4.6 Article

DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Single-cell delineation of lineage and genetic identity in the mouse brain

Rachel C. Bandler et al.

Summary: In this study, clonal relationships and transcriptomic signatures during mouse forebrain development were tracked using massively parallel tagging of progenitors, revealing diverse types of GABAergic neurons sharing a common lineage. Divergence of GABAergic clones was found to occur during embryogenesis upon cell-cycle exit, suggesting that differentiation into subtypes is initiated as a lineage-dependent process at the progenitor cell level.

NATURE (2022)

Article Biochemistry & Molecular Biology

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2022 update

Alexander E. Ostrovsky et al.

Summary: Galaxy is a mature and browser accessible workbench for scientific computing, allowing scientists to easily share, analyze, and visualize their data. It has a strong global community and support from national infrastructure providers. Key technical developments of Galaxy include improved user interface, interactive tools for data analysis, and a complete suite of machine learning tools. Important scientific developments enabled by Galaxy include Vertebrate Genome Project (VGP) assembly workflows and global SARS-CoV-2 collaborations.

NUCLEIC ACIDS RESEARCH (2022)

Article Multidisciplinary Sciences

MTG8 interacts with LHX6 to specify cortical interneuron subtype identity

Zeinab Asgarian et al.

Summary: This study identifies MTG8 as a co-factor of LHX6, which plays a crucial role in the development of cortical interneurons. The findings suggest that early specification programs, mediated by transcriptional co-factors, are important for the emergence of cortical interneuron heterogeneity from the embryonic telencephalic germinal zones.

NATURE COMMUNICATIONS (2022)

Review Biochemistry & Molecular Biology

Altered GABA-mediated information processing and cognitive dysfunctions in depression and other brain disorders

Thomas Prevot et al.

Summary: Cognitive dysfunctions are a common occurrence in depression, other psychiatric disorders, and aging, potentially linked to altered GABA activity, specifically involving a decrease in the function of SST+ GABA neurons, leading to cognitive impairments.

MOLECULAR PSYCHIATRY (2021)

Review Neurosciences

Parvalbumin interneuron vulnerability and brain disorders

Jacob B. Ruden et al.

Summary: PV-INs, as parvalbumin-expressing interneurons, are highly vulnerable to stressors and implicated in various neuro-psychiatric diseases. Factors contributing to their vulnerability include substantial energy requirements, strong excitatory drive, and a unique developmental trajectory. Understanding and addressing these stressors is essential for developing therapies to protect PV-INs and maintain critical brain functions.

NEUROPSYCHOPHARMACOLOGY (2021)

Article Cell Biology

PlexinA4-Semaphorin3A-mediated crosstalk between main cortical interneuron classes is required for superficial interneuron lamination

Greta Limoni et al.

Summary: Deep-layer inhibitory interneurons (INs) in the mammalian cerebral cortex control the laminar allocation of 5-HT receptor 3a-expressing (HTR3A(+)) cortical INs (hlNs) by secreting Semaphorin3A (SEMA3A).

CELL REPORTS (2021)

Article Neurosciences

Long-term behavioral and cell-type-specific molecular effects of early life stress are mediated by H3K79me2 dynamics in medium spiny neurons

Hope Kronman et al.

Summary: Early life stress increases susceptibility to chronic stress in adulthood, with alterations in histone modifications in the nucleus accumbens (NAc) being crucial for these effects. Specifically, dimethylation of lysine 79 of histone H3 (H3K79me2) and the enzymes controlling this modification play a key role in the expression of stress susceptibility induced by early life stress. Systemic delivery of a small molecule inhibitor of DOT1L can reverse the behavioral deficits induced by early life stress, highlighting the clinical relevance of this epigenetic mechanism.

NATURE NEUROSCIENCE (2021)

Article Neurosciences

Islet1 Precursors Contribute to Mature Interneuron Subtypes in Mouse Neocortex

Faez Siddiqi et al.

Summary: Cortical interneurons are primarily derived from the medial and caudal ganglionic eminences during embryogenesis, with some contribution from the preoptic area, but a small population also originates from the lateral ganglionic eminence. Different populations of cells from various origins show both common and distinct lineage contributions towards the fate of cortical interneurons.

CEREBRAL CORTEX (2021)

Article Multidisciplinary Sciences

FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

Goichi Miyoshi et al.

Summary: This study reveals that FoxG1 regulates the formation of cortical GABAergic circuits affecting social behavior during a specific postnatal time window in mouse models of ASD. The second postnatal week is a critical period to prevent ASD-like social impairments. Transplantation of GABAergic precursor cells or modulation of GABAergic tone can respectively ameliorate or exacerbate circuit functionality and social behavioral defects.

NATURE COMMUNICATIONS (2021)

Article Cell & Tissue Engineering

Hippocampal CA1 Somatostatin Interneurons Originate in the Embryonic MGE/POA

Zeinab Asgarian et al.

STEM CELL REPORTS (2019)

Article Neurosciences

Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo

Patrick Piero Bovio et al.

MOLECULAR NEUROBIOLOGY (2019)

Article Biochemistry & Molecular Biology

DOT1L promotes progenitor proliferation and primes neuronal layer identity in the developing cerebral cortex

Henriette Franz et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Early emergence of cortical interneuron diversity in the mouse embryo

Da Mi et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

Developmental diversification of cortical inhibitory interneurons

Christian Mayer et al.

NATURE (2018)

Article Multidisciplinary Sciences

Single-cell RNA sequencing identifies distinct mouse medial ganglionic eminence cell types

Ying-Jiun J. Chen et al.

SCIENTIFIC REPORTS (2017)

Review Neurosciences

Interplay of environmental signals and progenitor diversity on fate specification of cortical GABAergic neurons

Juliana A. Brandao et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Article Cell Biology

Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate

Timothy J. Petros et al.

CELL REPORTS (2015)

Review Biochemistry & Molecular Biology

Mechanisms regulating GABAergic neuron development

Kaia Achim et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2014)

Article Biotechnology & Applied Microbiology

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love et al.

GENOME BIOLOGY (2014)

Article Developmental Biology

Epigenetic regulation of neural stem cell fate during corticogenesis

Chai MuhChyi et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2013)

Article Neurosciences

Lineage-specific laminar organization of cortical GABAergic interneurons

Gabriele Ciceri et al.

NATURE NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Neurons on the Move: Migration and Lamination of Cortical Interneurons

Clare Faux et al.

NEUROSIGNALS (2012)

Article Neurosciences

Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness

Juan Antonio Sanchez-Alcaniz et al.

NEURON (2011)

Article Multidisciplinary Sciences

Inhibitory interneurons in a cortical column form hot zones of inhibition in layers 2 and 5A

Hanno S. Meyer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Cell Biology

Epigenetic regulation in neural stem cell differentiation

Berry Juliandi et al.

DEVELOPMENT GROWTH & DIFFERENTIATION (2010)

Article Multidisciplinary Sciences

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex

Nicole Buettner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Neurosciences

The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons

Diego M. Gelman et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Developmental Biology

A spatial bias for the origins of intemeuron subgroups within the medial ganglionic eminence

Carl P. Wonders et al.

DEVELOPMENTAL BIOLOGY (2008)

Article Neurosciences

Fate mapping nkx2.1-lineage cells in the mouse telencephalon

Qing Xu et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2008)

Article Neurosciences

Chemokine signaling controls intracortical migration and final distribution of GABAergic Interneurons

Guillermina Lopez-Bendito et al.

JOURNAL OF NEUROSCIENCE (2008)

Review Neurosciences

The origin and specification of cortical interneurons

Carl P. Wonders et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Review Neurosciences

A long, remarkable journey:: Tangential migration in the telencephalon

O Marín et al.

NATURE REVIEWS NEUROSCIENCE (2001)