubes for Alzheimer's Disease mitigation.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Biomedical

Near-infrared target enhanced peripheral clearance of amyloid-β in Alzheimer's disease model

Mengmeng Ma et al.

Summary: A near-infrared regulated platform was constructed for Aβ clearance, addressing challenges by enhancing plasma Aβ enrichment, preventing Aβ aggregation, and facilitating hepatic clearance. In vivo studies demonstrated efficient reduction of brain Aβ burden and reversal of memory deficits in mice.

BIOMATERIALS (2021)

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Review Biochemistry & Molecular Biology

The Amyloid-β Pathway in Alzheimer's Disease

Harald Hampel et al.

Summary: Breakthroughs in molecular medicine have highlighted the significance of the amyloid-beta pathway in the pathophysiology of Alzheimer's disease. Established biochemical alterations of the A beta cycle serve as promising targets for the development of disease-modifying therapies. Research indicates a crucial role of A beta pathway dyshomeostasis in the dynamics of AD pathophysiology, supporting the development of A beta-targeting therapeutic strategies for early treatment of AD.

MOLECULAR PSYCHIATRY (2021)

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Review Clinical Neurology

Amyloid-β: a potential link between epilepsy and cognitive decline

Michele Romoli et al.

Summary: People with epilepsy have an increased risk of dementia, and the relationship between epilepsy and cognitive decline remains controversial, with evidence suggesting that A beta may be a shared pathway between the two conditions.

NATURE REVIEWS NEUROLOGY (2021)

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Article Multidisciplinary Sciences

Spin pinning effect to reconstructed oxyhydroxide layer on ferromagnetic oxides for enhanced water oxidation

Tianze Wu et al.

Summary: This study introduces a strategy of spin pinning to increase the spin alignment in paramagnetic oxyhydroxides, aiming to enhance the OER activity, and confirms the spin effect in the rate-limiting OER step.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Physical

Decreasing the Energy Consumption of the CO2 Electrolysis Process Using a Magnetic Field

Saket S. Bhargava et al.

Summary: This study reduces the energy consumption of CO2 electrolysis by using a NiFe-based bimetallic catalyst and applying a magnetic field. Power savings ranging from 7% to 6496% are achieved in a gas diffusion electrode-based flow electrolyzer, with a maximum CO partial current density of -565 mA/cm(2) reached.

ACS ENERGY LETTERS (2021)

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Article Chemistry, Multidisciplinary

Enhancing the efficiency of the hydrogen evolution reaction utilising Fe3P bulk modified screen-printed electrodes via the application of a magnetic field

Jack. P. Hughes et al.

Summary: This study optimises Fe3P bulk modified screen-printed electrochemical platforms for the hydrogen evolution reaction by utilising different Fe3P variants and increasing the mass percentage of Fe3P. Additionally, the application of a variable weak magnetic field enhances the current density output by 56%.

RSC ADVANCES (2021)

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Article Chemistry, Physical

Influence of Anodization-Electrolyte Aging on the Photocatalytic Activity of TiO2 Nanotube Arrays

Luka Suhadolnik et al.

JOURNAL OF PHYSICAL CHEMISTRY C (2020)

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Article Chemistry, Physical

Effective Magnetic Field Regulation of the Radical Pair Spin States in Electrocatalytic CO2 Reduction

Haiping Pan et al.

JOURNAL OF PHYSICAL CHEMISTRY LETTERS (2020)

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Full activation pattern mapping by simultaneous deep brain stimulation and fMRI with graphene fiber electrodes

Siyuan Zhao et al.

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Magnetic Enhancement for Hydrogen Evolution Reaction on Ferromagnetic MoS2 Catalyst

Wenda Zhou et al.

NANO LETTERS (2020)

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Piezoelectric materials for ultrasound-driven dissociation of Alzheimer's β-amyloid aggregate structure

Jinhyeong Jang et al.

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Use of magnetic fields in electrochemistry: A selected review

Vivien Gatard et al.

CURRENT OPINION IN ELECTROCHEMISTRY (2020)

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Photomodulating Carbon Dots for Spatiotemporal Suppression of Alzheimer's β-Amyloid Aggregation

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Regulation of oxygen reduction reaction by the magnetic effect of L10-PtFe alloy

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APPLIED CATALYSIS B-ENVIRONMENTAL (2020)

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Self-Protecting Biomimetic Nanozyme for Selective and Synergistic Clearance of Peripheral Amyloid-β in an Alzheimer's Disease Model

Mengmeng Ma et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Recent Advances in Magnetic Field-Enhanced Electrocatalysis

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The neuroprotective effect of deep brain stimulation at nucleus basalis of Meynert in transgenic mice with Alzheimer's disease

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Deep brain stimulation induced normalization of the human functional connectome in Parkinson's disease

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Magnetic field enhancing electrocatalysis of Co3O4/NF for oxygen evolution reaction

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Activating Inert ZnO by Surface Cobalt Doping for Efficient Water Oxidation in Neutral Media

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Multivalent Polyaspartamide Cross-Linker for Engineering Cell-Responsive Hydrogels with Degradation Behavior and Tunable Physical Properties

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Magnetic field-boosted electrocatalytic process for the dissociation of Alzheimer's β-amyloid aggregates

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