4.7 Article

Enhanced scale-up performance on residence time distribution by integrated microcapillaries with high size uniformity

Related references

Note: Only part of the references are listed.
Article Engineering, Environmental

Performance of continuous-flow micro-reactors with curved geometries. Experimental and numerical analysis

Christian Fernandez-Maza et al.

Summary: We conducted a comprehensive analysis of reactants mixing and reaction rate in liquid phase flow micro-reactors with curved geometries. A mathematical model was developed using computational fluid dynamics techniques to predict the mixing efficiency and reaction rate. The results showed that mixing is promoted through the formation of Dean vortices by reducing the radius of curvature and extending the curve, leading to improved overall performance of the micro-reactor.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Engineering, Environmental

Fast prototyping using 3D printed templates and flexible fluoropolymer microcapillary films offers enhanced micromixing in immobilised (bio) catalytic reactions

Kirandeep K. Gill et al.

Summary: This study presents a novel approach in fabricating inexpensive non-linear microstructure prototypes using a flexible fluoropolymer microcapillary film and 3D printed templates, which enhance mass transfer efficiency in microreactors. By evaluating different micromixer structures and experimental validation, significant insights into fluid flow distribution were gained.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Engineering, Chemical

Residence time distribution in reactive and non-reactive flow systems in micro and millidevices

Joao L. da Silva et al.

Summary: This research evaluated the Residence Time Distribution of three microdevice designs in different flow conditions, showing that MTB and G1 devices had higher oil conversions and biodiesel throughputs in biodiesel synthesis.

CHEMICAL ENGINEERING SCIENCE (2022)

Article Engineering, Environmental

Advanced petascale simulations of the scaling up of mixing limited flow processes for materials synthesis

S. Glockner et al.

Summary: The paper focuses on the use of petascale simulations to address the open-ended problem of scaling-up continuous flow processes in microfluidics. High fidelity Direct Numerical Simulations are performed to increase production rate while maintaining mixing quality.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Engineering, Environmental

Design, optimization and scale-up of a new micromixer design based on plate column for organic synthesis

Harrson S. Santana et al.

Summary: This paper introduces a methodology for designing, optimizing, and rapidly prototyping a new micromixer inspired by plate column tray. It utilizes CAD modeling, Design of Experiments (DoE), statistical methods, and numerical simulations to optimize the geometry and scale-up the device. The effects of channel width and static elements on fluid mixing performance are evaluated, and the optimal configuration is determined through statistical analysis. The microdevice shows high mixing efficiency and low pressure drops, and it is also successfully scaled-up and used for experimental synthesis.

CHEMICAL ENGINEERING JOURNAL (2022)

Article Materials Science, Multidisciplinary

Precise Control of Microcapillary Size in Microcapillary Films by Liquid-Assisted Extrusion

Junfeng Liu et al.

Summary: This study presents a new method to precisely adjust the size of microcapillaries by liquid-assisted extrusion, improving the size uniformity and facilitating the applications of MCFs in droplet microfluidics and biotechnologies.

MACROMOLECULAR MATERIALS AND ENGINEERING (2022)

Article Chemistry, Multidisciplinary

Synthesis of Lobeglitazone intermediates seeking for continuous drug production in flow capillary microreactor

Renan Rodrigues de Oliveira Silva et al.

Summary: Continuous flow synthesis in microreactors is replacing traditional batch processes in the chemical-pharmaceutical industry to reduce the time for new drugs to enter the market. This study successfully transposed the synthesis of Lobeglitazone from batch to flow process in a microreactor and determined the reaction kinetics of each step through experiments.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2022)

Article Biochemical Research Methods

Label-free 1D microfluidic dipstick counting of microbial colonies and bacteriophage plaques

Sultan Ilayda Donmez et al.

Summary: Counting viable bacterial cells and functional bacteriophage is crucial in microbiology research and applications. This study presents a rapid and simple method for counting colony forming units (CFU) and plaque forming units (PFU) using dip-stick microfluidic strips combined with digital imaging. The results obtained using this method showed full quantitative agreement with traditional solid agar Petri dish counting, but with a significantly reduced time. The innovation of 1-dimensional colony counting in microfluidics provides new insights into colony growth and has potential applications in microbial analysis.

LAB ON A CHIP (2022)

Article Engineering, Environmental

Mixing performance and continuous production of nanomaterials in an advanced-flow reactor

Mei Yang et al.

Summary: The study conducted continuous synthesis of Ag nanoparticles using the Corning Advanced-Flow Reactor (AFR) and optimized mixing characteristics by controlling flow rate ratio and total flow rate, finding significant effects on the average particle size and particle size distribution of Ag NPs.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Engineering, Environmental

Microcapillary film reactor outperforms single-bore mesocapillary reactors in continuous flow chemical reactions

Kirandeep K. Gill et al.

Summary: The study compared the performance of capillary reactors with different diameters in continuous flow reactions, and found that using multiple parallel small-bore capillaries is a more effective strategy than increasing the diameter of a single large bore, achieving more ideal flow characteristics.

CHEMICAL ENGINEERING JOURNAL (2021)

Article Chemistry, Multidisciplinary

Gravity-Driven Microfluidic Siphons: Fluidic Characterization and Application to Quantitative Immunoassays

Nuno M. Reis et al.

Summary: A range of biosensing techniques, including immunoassays, are used for quantitation of analytes in biological samples. High analytical performance is linked to the use of reagent and washing steps, which can be challenging to deliver in point-of-care testing without a high level of fluidic control.

ACS SENSORS (2021)

Article Materials Science, Multidisciplinary

Improved Size Uniformity of Microcapillaries in Microcapillary Films by Separate Gas Injection

Junfeng Liu et al.

Summary: This paper investigates the mechanisms leading to uneven microcapillary dimensions in traditional MCFs with equal gas pressures in all channels, and improves the size uniformity of microcapillaries by separately injecting gas into different channels, providing new possibilities for generating highly monodisperse microdroplets.

MACROMOLECULAR MATERIALS AND ENGINEERING (2021)

Article Chemistry, Analytical

Modern microfluidic approaches for determination of ions

Huanhuan Shi et al.

Summary: The study focuses on recent methods of ion measurement using microfluidic devices, highlighting potential applications in sample treatment, ion chelating mechanisms, and ion detection strategies, with promising developments in water quality monitoring, healthcare diagnostic testing, and portable device technologies.

MICROCHEMICAL JOURNAL (2021)

Article Chemistry, Multidisciplinary

Antibody Surface Coverage Drives Matrix Interference in Microfluidic Capillary Immunoassays

Ana Barbosa et al.

Summary: This study conducted a systematic analysis using hundreds of actual microfluidic immunoassay fluoropolymer strips to investigate matrix interference in microflow systems. The experiment revealed that the key factor affecting serum matrix interference is capillary antibody surface coverage. A new approach for eliminating and/or minimizing serum matrix interference was proposed, focusing on antibody surface coverage and sample incubation times.

ACS SENSORS (2021)

Review Chemistry, Analytical

Applications of microcapillary films in bioanalytical techniques

Junfeng Liu et al.

Summary: Microcapillary film (MCF) is a plastic film with parallel microcapillaries, offering wide potential applications in bioanalytical techniques. By modifying its surface, MCF can realize various bioanalytical functions, such as protein chromatography and cancer biomarker detection. In the future, MCFs may have broader applications in bioanalytical techniques.

ANALYST (2021)

Review Chemistry, Multidisciplinary

Scaling continuous API synthesis from milligram to kilogram: extending the enabling benefits of micro to the plant

Mateo Berton et al.

JOURNAL OF FLOW CHEMISTRY (2020)

Article Engineering, Environmental

The role of flow features and chemical kinetics on the reaction yield in a T-shaped micro-reactor

Alessandro Mariotti et al.

CHEMICAL ENGINEERING JOURNAL (2020)

Article Biochemical Research Methods

Electro-coalescence in step emulsification: dynamics and applications

Xing Huang et al.

LAB ON A CHIP (2020)

Article Engineering, Environmental

Study of a toroidal-helical pipe as an innovative static mixer in laminar flows

Chenguang Zhang et al.

CHEMICAL ENGINEERING JOURNAL (2019)

Article Chemistry, Physical

Investigation of microfluidic co-flow effects on step emulsification: Interfacial tension and flow velocities

Jiaoyuan Lian et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2019)

Article Polymer Science

The Influence of Residence Time Distribution on Continuous-Flow Polymerization

Marcus H. Reis et al.

MACROMOLECULES (2019)

Article Biochemical Research Methods

Development of a disposable micro-capillary film grafted with peptide ligands for immunoadsorption

Jiawen Li et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2019)

Article Chemistry, Physical

Investigation of microfluidic co-flow effects on step emulsification: Wall contact angle and critical dimensions

Jiaoyuan Lian et al.

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS (2019)

Article Engineering, Environmental

Suspension flow behavior and particle residence time distribution in helical tube devices

Lukas Hohmann et al.

CHEMICAL ENGINEERING JOURNAL (2019)

Article Biophysics

Microfluidic smartphone quantitation of Escherichia coli in synthetic urine

Isabel P. Alves et al.

BIOSENSORS & BIOELECTRONICS (2019)

Article Chemistry, Applied

Characterization of Milli- and Microflow Reactors: Mixing Efficiency and Residence Time Distribution

Sven R. L. Gobert et al.

ORGANIC PROCESS RESEARCH & DEVELOPMENT (2017)

Article Biotechnology & Applied Microbiology

Photo inactivation of virus particles in microfluidic capillary systems

Yudan Ren et al.

BIOTECHNOLOGY AND BIOENGINEERING (2016)

Article Biochemical Research Methods

Lab on a stick: multi-analyte cellular assays in a microfluidic dipstick

Nuno M. Reis et al.

LAB ON A CHIP (2016)

Review Biochemical Research Methods

Fundamentals and applications of inertial microfluidics: a review

Jun Zhang et al.

LAB ON A CHIP (2016)

Article Nanoscience & Nanotechnology

Novel prototyping method for microfluidic devices based on thermoplastic polyurethane microcapillary film

Zheyun Xu et al.

MICROFLUIDICS AND NANOFLUIDICS (2016)

Article Engineering, Environmental

Scale-up concept of single-channel microreactors from process development to industrial production

Norbert Kockmann et al.

CHEMICAL ENGINEERING JOURNAL (2011)

Article Biochemical Research Methods

Fast cation-exchange separation of proteins in a plastic microcapillary disc

N. J. Darton et al.

JOURNAL OF CHROMATOGRAPHY A (2011)

Article Biochemical Research Methods

Thermal mixing of two miscible fluids in a T-shaped microchannel

Bin Xu et al.

BIOMICROFLUIDICS (2010)

Article Engineering, Environmental

Evaluation of the mixing performance of three passive micromixers

Shakhawat Hossain et al.

CHEMICAL ENGINEERING JOURNAL (2009)

Article Engineering, Environmental

Modelling of the residence time distribution in micromixers

D. Boskovic et al.

CHEMICAL ENGINEERING JOURNAL (2008)

Article Engineering, Chemical

Scaling-up and -down in a nature-inspired way

MO Coppens

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH (2005)

Article Materials Science, Multidisciplinary

Hollow microcapillary arrays in thin plastic films

B Hallmark et al.

ADVANCED ENGINEERING MATERIALS (2005)