4.7 Article

Fe3S4 nanozyme inhibits tumor growth by synergistic effects of ferroptosis and apoptosis

Related references

Note: Only part of the references are listed.
Article Chemistry, Multidisciplinary

Self-Adaptive Single-Atom Catalyst Boosting Selective Ferroptosis in Tumor Cells

Fangfang Cao et al.

Summary: A self-adaptive ferroptosis platform has been developed by engineering a DNA modulator onto the surface of single-atom nanozymes, enabling selective and safe antitumor response and promoting the development of selective cancer therapy.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Guiding Transition Metal-Doped Hollow Cerium Tandem Nanozymes with Elaborately Regulated Multi-Enzymatic Activities for Intensive Chemodynamic Therapy

Shuming Dong et al.

Summary: The authors developed a hollow mesoporous Mn/Zr-co-doped CeO2 tandem nanozyme (PHMZCO-AT) with regulated multi-enzymatic activities to disrupt the H2O2 homeostasis, achieve intensive NCDT, and induce tumor apoptosis and death. The nanozyme catalyzes the conversion of superoxide anion into H2O2 in the tumor region and inhibits the off-target decomposition of H2O2. The elevated H2O2 is then converted into toxic hydroxyl radicals, leading to tumor cell death.

ADVANCED MATERIALS (2022)

Article Chemistry, Multidisciplinary

Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death

Feng Wu et al.

Summary: The nanomedicine developed in this study integrates nanocarriers and clinical drugs, exhibiting peroxidase mimicking activities and depleting glutathione in the tumor microenvironment, promoting reactive oxygen species-mediated tumor catalytic therapy, and restoring the chemical sensitivity of oxaliplatin, playing an important role in apoptosis and ferroptosis of tumor cells.

ACS NANO (2022)

Article Chemistry, Multidisciplinary

Cyclodextrin-Derived ROS-Generating Nanomedicine with pH-Modulated Degradability to Enhance Tumor Ferroptosis Therapy and Chemotherapy

Meng Xu et al.

Summary: In this study, pH-sensitive nanoparticles were used to deliver dihydroartemisinin (DHA) for tumor therapy in multiple ways. The nanoparticles generate lethal oxidants in the tumor microenvironment and induce cancer cell death through ferroptosis. This strategy differs from traditional approaches and exhibits efficient anticancer efficacy.

SMALL (2022)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Chemistry, Multidisciplinary

High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis-Ferroptosis Synergistic Tumor Therapy

Xiangqin Meng et al.

Summary: The pyrite peroxidase nanozyme demonstrates ultra-high affinity for H2O2 and possesses intrinsic glutathione oxidase-like activity, resulting in abundant production of (OH)-O-center dot and depletion of reduced glutathione, inducing apoptosis and ferroptosis of tumor cells. It shows potential for effective therapeutic application in tumor catalytic therapy.

ACS NANO (2021)

Article Biochemistry & Molecular Biology

Fibroblast growth factor 21 attenuates iron overload-induced liver injury and fibrosis by inhibiting ferroptosis

Aimin Wu et al.

Summary: Iron overload-induced ferroptosis in hepatocytes is promoted by excessive HO-1 expression, while FGF21 protein can protect against this process by inhibiting ferroptosis and preventing liver damage. These findings suggest that activating FGF21 could be an effective strategy for potential treatment of iron overload-induced ferroptosis-related diseases like hereditary haemochromatosis.

REDOX BIOLOGY (2021)

Review Chemistry, Multidisciplinary

Recent Advances in Nanostrategies Capable of Overcoming Biological Barriers for Tumor Management

Da Huo et al.

ADVANCED MATERIALS (2020)

Article Chemistry, Multidisciplinary

An Enzyme-Mimicking Single-Atom Catalyst as an Efficient Multiple Reactive Oxygen and Nitrogen Species Scavenger for Sepsis Management

Fangfang Cao et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Biodegradation-Mediated Enzymatic Activity-Tunable Molybdenum Oxide Nanourchins for Tumor-Specific Cascade Catalytic Therapy

Xi Hu et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Bioinspired Construction of a Nanozyme-Based H2O2 Homeostasis Disruptor for Intensive Chemodynamic Therapy

Yanjuan Sang et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Article Chemistry, Multidisciplinary

Semiconducting Polycomplex Nanoparticles for Photothermal Ferrotherapy of Cancer

Shasha He et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Article Chemistry, Multidisciplinary

Immunomodulation-Enhanced Nanozyme-Based Tumor Catalytic Therapy

Bolong Xu et al.

ADVANCED MATERIALS (2020)

Review Pharmacology & Pharmacy

Updates on the applications of iron-based nanoplatforms in tumor theranostics

Wenhao Wang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Chemistry, Multidisciplinary

Nanozyme-based catalytic theranostics

Yanan Zhang et al.

RSC ADVANCES (2020)

Review Chemistry, Multidisciplinary

Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications

Yanyan Huang et al.

CHEMICAL REVIEWS (2019)

Article Nanoscience & Nanotechnology

FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels

Vicenta Trujillo-Alonso et al.

NATURE NANOTECHNOLOGY (2019)

Review Oncology

Targeting Ferroptosis to Iron Out Cancer

Behrouz Hassannia et al.

CANCER CELL (2019)

Article Chemistry, Multidisciplinary

Recent Progress in Ferroptosis Inducers for Cancer Therapy

Chen Liang et al.

ADVANCED MATERIALS (2019)

Article Chemistry, Multidisciplinary

Nanocatalytic Tumor Therapy by Biomimetic Dual Inorganic Nanozyme-Catalyzed Cascade Reaction

Shanshan Gao et al.

ADVANCED SCIENCE (2019)

Review Biochemistry & Molecular Biology

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

Matthew Dodson et al.

REDOX BIOLOGY (2019)

Article Chemistry, Multidisciplinary

Nanozyme Decorated Metal-Organic Frameworks for Enhanced Photodynamic Therapy

Yan Zhang et al.

ACS NANO (2018)

Article Oncology

Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis

Ling-Chu Chang et al.

CANCER LETTERS (2018)

Review Biochemistry & Molecular Biology

The Roles of NRF2 in Modulating Cellular Iron Homeostasis

Michael John Kerins et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

Article Multidisciplinary Sciences

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

Matthew J. Hangauer et al.

NATURE (2017)

Article Multidisciplinary Sciences

H2O2-responsive liposomal nanoprobe for photoacoustic inflammation imaging and tumor theranostics via in vivo chromogenic assay

Qian Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Multidisciplinary

Optimization of Fe3O4 nanozyme activity via single amino acid modification mimicking an enzyme active site

Kelong Fan et al.

CHEMICAL COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Chemistry, Multidisciplinary

Graphene Oxide: Intrinsic Peroxidase Catalytic Activity and Its Application to Glucose Detection

Yujun Song et al.

ADVANCED MATERIALS (2010)

Review Oncology

Pathways of apoptotic and non-apoptotic death in tumour cells

H Okada et al.

NATURE REVIEWS CANCER (2004)