Functionalized Tumor Cell Membrane-Camouflaged Photo-Activatable Nanoparticle for Spatiotemporal Antitumor Therapy

Article Chemistry, Multidisciplinary

Branched Polymer-Based Redox/Enzyme-Activatable Photodynamic Nanoagent to Trigger STING-Dependent Immune Responses for Enhanced Therapeutic Effect

Qiang Luo et al.

Summary: Combining photodynamic therapy with AZD2281, a TME-activatable photodynamic nanoagent was designed to induce immune responses in tumors, showing potential for anti-cancer treatment.

ADVANCED FUNCTIONAL MATERIALS (2022)

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Review Chemistry, Multidisciplinary

Biomembrane-Functionalized Micromotors: Biocompatible Active Devices for Diverse Biomedical Applications

Fangyu Zhang et al.

Summary: Cell membrane-functionalized micromotors have attracted considerable interest for biomedical applications due to their biofunctional, versatile, and adaptive capabilities. This new class of micromotors demonstrates enhanced performance in complex biological environments, showing potential in advancing micromotor research.

ADVANCED MATERIALS (2022)

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Article Multidisciplinary Sciences

Bacterial gasdermins reveal an ancient mechanism of cell death

Alex G. Johnson et al.

Summary: Gasdermin proteins play important roles in immune regulation and induction of cell death in human cells by forming membrane pores. Similar proteins encoded by bacteria have been found to defend against phages and execute cell death.

SCIENCE (2022)

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Review Engineering, Environmental

Advances in smart mesoporous carbon nanoplatforms for photothermal-enhanced synergistic cancer therapy

Shuaipeng Feng et al.

Summary: Mesoporous carbon nanoparticles and their derivatives have been extensively studied in photothermal therapy for cancer treatment due to their unique structure and excellent photothermal conversion efficiency. The current research focuses on the application of these nanoparticles in multimodal therapies and the development of low-power efficient photothermal therapy.

CHEMICAL ENGINEERING JOURNAL (2022)

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Article Engineering, Biomedical

Biomimetic smart mesoporous carbon nanozyme as a dual-GSH depletion agent and O 2 generator for enhanced photodynamic therapy

Junya Lu et al.

Summary: In this study, a smart mesoporous carbon nanozyme was designed for dual-mode imaging-guided photodynamic therapy (PDT) and photothermal therapy (PTT). By depleting glutathione and generating oxygen, it effectively destroyed the antioxidant system of tumors and improved the therapeutic efficacy.

ACTA BIOMATERIALIA (2022)

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Review Chemistry, Inorganic & Nuclear

Recent trends of mesoporous silica-based nanoplatforms for nanodynamic therapies

Qingqing Xu et al.

Summary: Nanodynamic therapies using nanosensitizers triggered by various activators or reactions in tumor microenvironment have emerged as attractive strategies for treating deep-seated tumors. Mesoporous silica nanoparticles (MSNs) and MSNs-based hybrid nanoparticles are promising candidates for nanodynamic therapies due to their large surface area, high pore volume, biosafety, and easy surface modification. This review summarizes the antitumor mechanisms and latest progress in the construction, modification, and application of MSNs-based nanodynamic therapies, including photodynamic therapy, chemodynamic therapy, sonodynamic therapy, thermodynamic therapy, radiodynamic therapy, and electrodynamic therapy. The challenges and prospects for clinical applications of MSNs-based ROS-activated cancer treatments are also discussed.

COORDINATION CHEMISTRY REVIEWS (2022)

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Review Nanoscience & Nanotechnology

Recent advances in development of dendriticpolymer-basednanomedicines for cancer diagnosis

Haonan Li et al.

Summary: Dendritic polymers with highly branched three-dimensional architectures and low viscosity have great potential in various biomedical applications. Despite most review articles focusing on drug or gene delivery, there is still a lack of discussion on their function as cancer diagnosis agents.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Lightweight, Superelastic, and Hydrophobic Polyimide Nanofiber /MXene Composite Aerogel for Wearable Piezoresistive Sensor and Oil/Water Separation Applications

Hu Liu et al.

Summary: The article describes a conductive polyimide nanofiber/MXene composite aerogel with features such as ultralow density, temperature tolerance, superior compressibility, and fatigue resistance, suitable for applications in piezoresistive sensors and oil/water separation.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Targeted Enrichment of Enzyme-Instructed Assemblies in Cancer Cell Lysosomes Turns Immunologically Cold Tumors Hot

Shenglu Ji et al.

Summary: This study introduces a novel LMP inducer named TPE-Py-pYK(TPP)pY, which can effectively convert immunologically cold tumors to hot by inducing ICD, providing a new strategy for cancer immunotherapy.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Multidisciplinary Sciences

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

Lizhi Liu et al.

Summary: Cell membrane coated nanoparticles have unique properties that make them attractive for nanomedical applications, but it has been found that most nanoparticles are only partially coated. This partial coating can impact the biological fate of the nanoparticles.

NATURE COMMUNICATIONS (2021)

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Review Nanoscience & Nanotechnology

Targeted drug delivery strategies for precision medicines

Mandana T. Manzari et al.

Summary: Precision medicine offers personalized treatment strategies for individual patients, especially in the field of cancer therapy. While there have been some clinical successes, challenges such as drug toxicities and resistance still hinder the full potential of precision medicine. Advanced drug delivery materials and approaches provide opportunities to improve therapeutic outcomes and overcome pharmacological issues in cancer treatment.

NATURE REVIEWS MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Transformable Nanosensitizer with Tumor Microenvironment-Activated Sonodynamic Process and Calcium Release for Enhanced Cancer Immunotherapy

Xuan Tan et al.

Summary: The study introduces a smart nanosonosensitizer TiO2@CaP which enhances the generation of reactive oxygen species (ROS) under ultrasound activation, inducing mitochondrial dysfunction in the tumor microenvironment and promoting immunogenic cell death, resulting in T-cell infiltration and systemic antitumor immunity. This approach holds promise for developing TME-activatable sonosensitizers with temporospatial control over antitumor responses.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Chemistry, Multidisciplinary

Second Near-Infrared Light-Activatable Polymeric Nanoantagonist for Photothermal Immunometabolic Cancer Therapy

Cheng Xu et al.

Summary: Immunometabolic modulation through a second near-infrared (NIR-II) photothermally activatable semiconducting polymeric nanoantagonist (ASPA) provides a new approach for synergistic photothermal immunometabolic therapy of cancer. This remotely controlled immunometabolic regulation enhances cytotoxic T cell functions, suppresses regulatory T cell activities, and leads to efficient primary tumor inhibition, pulmonary metastasis prevention, and long-term immunological memory. This work offers a generic polymeric approach for precise spatiotemporal regulation of cancer immunometabolism.

ADVANCED MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Charge-Reversal Polymer Nano-modulators for Photodynamic Immunotherapy of Cancer

Shasha He et al.

Summary: The study presents a charge-reversal polymer nano-modulator activated by tumor micro-environment for photodynamic immunotherapy of cancer. This nano-modulator regulates the balance between CTLs and Tregs, promotes dendritic cell maturation, and effectively inhibits both primary and distant tumors.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Review Immunology