Journal
CHEMCATCHEM
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cctc.202300989
Keywords
Carbon Acids; Photochemistry; Catalysis; C-H Activation; Radical Chemistry
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The utilization of photo-induced processes in C-H functionalization via radical pathways has shown great potential for the preparation and modification of complex organic compounds. While current methods mainly focus on nucleophilic radicals derived from hydridic C-H bonds, the activation and potential applications of electrophilic radicals from protic C-H bonds remain largely unexplored. This review aims to highlight the important discoveries and showcase examples of protic C(sp(3))-H bond activation through mechanistically diverse modes unified by proton-coupled electron transfer (PCET) concepts.
The utilization of photo-induced processes in C-H functionalization via radical pathways has emerged as a highly promising strategy for the preparation and modification of complex organic compounds. While current methods for generating carbon-centred radicals from C-H bonds primarily focus on hydridic C-H bonds to yield nucleophilic radical species, the reactivity and potential applications of electrophilic radicals derived from protic C-H bonds remain largely unexplored. In this review, we aim to shed light on the seminal findings regarding the activation of protic C(sp(3))-H bonds while also showcasing noteworthy examples of this radical formation process. Mechanistically diverse modes of activation are discussed, unified by proton-coupled electron transfer (PCET) concepts.
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