4.7 Article

Hyperosmotic polydixylitol for crossing the blood brain barrier and efficient nucleic acid delivery

Journal

CHEMICAL COMMUNICATIONS
Volume 51, Issue 17, Pages 3645-3648

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc09871d

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Funding

  1. Technology Development Program for Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET), Republic of Korea [312031-3]
  2. National Research Foundation of Korea (NRF) - Korea government (MEST) [2011-0028922]

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Here, we introduce a polydixylitol based highly osmotic polymer that not only transmigrates the BBB by intra-arterial infusion of osmotic polyol but also triggers cellular uptake via modulation of caveolae mediated endocytosis.

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