Palladates of the [NHC⋅H][Pd(NH2)(CC)Cl2] Type as Effective Pre-catalysts for the Formation of C-C and C-N Bonds

The environmentally friendly, simple synthesis of a family complexes of the general formula [NHC & sdot;H][Pd(NH2)(CC)Cl-2] (CC=biphenyl) is presented. The catalytic activity of these air- and moisture-stable complexes was evaluated as a function of the imidazolium counterion. These pre-catalysts can be converted, under catalytic conditions, to Pd-NHC species enabling the Suzuki-Miyaura, Sonogashira, and Buchwald-Hartwig amination reactions under very mild operating conditions.

Automated summary

This article presents an environmentally friendly and simple synthesis method for stable complexes. By evaluating the catalytic activity of imidazolium salts as counterions, the complexes can be converted to Pd-NHC species, enabling various amination reactions under mild conditions.